Catalyst-Free Decarbonylative Trifluoromethylthiolation Enabled by Electron Donor-Acceptor Complex Photoactivation [0.03%]
电子给体-受体复合物光活化促进的无催化剂脱碳酰基三氟甲硫基化反应
Alexander Lipp,Shorouk O Badir,Ryan Dykstra et al.
Alexander Lipp et al.
A catalyst- and additive-free decarbonylative trifluoromethylthiolation of aldehyde feedstocks has been developed. This operationally simple, scalable, and open-to-air transformation is driven by the selective photoexcitation of electron do...
Catalytic Formal Hydroamination of Allylic Alcohols Using Manganese PNP-Pincer Complexes [0.03%]
使用锰PNP-夹心配合物催化肉桂醇的 formal hydroamination反应
Leandro Duarte de Almeida,Florian Bourriquen,Kathrin Junge et al.
Leandro Duarte de Almeida et al.
Several manganese-PNP pincer catalysts for the formal hydroamination of allylic alcohols are presented. The resulting γ-amino alcohols are selectively obtained in high yields applying Mn-1 in a tandem process under mild conditions. ...
Enantioselective Organocatalytic Synthesis of Bicyclic Resorcinols via an Intramolecular Friedel-Crafts-Type 1,4-Addition: Access to Cannabidiol Analogues [0.03%]
通过分子内Friedel-Crafts类型1,4-加成反应不对称有机催化合成双环儿茶酚：通向大麻二酚类似物的方法
Laura A Bryant,Kenneth Shankland,Hannah E Straker et al.
Laura A Bryant et al.
The organocatalytic transformation of resorcinols is extremely rare. In this article, we report a highly enantioselective, organocatalytic intramolecular cyclization of these systems by a Friedel-Crafts-type 1,4-addition using a Jørgensen-...
Asymmetric Allylation Catalyzed by Chiral Phosphoric Acids: Stereoselective Synthesis of Tertiary Alcohols and a Reagent-Based Switch in Stereopreference [0.03%]
手性磷酸催化的不对称烯丙基化反应：仲醇的立体选择性合成及试剂控制的立体专一性的转换
Mattia Lazzarotto,Peter Hartmann,Jakob Pletz et al.
Mattia Lazzarotto et al.
The substrate scope of the asymmetric allylation with zinc organyls catalyzed by 3,3-bis(2,4,6-triisopropylphenyl)-1,1-binaphthyl-2,2-diyl hydrogenphosphate (TRIP) has been extended to non-cyclic ester organozinc reagents and ketones. Terti...
Discovery of New Carbonyl Reductases Using Functional Metagenomics and Applications in Biocatalysis [0.03%]
基于功能元基因组学的新羰基还原酶的发现及其在生物催化中的应用
Sophie A Newgas,Jack W E Jeffries,Thomas S Moody et al.
Sophie A Newgas et al.
Enzyme discovery for use in the manufacture of chemicals, requiring high stereoselectivities, continues to be an important avenue of research. Here, a sequence directed metagenomics approach is described to identify short chain carbonyl red...
Ayan Bhattacharjee,Geraint H M Davies,Borna Saeednia et al.
Ayan Bhattacharjee et al.
Among aromatic compounds, borazarenes represent a significant class of isosteres in which carbon-carbon bonds have been replaced by B-N bonds. Described herein is a summary of the selective reactions that have been developed for known syste...
Practical Synthesis of α-Trifluoromethylated Pyridines Based on Regioselective Cobalt-Catalyzed [2+2+2] Cycloaddition using Trifluoromethylated Diynes with Nitriles [0.03%]
基于区域选择性钴催化[2+2+2]环加成反应的α-三氟甲基吡啶的实际合成方法研究
Tatsuya Kumon,Shigeyuki Yamada,Tomohiro Agou et al.
Tatsuya Kumon et al.
Regioselective cobalt-catalyzed [2+2+2] cycloaddition using fluorine-containing diynes with nitriles was described. Cycloaddition of fluorinated diynes with nitriles under the influence of CoCl2(phen), zinc bromide, and zinc dust in dichlor...
Chemoenzymatic Production of Enantiocomplementary 2-Substituted 3-Hydroxycarboxylic Acids from L-α-Amino Acids [0.03%]
利用L-α-氨基酸制备对映体互补的2-取代-3-羟基羧酸的化学酶法
Mathias Pickl,Roser Marín-Valls,Jesús Joglar et al.
Mathias Pickl et al.
A two-enzyme cascade reaction plus in situ oxidative decarboxylation for the transformation of readily available canonical and non-canonical L-α-amino acids into 2-substituted 3-hydroxy-carboxylic acid derivatives is described. The biocata...
Enantioselective Kinetic Resolution/Desymmetrization of Para-Quinols: A Case Study in Boronic-Acid-Directed Phosphoric Acid Catalysis [0.03%]
对位奎놀的动力学拆分/非对称合成：硼酸控制磷酸催化的一个案例研究
Banruo Huang,Ying He,Mark D Levin et al.
Banruo Huang et al.
A chiral phosphoric acid-catalyzed kinetic resolution and desymmetrization of para-quinols operating via oxa-Michael addition was developed and subsequently subjected to mechanistic study. Good to excellent s-factors/enantioselectivities we...
Radical-Polar Crossover Annulation: A Platform for Accessing Polycyclic Cyclopropanes [0.03%]
极性交叉开环反应构建多环化合物
John A Milligan,Kevin L Burns,Anthony V Le et al.
John A Milligan et al.
Photoredox-mediated radical/polar crossover (RPC) processes provide unique solutions to challenging annulations. Herein, we describe an approach to the cyclopropanation of olefins that are embedded within bicyclic scaffolds. Whereas these s...