A Cooperative Ternary Catalysis System for Asymmetric Lactonizations of α-Ketoesters [0.03%]
α-酮酸酯的不对称 lactonization 反应的三组分协同催化体系
Kathleen J R Murauski,Daniel M Walden,Paul Ha-Yeon Cheong et al.
Kathleen J R Murauski et al.
A general and enantioselective N-heterocyclic carbene (NHC)-catalyzed lactonization of simple enals and α-ketoesters has been discovered using a new ternary cooperative catalytic system. The highly selective annulation was achieved by usin...
Visible-Light-Mediated Photoredox-Catalyzed N-Arylation of NH-Sulfoximines with Electron-Rich Arenes [0.03%]
富电子芳烃的NH-亚砜亚胺的光氧化还原催化可见光介导的N-芳基化反应
Alexander Wimmer,Burkhard König
Alexander Wimmer
The direct C-H/N-H dehydrogenative cross-coupling of NH-sulfoximines with electron-rich arenes was realized by oxidative visible-light photoredox catalysis, applying 9-mesityl-10-methylacridinium perchlorate as an organic photocatalyst. Sul...
Evaluation of Natural and Synthetic Phosphate Donors for the Improved Enzymatic Synthesis of Phosphate Monoesters [0.03%]
评估天然和合成磷酸供体以改进酶法合成磷单酯的效果
Gábor Tasnádi,Wolfgang Jud,Mélanie Hall et al.
Gábor Tasnádi et al.
Undesired product hydrolysis along with large amounts of waste in form of inorganic monophosphate by-product are the main obstacles associated with the use of pyrophosphate in the phosphatase-catalyzed synthesis of phosphate monoesters on l...
Biocatalytic Parallel Interconnected Dynamic Asymmetric Disproportionation of α-Substituted Aldehydes: Atom-Efficient Access to Enantiopure (S)-Profens and Profenols [0.03%]
α-取代醛的生物催化并联互联动态动力学拆分：(S)-普瑞酚和普瑞酚醇纯对映体原子经济性合成的新途径
Erika Tassano,Kurt Faber,Mélanie Hall
Erika Tassano
The biocatalytic asymmetric disproportionation of aldehydes catalyzed by horse liver alcohol dehydrogenase (HLADH) was assessed in detail on a series of racemic 2-arylpropanals. Statistical optimization by means of design of experiments (Do...
Combining Sanford Arylations on Benzodiazepines with the Nuisance Effect [0.03%]
苯并二氮杂卓的Sanford偶联以及副反应效应
Raysa Khan,Sarote Boonseng,Paul D Kemmitt et al.
Raysa Khan et al.
5-Phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-ones react under palladium- and visible light photoredox catalysis, in refluxing methanol, with aryldiazonium salts to afford the respective 5-(2-arylphenyl) analogues. With 2- or 4-fluorobenzened...
Palladium-Catalyzed Triarylation of sp3 C-H Bonds in Heteroarylmethanes: Synthesis of Triaryl(heteroaryl)methanes [0.03%]
钯催化杂芳基甲烷sp3C-H键的三芳基化反应：三芳基(杂芳基)甲烷的合成
Shuguang Zhang,Bowen Hu,Zhipeng Zheng et al.
Shuguang Zhang et al.
A straightforward method for the palladium-catalyzed triarylation of heteroarylmethanes at the methyl group has been developed. The reaction works with a variety of aryl halides, enabling the rapid synthesis of triaryl(heteroaryl)methanes i...
NAD(P)H-Dependent Dehydrogenases for the Asymmetric Reductive Amination of Ketones: Structure, Mechanism, Evolution and Application [0.03%]
用于酮不对称还原胺化的NAD(P)H依赖性脱氢酶：结构、机制、进化和应用
Mahima Sharma,Juan Mangas-Sanchez,Nicholas J Turner et al.
Mahima Sharma et al.
Asymmetric reductive aminations are some of the most important reactions in the preparation of active pharmaceuticals, as chiral amines feature in many of the world's most important drugs. Although many enzymes have been applied to the synt...
Chemoenzymatic Approaches to the Synthesis of the Calcimimetic Agent Cinacalcet Employing Transaminases and Ketoreductases [0.03%]
采用转氨酶和酮还原酶催化手性胺合成钙敏化剂西那卡塞的化学-酶法策略
Lisa Marx,Nicolás Ríos-Lombardía,Judith F Farnberger et al.
Lisa Marx et al.
Several chemoenzymatic routes have been explored for the preparation of cinacalcet, a calcimimetic agent. Transaminases (TAs) and ketoreductases (KREDs) turned out to be useful biocatalysts for the preparation of key optically active precur...
A Simple Procedure for the Synthesis of β-Hydroxyallenamides via Homoallenylation of Aldehydes [0.03%]
醛的 homo-allenylation 反应制备β-羟基烯氨基甲酸酯的方法
Byeong-Seon Kim,Osvaldo Gutierrez,Marisa C Kozlowski et al.
Byeong-Seon Kim et al.
A simple one-pot synthesis of β-hydroxyallenamides is reported. This procedure entails chemo- and regioselective hydroboration of 3-en-1-ynyl-sulfonylamides with Cy2BH followed by homoallenylation of aldehydes to yield β-hydroxyallenamide...
Stereoselective Synthesis of 3,3'-Bisindolines by Organocatalytic Michael Additions of Fluorooxindole Enolates to Isatylidene Malononitriles in Aqueous Solution [0.03%]
水溶液中有机催化氟代呫吨酮烯醇酯与异噁酰基氰化钾的迈克尔加成及3,3'-联吲哚啉的立体选择性合成
Kaluvu Balaraman,Ransheng Ding,Christian Wolf
Kaluvu Balaraman
A highly diastereoselective organocatalytic reaction for the synthesis of fluorinated 3,3'-bisindolines exhibiting adjacent tetrasubstituted carbon stereocenters is described. A broad variety of heterochiral bisindolines was prepared in 91-...