Non-Oxidative Enzymatic (De)Carboxylation of (Hetero)Aromatics and Acrylic Acid Derivatives [0.03%]
杂环芳烃和丙烯酸衍生物的非氧化酶脱羧/加羧反应
Stefan E Payer,Kurt Faber,Silvia M Glueck
Stefan E Payer
The utilization of carbon dioxide as a C1-building block for the production of valuable chemicals has recently attracted much interest. Whereas chemical CO2 fixation is dominated by C-O and C-N bond forming reactions, the development of nov...
Organocatalytic Decarboxylative Cyanomethylation of Difluoromethyl and Trifluoromethyl Ketones [0.03%]
二氟甲基和三氟甲基酮的有机催化脱羧氰甲基化反应
Kaluvu Balaraman,Max Moskowitz,Christian Wolf
Kaluvu Balaraman
An efficient organocatalytic method for the synthesis of difluoromethyl and trifluoromethyl substituted β-hydroxynitriles is introduced. The decarboxylative cyanomethylation of fluorinated ketones with readily available cyanoacetic acid gi...
An Enzymatic 2-Step Cofactor and Co-Product Recycling Cascade towards a Chiral 1,2-Diol. Part I: Cascade Design [0.03%]
用于手性1,2-二醇合成的酶催化辅因子和副产物循环级联反应体系设计(I)
Justyna Kulig,Torsten Sehl,Ursula Mackfeld et al.
Justyna Kulig et al.
Alcohol dehydrogenases are of high interest for stereoselective syntheses of chiral building blocks such as 1,2-diols. As this class of enzymes requires nicotinamide cofactors, their application in biotechnological synthesis reactions is ec...
Stimulus-Responsive Regulation of Enzyme Activity for One-Step and Multi-Step Syntheses [0.03%]
刺激响应型酶活性调节用于一步及多步合成反应
Christiane Claaßen,Tim Gerlach,Dörte Rother
Christiane Claaßen
Multi-step biocatalytic reactions have gained increasing importance in recent years because the combination of different enzymes enables the synthesis of a broad variety of industrially relevant products. However, the more enzymes combined,...
The Disappearing Director: The Case of Directed N-Arylation via a Removable Hydroxyl Group [0.03%]
可移除羟基介导的导向偶联反应体系中的“消失”导向原子现象研究
Magdalena R Andrzejewska,Prasanna K Vuram,Narender Pottabathini et al.
Magdalena R Andrzejewska et al.
A facile and broadly applicable method for the regiospecific N-arylation of benzotriazoles is reported. Copper-mediated reactions of diverse 1-hydroxy-1H-benzotriazoles with aryl boronic acids lead to 1-aryl-1H-benzotriazole 3-oxides. A N1-...
Alteration of Chain Length Selectivity of Candida antarctica Lipase A by Semi-Rational Design for the Enrichment of Erucic and Gondoic Fatty Acids [0.03%]
通过半理性设计改变南极假丝酵母脂肪酶A的链长选择性以富集月桂酸和桐酸
Katja Zorn,Isabel Oroz-Guinea,Henrike Brundiek et al.
Katja Zorn et al.
Biotechnological strategies using renewable materials as starting substrates are a promising alternative to traditional oleochemical processes for the isolation of different fatty acids. Among them, long chain mono-unsaturated fatty acids a...
A Cooperative Ternary Catalysis System for Asymmetric Lactonizations of α-Ketoesters [0.03%]
α-酮酸酯的不对称 lactonization 反应的三组分协同催化体系
Kathleen J R Murauski,Daniel M Walden,Paul Ha-Yeon Cheong et al.
Kathleen J R Murauski et al.
A general and enantioselective N-heterocyclic carbene (NHC)-catalyzed lactonization of simple enals and α-ketoesters has been discovered using a new ternary cooperative catalytic system. The highly selective annulation was achieved by usin...
Visible-Light-Mediated Photoredox-Catalyzed N-Arylation of NH-Sulfoximines with Electron-Rich Arenes [0.03%]
富电子芳烃的NH-亚砜亚胺的光氧化还原催化可见光介导的N-芳基化反应
Alexander Wimmer,Burkhard König
Alexander Wimmer
The direct C-H/N-H dehydrogenative cross-coupling of NH-sulfoximines with electron-rich arenes was realized by oxidative visible-light photoredox catalysis, applying 9-mesityl-10-methylacridinium perchlorate as an organic photocatalyst. Sul...
Evaluation of Natural and Synthetic Phosphate Donors for the Improved Enzymatic Synthesis of Phosphate Monoesters [0.03%]
评估天然和合成磷酸供体以改进酶法合成磷单酯的效果
Gábor Tasnádi,Wolfgang Jud,Mélanie Hall et al.
Gábor Tasnádi et al.
Undesired product hydrolysis along with large amounts of waste in form of inorganic monophosphate by-product are the main obstacles associated with the use of pyrophosphate in the phosphatase-catalyzed synthesis of phosphate monoesters on l...
Biocatalytic Parallel Interconnected Dynamic Asymmetric Disproportionation of α-Substituted Aldehydes: Atom-Efficient Access to Enantiopure (S)-Profens and Profenols [0.03%]
α-取代醛的生物催化并联互联动态动力学拆分：(S)-普瑞酚和普瑞酚醇纯对映体原子经济性合成的新途径
Erika Tassano,Kurt Faber,Mélanie Hall
Erika Tassano
The biocatalytic asymmetric disproportionation of aldehydes catalyzed by horse liver alcohol dehydrogenase (HLADH) was assessed in detail on a series of racemic 2-arylpropanals. Statistical optimization by means of design of experiments (Do...