Direct Reductive Amination of Carbonyl Compounds Catalyzed by a Moisture Tolerant Tin(IV) Lewis Acid [0.03%]
一种耐水的路易斯酸tin(IV)催化醛酮类化合物直接加氢胺化反应
Joshua S Sapsford,Daniel J Scott,Nathan J Allcock et al.
Joshua S Sapsford et al.
Despite the ever-broadening applications of main-group 'frustrated Lewis pair' (FLP) chemistry to both new and established reactions, their typical intolerance of water, especially at elevated temperatures (>100 °C), represents a key barri...
Metal Substitution Modulates the Reactivity and Extends the Reaction Scope of Myoglobin Carbene Transfer Catalysts [0.03%]
金属替代调节肌红蛋白卡宾转移催化剂的反应活性并扩大其反应范围
Gopeekrishnan Sreenilayam,Eric J Moore,Viktoria Steck et al.
Gopeekrishnan Sreenilayam et al.
Engineered myoglobins have recently emerged as promising scaffolds for catalyzing carbene-mediated transformations. In this work, we investigated the effect of altering the metal center and its first-sphere coordination environment on the c...
Arylation of Azaarylmethylamines with Aryl Chlorides and a NiBr2/NIXANTPHOS-based Catalyst [0.03%]
镍催化剂促进的芳基氯化物与亚胺𬭩甲基胺类化合物的偶联反应
Gui Gao,Yue Fu,Minyan Li et al.
Gui Gao et al.
A nickel-catalyzed coupling of azaarylmethylamines with aryl chlorides has been achieved. NIXANTPHOS together with low cost NiBr2 was successfully developed and optimized to exhibit high reactivity at 2.5 mol % loading. Under optimized reac...
Gold-catalyzed Fluorination of Alkynyl Esters and Ketones: Efficient Access to Fluorinated 1,3-Dicarbonyl Compounds [0.03%]
金催化炔基酯和酮的氟化反应：制备含氟1,3-二羰基化合物的有效方法
Xiaojun Zeng,Zhichao Lu,Shiwen Liu et al.
Xiaojun Zeng et al.
We developed an efficient synthesis of 2-fluoro-1,3-dicarbonyl compounds using readily available alkynyl ketones or esters as starting material. The key step is the insertion of hydrogen fluoride (HF) to the gold carbene intermediate genera...
The Palladium Acetate-Catalyzed Microwave-Assisted Hirao Reaction without an Added Phosphorus Ligand as a "Green" Protocol: A Quantum Chemical Study on the Mechanism [0.03%]
无配体膦的钯醋酸盐催化的Hirao反应的“绿色”协议：关于机理的量子化学研究
György Keglevich,Réka Henyecz,Zoltán Mucsi et al.
György Keglevich et al.
It was proved by our experiments that on microwave irradiation, the mono- or bidentate phosphorus ligands generally applied in the palladium(II)-catalyzed P-C coupling reaction of aryl bromides and dialkyl phosphites or secondary phosphine ...
Synthesis of Diarylated 4-Pyridylmethyl Ethers via Palladium-Catalyzed Cross-Coupling Reactions [0.03%]
钯催化交叉偶联反应合成二芳基化吡啶甲基醚类化合物
Keyume Ablajan,Grace B Panetti,Xiaodong Yang et al.
Keyume Ablajan et al.
The direct arylation of weakly acidic sp3-hybridized C-H bonds via deprotonated cross-coupling processes (DCCP) is a challenge. Herein, a Pd(NIXANTPHOS)-based catalyst for the mono arylation of 4-pyridylmethyl 2-aryl ethers to generate diar...
Intercepting the Gold-Catalysed Meyer-Schuster Rearrangement by Controlled Protodemetallation: A Regioselective Hydration of Propargylic Alcohols [0.03%]
可控质子脱金属化拦截金催化Meyers-Schuster重排反应：炔丙醇选择性水合制烯丙醇醛的新方法
Matthew N Pennell,Michael P Kyle,Samantha M Gibson et al.
Matthew N Pennell et al.
The regioselective gold-catalysed hydration of propargylic alcohols to β-hydroxy ketones can be achieved by diverting the gold-catalysed Meyer-Schuster rearrangement through the addition of a protic additive with a pKa of 7-9 such as p-nit...
Rick C Betori,Eric R Miller,Karl A Scheidt
Rick C Betori
A novel biocatalytic system to access a wide variety of β-hydroxydioxinones from β-ketodioxinones employing commercial engineered ketoreductases has been developed. This practical system provides a remarkably straightforward solution to l...
A Methylidene Group in the Phosphonic Acid Analogue of Phenylalanine Reverses the Enantiopreference of Binding to Phenylalanine Ammonia-Lyases [0.03%]
苯氨酶结合的对映选择性可以通过模拟氨基酸中的亚甲基组逆转
Zsófia Bata,Renzhe Qian,Alexander Roller et al.
Zsófia Bata et al.
Aromatic amino acid ammonia-lyases and aromatic amino acid 2,3-aminomutases contain the post-translationally formed prosthetic 3,5-dihydro-4-methylidene-5H-imidazol-5-one (MIO) group. MIO enzymes catalyze the stereoselective synthesis of α...
Electron-Poor, Fluoro-Containing Arylboronic Acids as Efficient Coupling Partners for Bis(1,5-cyclooctadiene)nickel(0)/Tricyclohexylphosphine-Catalyzed Cross-Coupling Reactions of Aryl Arenesulfonates [0.03%]
用于芳基磺酸酯与双环辛二烯镍(0)/三异亚丙基磷催化交叉偶联反应的缺电子含氟芳基硼酸的有效偶联试剂研究
Wen-Bo Chen,Chun-Hui Xing,Jie Dong et al.
Wen-Bo Chen et al.
The use of electron-poor, fluoro-containing arylboronic acids as general coupling partners for nickel(0) /tricyclohexylphosphine-catalyzed cross-coupling of aryl arenesulfonates is described. Electron-poor fluoro-containing arylboronic acid...