High-Resolution Characterization of Protein-Conjugated, mRNA-Loaded Lipid Nanoparticles by Analytical Ultracentrifugation [0.03%]
分析性超速离心技术表征与蛋白质结合的、装载有信使RNA的脂质纳米颗粒
Sophia Bird,Connor Smith,Nahal Habibi et al.
Sophia Bird et al.
The study describes a novel use for the Custom Grid (CG) algorithm in UltraScan targeting lipid nanoparticles (LNPs) with cargos ranging from empty LNPs, LNPs loaded with messenger RNA (mRNA), and LNPs conjugated with proteins, or both. The...
Mom and Baby Wellness with a Smart Lactation Pad: A Wearable Sensor-Embedded Lactation Pad for on-Body Quantification of Glucose in Breast Milk [0.03%]
基于智能乳垫的母婴健康监护：一种体内量化母乳中葡萄糖浓度的可穿戴传感器乳垫
Abdulrahman Al-Shami,Haozheng Ma,Melissa Banks et al.
Abdulrahman Al-Shami et al.
Wearable sensors are transforming healthcare by facilitating rapid, non-invasive, on-body biochemical analysis in biofluids such as sweat, tears, saliva, and blood, providing real-time insights into health conditions. Despite extensive acad...
Patterning Bacterial Cells on Quasi-Liquid Surfaces for Biofilm Morphological Control [0.03%]
在准液态表面图案化细菌以控制菌膜形态
Fangying Chen,Dylan Boylan,Fabiha Zaheen Khan et al.
Fangying Chen et al.
Bacterial cells within biofilms exhibit resistance to antibiotics, presenting persistent health risks. Current approaches to inhibit biofilm formation have limitations due to their poor biofilm morphological control. For instance, bacterici...
Crossbow Bioreactors for Studying the Effects of Time-Varying Mechanical Preload and Afterload on Engineered Cardiac Tissues [0.03%]
用于研究机械性预载和后载随时间变化对工程心脏组织的影响的交叉弓生物反应器
Abbigail Helfer,Nicholas Strash,Marisa Patsy et al.
Abbigail Helfer et al.
Mechanical loading plays a critical role in heart development and function, with cardiac preload (tissue stretch during chamber filling) and afterload (resistance against which the heart works to eject blood) potentially playing distinct ro...
Delivery of Angiogenic Therapy from Flowable Hyaluronic Acid Porous Scaffolds Results in Functional Improvement without Anti-Inflammatory Agents [0.03%]
无需抗炎剂的血管生成疗法的递送使功能得到改善
Kevin Erning,Katrina L Wilson,Cara S Smith et al.
Kevin Erning et al.
Ischemic stroke, a blockage in the vasculature of the brain that results in insufficient blood flow, is one of the world's leading causes of disability. The cascade of inflammation and cell death that occurs immediately following stroke dri...
Cold Quad-Modal Nanocomplex for Precise and Quantitative In Vivo Stem Cell Tracking [0.03%]
用于精确和定量体内干细胞追踪的冷四模态纳米复合物
Ali Shakeri-Zadeh,Chao Wang,Shreyas Kuddannaya et al.
Ali Shakeri-Zadeh et al.
Current single imaging modalities typically lack the ability to simultaneously offer detailed anatomical visualization and quantitative cellular information, which is crucial for evaluating and improving therapeutic efficacy. This work deve...
Multifunctional Nanovaccine Sensitizes Breast Cancer to Immune Checkpoint Therapy [0.03%]
多功能纳米疫苗使乳腺癌对免疫检查点疗法敏感
Carina Peres,Ana I Matos,Bárbara Carreira et al.
Carina Peres et al.
Breast cancer is the primary cause of cancer-related death in women worldwide. Breast cancer subtypes are characterized by different gene expression patterns, which drive their prognostic factors and therapeutic options. Among them, triple-...
The Synergy of Artificial Intelligence and 3D Bioprinting: Unlocking New Frontiers in Precision and Tissue Fabrication [0.03%]
人工智能与3D生物打印的协同作用：精准制造和组织构建的新前沿
Joao Vitor Silva Robazzi,I Deniz Derman,Deepak Gupta et al.
Joao Vitor Silva Robazzi et al.
This Review examines the transformative role of artificial intelligence (AI) in 3D bioprinting, focusing on how advanced AI technologies enhance its precision, functionality, and scalability. AI, through branches, such as machine learning (...
Wenting Shi,Ying Xi,Xinyi Sheng et al.
Wenting Shi et al.
Injectable hydrogels represent a promising strategy for the extended release of biological molecules, thereby reducing the frequency of injections. This study introduces a novel system based on Michael addition of dextran and polyethylene g...
High-Throughput Microfluidic-Mediated Assembly of Layer-by-Layer Nanoparticles [0.03%]
一种高通量的基于微流体技术逐层组装纳米粒子的方法
Ivan S Pires,Ezra Gordon,Heikyung Suh et al.
Ivan S Pires et al.
Surface modification of nanoparticles (NPs) via the layer-by-layer (LbL) technique is a promising approach to generate targeted drug delivery vehicles. LbL-NPs have been successfully used in preclinical models for controlled drug release, t...