The Palladium Acetate-Catalyzed Microwave-Assisted Hirao Reaction without an Added Phosphorus Ligand as a "Green" Protocol: A Quantum Chemical Study on the Mechanism [0.03%]
无配体膦的钯醋酸盐催化的Hirao反应的“绿色”协议：关于机理的量子化学研究
György Keglevich,Réka Henyecz,Zoltán Mucsi et al.
György Keglevich et al.
It was proved by our experiments that on microwave irradiation, the mono- or bidentate phosphorus ligands generally applied in the palladium(II)-catalyzed P-C coupling reaction of aryl bromides and dialkyl phosphites or secondary phosphine ...
Synthesis of Diarylated 4-Pyridylmethyl Ethers via Palladium-Catalyzed Cross-Coupling Reactions [0.03%]
钯催化交叉偶联反应合成二芳基化吡啶甲基醚类化合物
Keyume Ablajan,Grace B Panetti,Xiaodong Yang et al.
Keyume Ablajan et al.
The direct arylation of weakly acidic sp3-hybridized C-H bonds via deprotonated cross-coupling processes (DCCP) is a challenge. Herein, a Pd(NIXANTPHOS)-based catalyst for the mono arylation of 4-pyridylmethyl 2-aryl ethers to generate diar...
Intercepting the Gold-Catalysed Meyer-Schuster Rearrangement by Controlled Protodemetallation: A Regioselective Hydration of Propargylic Alcohols [0.03%]
可控质子脱金属化拦截金催化Meyers-Schuster重排反应：炔丙醇选择性水合制烯丙醇醛的新方法
Matthew N Pennell,Michael P Kyle,Samantha M Gibson et al.
Matthew N Pennell et al.
The regioselective gold-catalysed hydration of propargylic alcohols to β-hydroxy ketones can be achieved by diverting the gold-catalysed Meyer-Schuster rearrangement through the addition of a protic additive with a pKa of 7-9 such as p-nit...
Rick C Betori,Eric R Miller,Karl A Scheidt
Rick C Betori
A novel biocatalytic system to access a wide variety of β-hydroxydioxinones from β-ketodioxinones employing commercial engineered ketoreductases has been developed. This practical system provides a remarkably straightforward solution to l...
A Methylidene Group in the Phosphonic Acid Analogue of Phenylalanine Reverses the Enantiopreference of Binding to Phenylalanine Ammonia-Lyases [0.03%]
苯氨酶结合的对映选择性可以通过模拟氨基酸中的亚甲基组逆转
Zsófia Bata,Renzhe Qian,Alexander Roller et al.
Zsófia Bata et al.
Aromatic amino acid ammonia-lyases and aromatic amino acid 2,3-aminomutases contain the post-translationally formed prosthetic 3,5-dihydro-4-methylidene-5H-imidazol-5-one (MIO) group. MIO enzymes catalyze the stereoselective synthesis of α...
Electron-Poor, Fluoro-Containing Arylboronic Acids as Efficient Coupling Partners for Bis(1,5-cyclooctadiene)nickel(0)/Tricyclohexylphosphine-Catalyzed Cross-Coupling Reactions of Aryl Arenesulfonates [0.03%]
用于芳基磺酸酯与双环辛二烯镍(0)/三异亚丙基磷催化交叉偶联反应的缺电子含氟芳基硼酸的有效偶联试剂研究
Wen-Bo Chen,Chun-Hui Xing,Jie Dong et al.
Wen-Bo Chen et al.
The use of electron-poor, fluoro-containing arylboronic acids as general coupling partners for nickel(0) /tricyclohexylphosphine-catalyzed cross-coupling of aryl arenesulfonates is described. Electron-poor fluoro-containing arylboronic acid...
Exploring the Catalytic Promiscuity of Phenolic Acid Decarboxylases: Asymmetric, 1,6-Conjugate Addition of Nucleophiles Across 4-Hydroxystyrene [0.03%]
酚酸脱羧酶催化的不对称1,6-共轭加成反应研究： nucleophile across 4-hydroxystyrene
Stefan E Payer,Xiang Sheng,Hannah Pollak et al.
Stefan E Payer et al.
The catalytic promiscuity of a ferulic acid decarboxylase from Enterobacter sp. (FDC_Es) and phenolic acid decarboxylases (PADs) for the asymmetric conjugate addition of water across the C=C bond of hydroxystyrenes was extended to the N-, C...
Total Synthesis of Viniferifuran, Resveratrol-Piceatannol Hybrid, Anigopreissin A and Analogues - Investigation of Demethylation Strategies [0.03%]
葡萄皮素、白藜芦醇-杨梅素杂合物、Anigopreissin A及类似物的全合成与脱甲基策略研究
Duc Duy Vo,Mikael Elofsson
Duc Duy Vo
Resveratrol-based natural products constitute a valuable source of unique compounds with diverse biological activities. In this report we investigate demethylation strategies to minimize formation of cyclized and dimerized products during t...
Tandem C(sp3)-H Arylation/Oxidation and Arylation/Allylic Substitution of Isoindolinones [0.03%]
异靛隆的C(sp³)-H芳基化/氧化和芳基化/烯丙基取代串联反应
Jacqueline Jiménez,Byeong-Seon Kim,Patrick J Walsh
Jacqueline Jiménez
Isoindolinones comprise an important class of medicinally active compounds. Herein we report a straightforward functionalization of the isoindolinones with aryl bromides (22 examples) using a Pd(OAc)2/NIXANTPHOS-based catalyst system. Addit...
Katharina Plasch,Verena Resch,Julien Hitce et al.
Katharina Plasch et al.
In order to extend the applicability of the regioselective enzymatic carboxylation of phenols, the substrate scope of o-benzoic acid (de)carboxylases has been investigated towards complex molecules with an emphasis on flavouring agents and ...