Engineering pendant group chemistry to control hydrophilicity and oxidative degradation of thioketal-based biomaterials [0.03%]
利用 Pendant Group 化学工程来控制硫酮基生物材料的亲水性和氧化降解性
Karina A Bruce,Dylan W Marques,Alan J Fullenkamp et al.
Karina A Bruce et al.
Reactive oxygen species (ROS)-responsive biomaterials have drawn increasing interest in regenerative medicine, drug delivery systems, and biodegradable implants. These materials are especially promising as local ROS levels are increased in ...
Self-Assembled Nanoclay Gel with Spheroid MSC-Derived Exosome Mimetics to Integrate Demineralized Bone Matrix and Noggin-Targeting miRNA for Synergistic Osteogenesis [0.03%]
一种自组装纳米粘土凝胶，含有类干细胞衍生的外泌体模制品，将脱矿骨基质与针对Noggin的miRNA相结合，用于协同成骨作用
Changlu Xu,Zhi Li,Minjee Kang et al.
Changlu Xu et al.
Demineralized bone matrix (DBM) is widely used as an alternative to autografts for repairing bone defects, but its clinical efficacy is limited by poor retention at the defect site and inadequate osteogenic capacity. Here, we developed a mu...
A Flexible and Regenerative Aptameric Graphene-Nafion Biosensor for Cytokine Storm Biomarker Monitoring in Undiluted Biofluids toward Wearable Applications [0.03%]
一种灵活可再生的适配体石墨烯-纳滤膜生物传感器用于未稀释生物液体细胞因子风暴生物标志物监测以实现可穿戴应用
Ziran Wang,Zhuang Hao,Xuejun Wang et al.
Ziran Wang et al.
Wearable sensors that can conveniently detect cytokine levels in human biofluids are essential for assisting hospitals to maximize the benefits of anti-inflammatory therapies and avoid cytokine storm with high mortality. Measurement of cyto...
Shear-Induced CROSS (Cellular RedOx Spreading Shield) Assembly Sustains Neurotrophic Extracellular Vesicle Production for Functional Neural Networks [0.03%]
剪切诱导的CROSS（细胞类红氧屏蔽）组装可维持神经营养外泌体的产生以支持功能神经网络
Ryan C Miller,Sehong Kang,Jason Wang et al.
Ryan C Miller et al.
Stem cell-derived neuron-glia models provide a robust platform for studying brain physiology, developing therapeutics, and exploring biocomputation. Extracellular vesicles (EVs) containing neurotrophic factors, also derived from stem cells,...
Buckling-Resistant and Trace-Stacked (BRATS) Design Enables Aid-Free Implantation of Flexible Multielectrode Array with Minimized Inflammatory Tissue Response [0.03%]
一种抗屈曲和可轨迹堆叠(BRATS)设计，可在最小化炎症组织反应的情况下实现植入式柔性多电极阵列的无需辅助自由植入
May Yoon Pwint,Delin Shi,X Tracy Cui
May Yoon Pwint
Intracortical microelectrode arrays (MEAs) are vital tools for brain-machine interface applications and basic neuroscience research, with the potential to advance treatments for neurological disorders and enhance the understanding of the ne...
Rationally designed anisotropic and auxetic hydrogel patches for adaptation to dynamic organs [0.03%]
用于适应动态器官的理性设计各向异性和负泊松比水凝胶补丁
Parth Chansoria,John Blackwell,Emma L Etter et al.
Parth Chansoria et al.
Current hydrogel or fabric patches for organ repair are generally not designed to conform to the complex mechanics of dynamic organs such as the lung or heart. This work presents a new, biocompatible and bilayered, hydrogel-based patch plat...
Benchtop Fabrication and Integration of Laser-Induced Graphene Strain Gauges and Stimulation Electrodes in Muscle on a Chip Devices [0.03%]
基于激光诱导石墨烯的应变传感器和刺激电极在芯片肌肉器件中的台式制造与集成
Anastasia Svetlova,Hiu Tung J Law,Dawon Kim et al.
Anastasia Svetlova et al.
Muscle on a Chip devices are valuable research tools for interrogating the structure and physiology of engineered heart, skeletal, and smooth muscle tissue constructs from the molecular to the multi-cellular level. However, many existing de...
Controlling 3D Contractility via Engineered Fibrous Hydrogel Composites [0.03%]
基于工程纤维水凝胶复合材料的三维可控收缩研究
Karen L Xu,Yuqi Zhang,Alysse DeFoe et al.
Karen L Xu et al.
Complex and dynamic mechanobiological crosstalk occurs between cells and their extracellular matrix (ECM) to support contraction, a process required for tissue morphogenesis and wound healing. In vitro models can be used to study this cross...
Jiazhu Xu,Joel Aboagye,Marcella Edwards et al.
Jiazhu Xu et al.
The phenotypic immaturity of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) remains a critical barrier to their effective use in disease models, drug screening, and cardiac regeneration. Current culture platforms sti...
A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration [0.03%]
一种血管化的微生理系统可在体外再现 Wolff's 法则从而用于研究 ewing 肉瘤的增殖和迁移行为
Maria Vittoria Colombo,Chiara Arrigoni,Tobias Faehling et al.
Maria Vittoria Colombo et al.
Endochondral ossification (ECO) is the process at the basis of long bone development, occurring in children and involving vascularization and subsequent mineralization of a cartilage template. Deregulated bone developmental pathways could c...