Intercepting the Gold-Catalysed Meyer-Schuster Rearrangement by Controlled Protodemetallation: A Regioselective Hydration of Propargylic Alcohols [0.03%]
可控质子脱金属化拦截金催化Meyers-Schuster重排反应：炔丙醇选择性水合制烯丙醇醛的新方法
Matthew N Pennell,Michael P Kyle,Samantha M Gibson et al.
Matthew N Pennell et al.
The regioselective gold-catalysed hydration of propargylic alcohols to β-hydroxy ketones can be achieved by diverting the gold-catalysed Meyer-Schuster rearrangement through the addition of a protic additive with a pKa of 7-9 such as p-nit...
Rick C Betori,Eric R Miller,Karl A Scheidt
Rick C Betori
A novel biocatalytic system to access a wide variety of β-hydroxydioxinones from β-ketodioxinones employing commercial engineered ketoreductases has been developed. This practical system provides a remarkably straightforward solution to l...
A Methylidene Group in the Phosphonic Acid Analogue of Phenylalanine Reverses the Enantiopreference of Binding to Phenylalanine Ammonia-Lyases [0.03%]
苯氨酶结合的对映选择性可以通过模拟氨基酸中的亚甲基组逆转
Zsófia Bata,Renzhe Qian,Alexander Roller et al.
Zsófia Bata et al.
Aromatic amino acid ammonia-lyases and aromatic amino acid 2,3-aminomutases contain the post-translationally formed prosthetic 3,5-dihydro-4-methylidene-5H-imidazol-5-one (MIO) group. MIO enzymes catalyze the stereoselective synthesis of α...
Electron-Poor, Fluoro-Containing Arylboronic Acids as Efficient Coupling Partners for Bis(1,5-cyclooctadiene)nickel(0)/Tricyclohexylphosphine-Catalyzed Cross-Coupling Reactions of Aryl Arenesulfonates [0.03%]
用于芳基磺酸酯与双环辛二烯镍(0)/三异亚丙基磷催化交叉偶联反应的缺电子含氟芳基硼酸的有效偶联试剂研究
Wen-Bo Chen,Chun-Hui Xing,Jie Dong et al.
Wen-Bo Chen et al.
The use of electron-poor, fluoro-containing arylboronic acids as general coupling partners for nickel(0) /tricyclohexylphosphine-catalyzed cross-coupling of aryl arenesulfonates is described. Electron-poor fluoro-containing arylboronic acid...
Exploring the Catalytic Promiscuity of Phenolic Acid Decarboxylases: Asymmetric, 1,6-Conjugate Addition of Nucleophiles Across 4-Hydroxystyrene [0.03%]
酚酸脱羧酶催化的不对称1,6-共轭加成反应研究： nucleophile across 4-hydroxystyrene
Stefan E Payer,Xiang Sheng,Hannah Pollak et al.
Stefan E Payer et al.
The catalytic promiscuity of a ferulic acid decarboxylase from Enterobacter sp. (FDC_Es) and phenolic acid decarboxylases (PADs) for the asymmetric conjugate addition of water across the C=C bond of hydroxystyrenes was extended to the N-, C...
Total Synthesis of Viniferifuran, Resveratrol-Piceatannol Hybrid, Anigopreissin A and Analogues - Investigation of Demethylation Strategies [0.03%]
葡萄皮素、白藜芦醇-杨梅素杂合物、Anigopreissin A及类似物的全合成与脱甲基策略研究
Duc Duy Vo,Mikael Elofsson
Duc Duy Vo
Resveratrol-based natural products constitute a valuable source of unique compounds with diverse biological activities. In this report we investigate demethylation strategies to minimize formation of cyclized and dimerized products during t...
Tandem C(sp3)-H Arylation/Oxidation and Arylation/Allylic Substitution of Isoindolinones [0.03%]
异靛隆的C(sp³)-H芳基化/氧化和芳基化/烯丙基取代串联反应
Jacqueline Jiménez,Byeong-Seon Kim,Patrick J Walsh
Jacqueline Jiménez
Isoindolinones comprise an important class of medicinally active compounds. Herein we report a straightforward functionalization of the isoindolinones with aryl bromides (22 examples) using a Pd(OAc)2/NIXANTPHOS-based catalyst system. Addit...
Katharina Plasch,Verena Resch,Julien Hitce et al.
Katharina Plasch et al.
In order to extend the applicability of the regioselective enzymatic carboxylation of phenols, the substrate scope of o-benzoic acid (de)carboxylases has been investigated towards complex molecules with an emphasis on flavouring agents and ...
Property-Guided Synthesis of Aza-Tricyclic Indolines: Development of Gold Catalysis En Route [0.03%]
基于属性的氮杂三环并吲哚啉类化合物的合成及金催化研究中的发展路程
Patrick M Barbour,Wei Wang,Le Chang et al.
Patrick M Barbour et al.
Antibiotic resistance is a worldwide public health threat that needs to be addressed by improved antibiotic stewardship and continuing development of new chemical entities to treat resistant bacterial infections. Compounds that work alongsi...
Umpolung Synthesis of Diarylmethylamines via Palladium-Catalyzed Arylation of N-Benzyl Aldimines [0.03%]
钯催化N-苄基醛亚胺的芳基化反应——茋类化合物的反转合成法
Minyan Li,Baris Yucel,Jacqueline Jiménez et al.
Minyan Li et al.
An umpolung synthesis of diarylmethylamine derivatives is presented. This reaction entails a Pd catalyzed arylation of 1,3-diaryl-2-azaallyl anions, in situ generated from N-benzyl aldimines. A Pd(NIXANTPHOS)-based catalyst together with hi...