Progress in Difluoroalkylation of Organic Substrates by Visible Light Photoredox Catalysis [0.03%]
可见光促进的有机底物双氟烷基化反应研究进展
Agostinho Lemos,Christian Lemaire,André Luxen
Agostinho Lemos
The selective incorporation of fluorinated motifs, in particular CF2FG (FG=a functional group) and CF2H groups, into organic compounds has attrracted increasing attention since organofluorine molecules are of the utmost importance in the ar...
Aldolase-Catalyzed Asymmetric Synthesis of N-Heterocycles by Addition of Simple Aliphatic Nucleophiles to Aminoaldehydes [0.03%]
醛缩酶催化简单脂肪族亲核试剂与氨基甲醛的加成反应构建手性N-杂环化合物
Raquel Roldán,Karel Hernández,Jesús Joglar et al.
Raquel Roldán et al.
Nitrogen heterocycles are structural motifs found in many bioactive natural products and of utmost importance in pharmaceutical drug development. In this work, a stereoselective synthesis of functionalized N-heterocycles was accomplished in...
Chemoenzymatic Synthesis of Sialic Acid Derivatives Using Immobilized N- Acetylneuraminate Lyase in a Continuous Flow Reactor [0.03%]
固定化N-乙酰神经氨酸酶在连续流动反应器中合成唾液酸衍生物的化学酶法
Victor R L J Bloemendal,Sam J Moons,Jurriaan J A Heming et al.
Victor R L J Bloemendal et al.
The synthesis of N-acetylneuraminic acid (Neu5Ac) derivatives is drawing more and more attention in glycobiology research because of the important role of sialic acids in e. g. cancer, bacterial, and healthy cells. Chemical preparation of t...
Stereoselective Synthesis of 3-Oxabicyclo[3.3.1]nonan-2-ones via a Domino Reaction Catalyzed by Modularly Designed Organocatalysts [0.03%]
模块化设计 organocatalysts催化的串联反应合成3-氧杂双环[3.3.1]壬内酮类化合物的立体选择性合成研究
Ramarao Parella,Satish Jakkampudi,Hadi Arman et al.
Ramarao Parella et al.
A highly stereoselective method for the synthesis of functionalized 3-oxabicyclo[3.3.1]nonan-2-one derivatives with four contiguous stereogenic centers, including one tetrasubstituted stereogenic center, was realized through an organocataly...
Non-Oxidative Enzymatic (De)Carboxylation of (Hetero)Aromatics and Acrylic Acid Derivatives [0.03%]
杂环芳烃和丙烯酸衍生物的非氧化酶脱羧/加羧反应
Stefan E Payer,Kurt Faber,Silvia M Glueck
Stefan E Payer
The utilization of carbon dioxide as a C1-building block for the production of valuable chemicals has recently attracted much interest. Whereas chemical CO2 fixation is dominated by C-O and C-N bond forming reactions, the development of nov...
Organocatalytic Decarboxylative Cyanomethylation of Difluoromethyl and Trifluoromethyl Ketones [0.03%]
二氟甲基和三氟甲基酮的有机催化脱羧氰甲基化反应
Kaluvu Balaraman,Max Moskowitz,Christian Wolf
Kaluvu Balaraman
An efficient organocatalytic method for the synthesis of difluoromethyl and trifluoromethyl substituted β-hydroxynitriles is introduced. The decarboxylative cyanomethylation of fluorinated ketones with readily available cyanoacetic acid gi...
An Enzymatic 2-Step Cofactor and Co-Product Recycling Cascade towards a Chiral 1,2-Diol. Part I: Cascade Design [0.03%]
用于手性1,2-二醇合成的酶催化辅因子和副产物循环级联反应体系设计(I)
Justyna Kulig,Torsten Sehl,Ursula Mackfeld et al.
Justyna Kulig et al.
Alcohol dehydrogenases are of high interest for stereoselective syntheses of chiral building blocks such as 1,2-diols. As this class of enzymes requires nicotinamide cofactors, their application in biotechnological synthesis reactions is ec...
Stimulus-Responsive Regulation of Enzyme Activity for One-Step and Multi-Step Syntheses [0.03%]
刺激响应型酶活性调节用于一步及多步合成反应
Christiane Claaßen,Tim Gerlach,Dörte Rother
Christiane Claaßen
Multi-step biocatalytic reactions have gained increasing importance in recent years because the combination of different enzymes enables the synthesis of a broad variety of industrially relevant products. However, the more enzymes combined,...
The Disappearing Director: The Case of Directed N-Arylation via a Removable Hydroxyl Group [0.03%]
可移除羟基介导的导向偶联反应体系中的“消失”导向原子现象研究
Magdalena R Andrzejewska,Prasanna K Vuram,Narender Pottabathini et al.
Magdalena R Andrzejewska et al.
A facile and broadly applicable method for the regiospecific N-arylation of benzotriazoles is reported. Copper-mediated reactions of diverse 1-hydroxy-1H-benzotriazoles with aryl boronic acids lead to 1-aryl-1H-benzotriazole 3-oxides. A N1-...
Alteration of Chain Length Selectivity of Candida antarctica Lipase A by Semi-Rational Design for the Enrichment of Erucic and Gondoic Fatty Acids [0.03%]
通过半理性设计改变南极假丝酵母脂肪酶A的链长选择性以富集月桂酸和桐酸
Katja Zorn,Isabel Oroz-Guinea,Henrike Brundiek et al.
Katja Zorn et al.
Biotechnological strategies using renewable materials as starting substrates are a promising alternative to traditional oleochemical processes for the isolation of different fatty acids. Among them, long chain mono-unsaturated fatty acids a...