Temporal Proteomic Profiling Reveals Tissue-Specific and Coordinated Metabolic Reprogramming in Skeletal Muscle and Liver during Prolonged Fasting [0.03%]
时间蛋白质组学谱分析揭示了长期禁食期间骨骼肌和肝脏中的组织特异性和协调的代谢重编程现象
Leilei Cui,Lin Zeng,Mengqi Yang et al.
Leilei Cui et al.
Fasting triggers profound systemic metabolic adaptations that are essential for survival during nutrient scarcity, yet the temporal dynamics and cross-tissue coordination of proteomic remodeling remain incompletely characterized. Here, we e...
Assessing Extracellular Vesicle Proteins as Predictive Biomarkers for Developing Type 1 Diabetes [0.03%]
评估细胞外囊泡蛋白作为1型糖尿病预测生物标志物的能力
Panshak P Dakup,Lisa M Bramer,Athena Schepmoes et al.
Panshak P Dakup et al.
Plasma extracellular vesicles (EVs) are considered excellent sources for biomarker discovery since they carry signatures of their cellular origin and disease processes. In this paper, we evaluate the potential of plasma EV proteomics analys...
Proteomic Profiling Using a Proximity Extension Assay Panel on Serum Samples Stored at -25°C Over Several Decades [0.03%]
长期存放在-25°C的血清样本的邻近扩展测定法蛋白组谱分析
Steffan Daniel Bos,Sigrún Helga Lund,Renée Turzanski Fortner et al.
Steffan Daniel Bos et al.
The advent of proteomics assays that provide accurate levels of thousands of proteins from relatively small sample volumes opens possibilities for biomarker research in biobanks with valuable samples. In this study, we leverage the applicab...
Peptidomic Profiling Reveals Extracellular Matrix Remodeling Signatures Discriminative of Multiple Myeloma [0.03%]
肽组学谱型揭示了多重骨髓瘤的细胞外基质重塑特征
Maria Frantzi,Melika Ahangar,Antonia Vlahou et al.
Maria Frantzi et al.
Multiple myeloma (MM) evolves from monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) with annual progression rates of 1% and 10%, respectively. Current risk models don't fully capture the underl...
A Single-Cell Proteomic Atlas of Cardiac Fibrosis Reveals Cell-Type-Specific Remodeling and Discordant Protein Regulation [0.03%]
单细胞蛋白质组学揭示了心脏纤维化中特定于不同细胞类型的重塑和失调的蛋白质调节
Jiajia Hu,Chengliang Zhang,Ziyi Li et al.
Jiajia Hu et al.
Cardiac fibrosis is a hallmark of progressive cardiac remodeling and heart failure, characterized by excessive extracellular matrix (ECM) deposition and complex cellular interactions. While bulk proteomic studies have provided insights into...
Enabling Variant Proteogenomic Assay Development Through a Peptide Target Selection Pipeline and Web Application [0.03%]
通过肽段靶标选择管道和网络应用实现变异蛋白基因组检测开发
Constantinos Blidjios,Pallab Bhowmick,Vincent R Richard et al.
Constantinos Blidjios et al.
The quantification of key protein variants can guide precision oncology to enable better identification of driver mutations. Bottom-up assays infer parent protein levels through the quantification of surrogate peptides. Assay methods design...
iMPI: An Integrative Database for MicroProteins Encoded by Intron Retention in Tumors [0.03%]
iMPI：肿瘤中由内含子保留编码的微蛋白综合数据库
Jiamin Hu,Yongqiang Zheng,Xin Huang et al.
Jiamin Hu et al.
Research advancements made in the last decade have shed light on the dysregulation of cellular mechanisms that lead to aberrant and pathologic intron retention (IR). IR is not merely a mechanism of gene regulation but may also play a potent...
Integrated Transcriptomic, Proteomic, and Pharmacologic Profiling of 2D and 3D Patient-Derived GCTB Cell Lines Reveals Culture-Dependent Drug Response Determinants [0.03%]
整合转录组、蛋白质组和药理学谱型的二维和三维患者衍生性GCTB细胞系的药物反应决定因素研究
Yomogi Shiota,Ikumi Fujita,Sakura Hayashi et al.
Yomogi Shiota et al.
Giant cell tumor of bone (GCTB) is an intermediate bone neoplasm defined by recurrent H3F3A mutations and limited systemic treatment options beyond denosumab. Patient-derived cancer cell lines (PDCs) offer a scalable platform for mechanisti...
Comprehensive DIA-MS Proteomics of Root Basal Nodes Elucidates Mechanisms of Salt Tolerance in Rice [0.03%]
基于水稻根基节的DIA质谱蛋白质组学解析盐胁迫 tolerance 的机制
Cheol Woo Min,Choonseok Lee,Ravi Gupta et al.
Cheol Woo Min et al.
Soil salinity severely affects rice growth, yield, and quality, posing a global food security challenge. Rice is particularly vulnerable to high salinity, which restricts growth and tolerance to other stresses. To address this, breeding eff...
Integrative Quantitative Proteomics and N-Glycoproteomics Reveal Age-Processing of N-Glycosylation in Caenorhabditis elegans [0.03%]
整合定量蛋白质组和N-糖蛋白组揭示Caenorhabditis elegans中N-聚糖成熟处理的年龄相关变化
Xiaoyu Hu,Weirong Xiang,Suideng Qin et al.
Xiaoyu Hu et al.
N-glycosylation, a highly diverse post-translational modification, critically regulates organismal aging. The Caenorhabditis elegans (C. elegans) model is one of the excellent aging models, which exhibits distinctive N-glycosylation feature...