A Deep Learning Model for Prediction of Unknown Gene Functionality: Gene Bio-BERT [0.03%]
一种预测未知基因功能的深度学习模型：Gene Bio-BERT
Srinivas Kudipudi,Vyshnavi Durga Chirumamilla,Pavani Ippili
Srinivas Kudipudi
The Human Genome Project (HGP) was a large international research effort that timelined between 1990 and 2003, marking the successful mapping of the entire human genome. Despite the promising performance of deep learning models, especially ...
Comparative Evaluation of Adaptive Focused Acoustics- and SP3-Based Workflows for Deep Proteomic Profiling of 30-Year-Old Formalin-Fixed Paraffin-Embedded Tissues [0.03%]
基于自适应聚焦声学和SP3的深度蛋白质组学分析三十年前石蜡包埋组织的比较评估
Rei Noguchi,Masatsugu Ishii,Yuki Adachi et al.
Rei Noguchi et al.
Formalin-fixed paraffin-embedded (FFPE) tissues represent a vast archive for translational research that offers access to specimens with clinical outcomes. However, formalin-induced crosslinking hinders efficient protein extraction and limi...
MODY Mutations in Transcription Factors HNF1A and HNF1B Affect the Production of Interferon Signaling Proteins: Evidence at the Proteome Level [0.03%]
转录因子HNF1A和HNF1B的MODY突变影响I型干扰素信号蛋白产生：蛋白质组学证据
Ksenia G Kuznetsova,Jakub Vašíček,Dafni Skiadopoulou et al.
Ksenia G Kuznetsova et al.
This discovery study investigated the impact of MODY-associated mutations in hepatocyte nuclear factors HNF1A and HNF1B on the cellular proteome, aiming to identify affected pathways and advance understanding of diabetes pathogenesis. Human...
Comparative Phosphoproteomic Analysis Demonstrates That AMPKα2 Knockout Exacerbates Hepatic Aging in Mice [0.03%]
AMPKα2敲除通过比较磷酸化蛋白质组学促进小鼠肝脏衰老
Han Qiao,Congmin Tang,Wenzhuo Yu et al.
Han Qiao et al.
Aging accompanies metabolic dysregulation, wherein the liver exhibits high sensitivity to age-related changes. AMP-activated protein kinase α2 (AMPKα2), a key energy metabolism regulator, lacks investigation regarding germline knockout ef...
Organ-Derived Spectral Libraries Improve Sensitivity in DIA Plasma Peptidomics [0.03%]
基于组织的光谱图库可提高DIA技术在血浆肽组学中的灵敏度
Yusei Okuda,Ryo Konno,Tomomi Taguchi et al.
Yusei Okuda et al.
Plasma contains diverse bioactive peptides that play crucial roles in maintaining homeostasis and regulating disease responses. However, the presence of peptides derived from high-abundance proteins such as albumin makes comprehensive analy...
Proteomic Insights Into Moxifloxacin Efficacy and Resistance in Vibrio parahaemolyticus [0.03%]
莫西沙星对副溶血性弧菌有效性及耐药性的蛋白质组学研究见解
Zhen Li,Xin Chen,Chunyan Jia et al.
Zhen Li et al.
The emergence of multidrug-resistant Vibrio parahaemolyticus poses major public health challenges, necessitating new treatment strategies. This research uses quantitative proteomics to explore the underlying antibiotic stress response mecha...
Exoproteome Remodeling by the BraI/R Quorum Sensing Circuit and Interspecies Competition in Paraburkholderia [0.03%]
淬灭回路和种间竞争对Burkholderia胞外蛋白的影响
Gabrielle Tomé Cordeiro,Yara Martins da Silva,Giovanna Fernandes Lessa et al.
Gabrielle Tomé Cordeiro et al.
Quorum sensing (QS) is a cell-to-cell communication mechanism that enables bacteria to coordinate collective behaviors in response to population density. The BraI/R QS system is conserved among Burkholderia and Paraburkholderia species, and...
Gabriella Salazar,Anna Battenhouse,Andrew J Kim et al.
Gabriella Salazar et al.
Protein-protein interactions are central to the dynamic regulation of signaling pathways and provide critical insight into the cellular mechanisms underlying human disease. Our previous study demonstrated biochemical and genetic interaction...
Lipi Das,Kelly N Eckartt,Alexa Price-Whelan et al.
Lipi Das et al.
Pseudomonas aeruginosa is highly adaptable to environmental cues, including light. While specific light-responsive mechanisms have been studied in P. aeruginosa, the effects of light on biofilm proteomes remain unclear. Here, we employed qu...
Decade-Resolved Proteomic Profiling of Gastric Cancer FFPE Archives: Evaluating Storage-Associated Shifts and Signal Stability Over 50 Years [0.03%]
基于胃癌FFPE档案的十年级蛋白质组分辨率分析：评估储存相关变化和50年信号稳定性
Julia Osaki,Yomogi Shiota,Norihiro Teramoto et al.
Julia Osaki et al.
Archival formalin-fixed, paraffin-embedded (FFPE) tissues are invaluable for retrospective clinical research, yet the impact of multi-decade storage on quantitative proteomic fidelity remains poorly understood. We conducted a systematic, de...