Exploring the Catalytic Promiscuity of Phenolic Acid Decarboxylases: Asymmetric, 1,6-Conjugate Addition of Nucleophiles Across 4-Hydroxystyrene [0.03%]
酚酸脱羧酶催化的不对称1,6-共轭加成反应研究： nucleophile across 4-hydroxystyrene
Stefan E Payer,Xiang Sheng,Hannah Pollak et al.
Stefan E Payer et al.
The catalytic promiscuity of a ferulic acid decarboxylase from Enterobacter sp. (FDC_Es) and phenolic acid decarboxylases (PADs) for the asymmetric conjugate addition of water across the C=C bond of hydroxystyrenes was extended to the N-, C...
Total Synthesis of Viniferifuran, Resveratrol-Piceatannol Hybrid, Anigopreissin A and Analogues - Investigation of Demethylation Strategies [0.03%]
葡萄皮素、白藜芦醇-杨梅素杂合物、Anigopreissin A及类似物的全合成与脱甲基策略研究
Duc Duy Vo,Mikael Elofsson
Duc Duy Vo
Resveratrol-based natural products constitute a valuable source of unique compounds with diverse biological activities. In this report we investigate demethylation strategies to minimize formation of cyclized and dimerized products during t...
Tandem C(sp3)-H Arylation/Oxidation and Arylation/Allylic Substitution of Isoindolinones [0.03%]
异靛隆的C(sp³)-H芳基化/氧化和芳基化/烯丙基取代串联反应
Jacqueline Jiménez,Byeong-Seon Kim,Patrick J Walsh
Jacqueline Jiménez
Isoindolinones comprise an important class of medicinally active compounds. Herein we report a straightforward functionalization of the isoindolinones with aryl bromides (22 examples) using a Pd(OAc)2/NIXANTPHOS-based catalyst system. Addit...
Katharina Plasch,Verena Resch,Julien Hitce et al.
Katharina Plasch et al.
In order to extend the applicability of the regioselective enzymatic carboxylation of phenols, the substrate scope of o-benzoic acid (de)carboxylases has been investigated towards complex molecules with an emphasis on flavouring agents and ...
Property-Guided Synthesis of Aza-Tricyclic Indolines: Development of Gold Catalysis En Route [0.03%]
基于属性的氮杂三环并吲哚啉类化合物的合成及金催化研究中的发展路程
Patrick M Barbour,Wei Wang,Le Chang et al.
Patrick M Barbour et al.
Antibiotic resistance is a worldwide public health threat that needs to be addressed by improved antibiotic stewardship and continuing development of new chemical entities to treat resistant bacterial infections. Compounds that work alongsi...
Umpolung Synthesis of Diarylmethylamines via Palladium-Catalyzed Arylation of N-Benzyl Aldimines [0.03%]
钯催化N-苄基醛亚胺的芳基化反应——茋类化合物的反转合成法
Minyan Li,Baris Yucel,Jacqueline Jiménez et al.
Minyan Li et al.
An umpolung synthesis of diarylmethylamine derivatives is presented. This reaction entails a Pd catalyzed arylation of 1,3-diaryl-2-azaallyl anions, in situ generated from N-benzyl aldimines. A Pd(NIXANTPHOS)-based catalyst together with hi...
Synthesis of Functionalized Hydrazines: Facile Homogeneous (N-Heterocyclic Carbene)-Palladium(0)-Catalyzed Diboration and Silaboration of Azobenzenes [0.03%]
功能化胲的合成：偶氮苯的选择性双硼化和硅硼化的简便均相[N-杂环卡宾]钯(0)催化体系
Melvyn B Ansell,George E Kostakis,Holger Braunschweig et al.
Melvyn B Ansell et al.
The bis(N-heterocyclic carbene)(diphenylacetylene)palladium complex [Pd(ITMe)2(PhC≡CPh)] (ITMe=1,3,4,5-tetramethylimidazol-2-ylidene) acts as a highly active pre-catalyst in the diboration and silaboration of azobenzenes to synthesize a se...
Palladium-Catalyzed α-Arylation of Methyl Sulfonamides with Aryl Chlorides [0.03%]
钯催化甲磺酰胺与芳基氯的α-arylation反应
Bing Zheng,Minyan Li,Gui Gao et al.
Bing Zheng et al.
A Palladium-catalyzed α-arylation of sulfonamides with aryl chlorides is presented. A Buchwald type precatalyst formed with Kwong's indole-based ligand enabled this transformation to be compatible with a large variety of methyl sulfonamide...
Selective Enzymatic Transformation to Aldehydes in vivo by Fungal Carboxylate Reductase from Neurospora crassa [0.03%]
Neurospora crassa真菌羧酸还原酶在 vivo 选择性催化醇和酯向醛的生物转化
Daniel Schwendenwein,Giuseppe Fiume,Hansjörg Weber et al.
Daniel Schwendenwein et al.
The enzymatic reduction of carboxylic acids is in its infancy with only a handful of biocatalysts available to this end. We have increased the spectrum of carboxylate-reducing enzymes (CARs) with the sequence of a fungal CAR from Neurospora...
A Ruthenium Catalyst for Olefin Metathesis Featuring an Anti-Bredt N-Heterocyclic Carbene Ligand [0.03%]
一个含有反Bredt N-杂环卡宾配体的钌催化剂应用于烯烃复分解反应
David Martin,Vanessa M Marx,Robert H Grubbs et al.
David Martin et al.
A ruthenium complex bearing an "anti-Bredt" N-heterocyclic carbene was synthesized, characterized and evaluated as a catalyst for olefin metathesis. Good conversions were observed at room temperature for the formation of di- and tri-substit...