Tandem C(sp3)-H Arylation/Oxidation and Arylation/Allylic Substitution of Isoindolinones
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Isoindolinones comprise an important class of medicinally active compounds. Herein we report a straightforward functionalization of the isoindolinones with aryl bromides (22 examples) using a Pd(OAc)2/NIXANTPHOS-based catalyst system. Additionally 3-aryl 3-hyd... ...
