Benchtop Fabrication and Integration of Laser-Induced Graphene Strain Gauges and Stimulation Electrodes in Muscle on a Chip Devices [0.03%]
基于激光诱导石墨烯的应变传感器和刺激电极在芯片肌肉器件中的台式制造与集成
Anastasia Svetlova,Hiu Tung J Law,Dawon Kim et al.
Anastasia Svetlova et al.
Muscle on a Chip devices are valuable research tools for interrogating the structure and physiology of engineered heart, skeletal, and smooth muscle tissue constructs from the molecular to the multi-cellular level. However, many existing de...
Controlling 3D Contractility via Engineered Fibrous Hydrogel Composites [0.03%]
基于工程纤维水凝胶复合材料的三维可控收缩研究
Karen L Xu,Yuqi Zhang,Alysse DeFoe et al.
Karen L Xu et al.
Complex and dynamic mechanobiological crosstalk occurs between cells and their extracellular matrix (ECM) to support contraction, a process required for tissue morphogenesis and wound healing. In vitro models can be used to study this cross...
Jiazhu Xu,Joel Aboagye,Marcella Edwards et al.
Jiazhu Xu et al.
The phenotypic immaturity of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) remains a critical barrier to their effective use in disease models, drug screening, and cardiac regeneration. Current culture platforms sti...
A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration [0.03%]
一种血管化的微生理系统可在体外再现 Wolff's 法则从而用于研究 ewing 肉瘤的增殖和迁移行为
Maria Vittoria Colombo,Chiara Arrigoni,Tobias Faehling et al.
Maria Vittoria Colombo et al.
Endochondral ossification (ECO) is the process at the basis of long bone development, occurring in children and involving vascularization and subsequent mineralization of a cartilage template. Deregulated bone developmental pathways could c...
Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal-Organic Frameworks [0.03%]
基于金属有机框架材料的mRNA包封及基因传递递送策略研究
Harrison Douglas Lawson,Huy Hoang Nguyen,Keng-Jung Lee et al.
Harrison Douglas Lawson et al.
Metal-organic frameworks (MOFs) have evolved from uses in catalysis and gas storage to exciting applications in biomedicine, particularly in drug delivery. Initially, MOFs are primarily used to deliver small molecules, recent innovations ha...
Resonance Energy Transfer-Driven Photothermal Nanoagent Enables Melanoma Ablation Under Low-Power Near-Infrared Irradiation [0.03%]
基于共振能量转移的光热治疗剂用于低功率近红外照射下的黑色素瘤消融
Prem Singh,Constanze Raitmayr,Syed Zaki Husain Rizvi et al.
Prem Singh et al.
Photothermal therapy (PTT) utilizes near-infrared (NIR) light to activate photothermal agents, enabling localized tumor ablation. However, conventional agents require high laser power densities to reach therapeutic temperatures, exceeding t...
DNA Helix Bundle-Encoded Multi-Bit Information Readout by Sapphire-Supported Nanopores [0.03%]
蓝宝石支撑纳米孔读取DNA螺旋束编码的多比特信息
Pengkun Xia,Deeksha Satyabola,Nimarpreet Kaur Bamrah et al.
Pengkun Xia et al.
The increasing demand for high-capacity data storage continues to drive innovation in memory technologies. DNA has emerged as a promising high-density data storage medium. Data storage using DNA nanostructures is compatible with complex dat...
Structurally Engineered Ferrous Metal-Organic Framework as a Chemodynamic Therapy Nanoagent for Concurrent Hydroxyl Radical and Singlet Oxygen Generation [0.03%]
结构工程铁基金属有机骨架协同生成羟基和单线态氧的化学动力学治疗纳米药物
Chao Wang,Kongbrailatpam Shitaljit Sharma,Yoon Tae Goo et al.
Chao Wang et al.
Chemodynamic therapy (CDT) is an emerging cancer treatment that employs transition metal-based nanoagents to catalyze the conversion of elevated intracellular hydrogen peroxide in malignant cells into cytotoxic hydroxyl radicals (•OH) via ...
RNA-Micelles as Self-Assembling Structures for Efficient Co-Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis [0.03%]
用于协同递送治疗结直肠癌肺转移的siRNA和核苷类似物的自组装RNA胶束
Kai Jin,Piotr Rychahou,Daniel W Binzel et al.
Kai Jin et al.
SiRNA has been widely studied in cancer gene silencing over the last 25 years. However, few siRNA-based therapeutics have been approved by the FDA. An RNA-micelle platform provides a powerful therapeutic tool through simple one-step, high-y...
Controlling Payload Heterogeneity in Lipid Nanoparticles for RNA-Based Therapeutics [0.03%]
控制基于RNA的治疗中脂质纳米颗粒载药异质性
Turash Haque Pial,Sixuan Li,Jinghan Lin et al.
Turash Haque Pial et al.
Lipid nanoparticles (LNPs) are a leading platform for nucleic acid delivery, yet conventional assembly by mixing lipids with RNA yields particles with heterogeneous, bimodal payload distribution. Our transfection experiments demonstrate tha...