Combining Sanford Arylations on Benzodiazepines with the Nuisance Effect [0.03%]
苯并二氮杂卓的Sanford偶联以及副反应效应
Raysa Khan,Sarote Boonseng,Paul D Kemmitt et al.
Raysa Khan et al.
5-Phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-ones react under palladium- and visible light photoredox catalysis, in refluxing methanol, with aryldiazonium salts to afford the respective 5-(2-arylphenyl) analogues. With 2- or 4-fluorobenzened...
Palladium-Catalyzed Triarylation of sp3 C-H Bonds in Heteroarylmethanes: Synthesis of Triaryl(heteroaryl)methanes [0.03%]
钯催化杂芳基甲烷sp3C-H键的三芳基化反应：三芳基(杂芳基)甲烷的合成
Shuguang Zhang,Bowen Hu,Zhipeng Zheng et al.
Shuguang Zhang et al.
A straightforward method for the palladium-catalyzed triarylation of heteroarylmethanes at the methyl group has been developed. The reaction works with a variety of aryl halides, enabling the rapid synthesis of triaryl(heteroaryl)methanes i...
NAD(P)H-Dependent Dehydrogenases for the Asymmetric Reductive Amination of Ketones: Structure, Mechanism, Evolution and Application [0.03%]
用于酮不对称还原胺化的NAD(P)H依赖性脱氢酶：结构、机制、进化和应用
Mahima Sharma,Juan Mangas-Sanchez,Nicholas J Turner et al.
Mahima Sharma et al.
Asymmetric reductive aminations are some of the most important reactions in the preparation of active pharmaceuticals, as chiral amines feature in many of the world's most important drugs. Although many enzymes have been applied to the synt...
Chemoenzymatic Approaches to the Synthesis of the Calcimimetic Agent Cinacalcet Employing Transaminases and Ketoreductases [0.03%]
采用转氨酶和酮还原酶催化手性胺合成钙敏化剂西那卡塞的化学-酶法策略
Lisa Marx,Nicolás Ríos-Lombardía,Judith F Farnberger et al.
Lisa Marx et al.
Several chemoenzymatic routes have been explored for the preparation of cinacalcet, a calcimimetic agent. Transaminases (TAs) and ketoreductases (KREDs) turned out to be useful biocatalysts for the preparation of key optically active precur...
A Simple Procedure for the Synthesis of β-Hydroxyallenamides via Homoallenylation of Aldehydes [0.03%]
醛的 homo-allenylation 反应制备β-羟基烯氨基甲酸酯的方法
Byeong-Seon Kim,Osvaldo Gutierrez,Marisa C Kozlowski et al.
Byeong-Seon Kim et al.
A simple one-pot synthesis of β-hydroxyallenamides is reported. This procedure entails chemo- and regioselective hydroboration of 3-en-1-ynyl-sulfonylamides with Cy2BH followed by homoallenylation of aldehydes to yield β-hydroxyallenamide...
Stereoselective Synthesis of 3,3'-Bisindolines by Organocatalytic Michael Additions of Fluorooxindole Enolates to Isatylidene Malononitriles in Aqueous Solution [0.03%]
水溶液中有机催化氟代呫吨酮烯醇酯与异噁酰基氰化钾的迈克尔加成及3,3'-联吲哚啉的立体选择性合成
Kaluvu Balaraman,Ransheng Ding,Christian Wolf
Kaluvu Balaraman
A highly diastereoselective organocatalytic reaction for the synthesis of fluorinated 3,3'-bisindolines exhibiting adjacent tetrasubstituted carbon stereocenters is described. A broad variety of heterochiral bisindolines was prepared in 91-...
Direct Reductive Amination of Carbonyl Compounds Catalyzed by a Moisture Tolerant Tin(IV) Lewis Acid [0.03%]
一种耐水的路易斯酸tin(IV)催化醛酮类化合物直接加氢胺化反应
Joshua S Sapsford,Daniel J Scott,Nathan J Allcock et al.
Joshua S Sapsford et al.
Despite the ever-broadening applications of main-group 'frustrated Lewis pair' (FLP) chemistry to both new and established reactions, their typical intolerance of water, especially at elevated temperatures (>100 °C), represents a key barri...
Metal Substitution Modulates the Reactivity and Extends the Reaction Scope of Myoglobin Carbene Transfer Catalysts [0.03%]
金属替代调节肌红蛋白卡宾转移催化剂的反应活性并扩大其反应范围
Gopeekrishnan Sreenilayam,Eric J Moore,Viktoria Steck et al.
Gopeekrishnan Sreenilayam et al.
Engineered myoglobins have recently emerged as promising scaffolds for catalyzing carbene-mediated transformations. In this work, we investigated the effect of altering the metal center and its first-sphere coordination environment on the c...
Arylation of Azaarylmethylamines with Aryl Chlorides and a NiBr2/NIXANTPHOS-based Catalyst [0.03%]
镍催化剂促进的芳基氯化物与亚胺𬭩甲基胺类化合物的偶联反应
Gui Gao,Yue Fu,Minyan Li et al.
Gui Gao et al.
A nickel-catalyzed coupling of azaarylmethylamines with aryl chlorides has been achieved. NIXANTPHOS together with low cost NiBr2 was successfully developed and optimized to exhibit high reactivity at 2.5 mol % loading. Under optimized reac...
Gold-catalyzed Fluorination of Alkynyl Esters and Ketones: Efficient Access to Fluorinated 1,3-Dicarbonyl Compounds [0.03%]
金催化炔基酯和酮的氟化反应：制备含氟1,3-二羰基化合物的有效方法
Xiaojun Zeng,Zhichao Lu,Shiwen Liu et al.
Xiaojun Zeng et al.
We developed an efficient synthesis of 2-fluoro-1,3-dicarbonyl compounds using readily available alkynyl ketones or esters as starting material. The key step is the insertion of hydrogen fluoride (HF) to the gold carbene intermediate genera...