Property-Guided Synthesis of Aza-Tricyclic Indolines: Development of Gold Catalysis En Route [0.03%]
基于属性的氮杂三环并吲哚啉类化合物的合成及金催化研究中的发展路程
Patrick M Barbour,Wei Wang,Le Chang et al.
Patrick M Barbour et al.
Antibiotic resistance is a worldwide public health threat that needs to be addressed by improved antibiotic stewardship and continuing development of new chemical entities to treat resistant bacterial infections. Compounds that work alongsi...
Umpolung Synthesis of Diarylmethylamines via Palladium-Catalyzed Arylation of N-Benzyl Aldimines [0.03%]
钯催化N-苄基醛亚胺的芳基化反应——茋类化合物的反转合成法
Minyan Li,Baris Yucel,Jacqueline Jiménez et al.
Minyan Li et al.
An umpolung synthesis of diarylmethylamine derivatives is presented. This reaction entails a Pd catalyzed arylation of 1,3-diaryl-2-azaallyl anions, in situ generated from N-benzyl aldimines. A Pd(NIXANTPHOS)-based catalyst together with hi...
Synthesis of Functionalized Hydrazines: Facile Homogeneous (N-Heterocyclic Carbene)-Palladium(0)-Catalyzed Diboration and Silaboration of Azobenzenes [0.03%]
功能化胲的合成：偶氮苯的选择性双硼化和硅硼化的简便均相[N-杂环卡宾]钯(0)催化体系
Melvyn B Ansell,George E Kostakis,Holger Braunschweig et al.
Melvyn B Ansell et al.
The bis(N-heterocyclic carbene)(diphenylacetylene)palladium complex [Pd(ITMe)2(PhC≡CPh)] (ITMe=1,3,4,5-tetramethylimidazol-2-ylidene) acts as a highly active pre-catalyst in the diboration and silaboration of azobenzenes to synthesize a se...
Palladium-Catalyzed α-Arylation of Methyl Sulfonamides with Aryl Chlorides [0.03%]
钯催化甲磺酰胺与芳基氯的α-arylation反应
Bing Zheng,Minyan Li,Gui Gao et al.
Bing Zheng et al.
A Palladium-catalyzed α-arylation of sulfonamides with aryl chlorides is presented. A Buchwald type precatalyst formed with Kwong's indole-based ligand enabled this transformation to be compatible with a large variety of methyl sulfonamide...
Selective Enzymatic Transformation to Aldehydes in vivo by Fungal Carboxylate Reductase from Neurospora crassa [0.03%]
Neurospora crassa真菌羧酸还原酶在 vivo 选择性催化醇和酯向醛的生物转化
Daniel Schwendenwein,Giuseppe Fiume,Hansjörg Weber et al.
Daniel Schwendenwein et al.
The enzymatic reduction of carboxylic acids is in its infancy with only a handful of biocatalysts available to this end. We have increased the spectrum of carboxylate-reducing enzymes (CARs) with the sequence of a fungal CAR from Neurospora...
A Ruthenium Catalyst for Olefin Metathesis Featuring an Anti-Bredt N-Heterocyclic Carbene Ligand [0.03%]
一个含有反Bredt N-杂环卡宾配体的钌催化剂应用于烯烃复分解反应
David Martin,Vanessa M Marx,Robert H Grubbs et al.
David Martin et al.
A ruthenium complex bearing an "anti-Bredt" N-heterocyclic carbene was synthesized, characterized and evaluated as a catalyst for olefin metathesis. Good conversions were observed at room temperature for the formation of di- and tri-substit...
Simplified Preparation of Trialkylvinylsilanes via the Silyl-Heck Reaction Utilizing a Second Generation Catalyst [0.03%]
通过二代催化剂利用硅代 Heck 反应简化三烷氧基乙烯基硅烷的制备
Jesse R McAtee,Sarah B Krause,Donald A Watson
Jesse R McAtee
Recently we reported a second-generation ligand, bis(3,5-di-tert-butylphenyl)(tert-butyl)phosphine, for the preparation of allyl silanes using the silyl-Heck reaction. We now show that this new ligand also provides superior reactivity in th...
Rhodium(I)-Catalyzed Intermolecular Hydroacylation of α-Keto Amides and Isatins with Non-Chelating Aldehydes [0.03%]
非螯合醛的α-酮酰胺和异丁酸酯的铑(I)催化分子间羟基酰化反应
Kevin G M Kou,Lauren E Longobardi,Vy M Dong
Kevin G M Kou
The application of the bidentate, electron-rich bisphosphine ligand, 1,3-bis(dicyclohexyl)phosphine-propane (dcpp), in rhodium(I)-catalyzed intermolecular ketone hydroacylation is herein described. Isatins and α-keto amides are shown to un...
An Efficient Protocol for the Palladium-catalyzed Asymmetric Decarboxylative Allylic Alkylation Using Low Palladium Concentrations and a Palladium(II) Precatalyst [0.03%]
一种高效的钯催化非对映选择性脱羧烯丙基烷基化反应协议，使用低浓度的钯和钯(ii)预催化剂
Alexander N Marziale,Douglas C Duquette,Robert A Craig nd et al.
Alexander N Marziale et al.
Enantioselective catalytic allylic alkylation for the synthesis of 2-alkyl-2-allylcycloalkanones and 3,3-disubstituted pyrrolidinones, piperidinones and piperazinones has been previously reported by our laboratory. The efficient constructio...
Exploiting Enzymatic Dynamic Reductive Kinetic Resolution (DYRKR) in Stereocontrolled Synthesis [0.03%]
酶促动态还原动力学拆分法(DYRKR)在立体选择性合成中的应用
Gregory A Applegate,David B Berkowitz
Gregory A Applegate
Over the past two decades, the domains of both frontline synthetic organic chemistry and process chemistry and have seen an increase in crosstalk between asymmetric organic/organometallic approaches and enzymatic approaches to stereocontrol...