Dimsyl Anion Enables Visible-Light-Promoted Charge Transfer in Cross-Coupling Reactions of Aryl Halides [0.03%]
基于狄尔斯-阿尔德反应的阴离子使芳基卤化物交叉偶联反应中可见光促进的电荷转移成为可能
Lei Pan,Maria Victoria Cooke,Amara Spencer et al.
Lei Pan et al.
A methodology is reported for visible-light-promoted synthesis of unsymmetrical chalcogenides enabled by dimsyl anion in the absence of transition-metals or photoredox catalysts. The cross-coupling reaction between aryl halides and diaryl d...
Margit Winkler,Melissa Horvat,Astrid Schiefer et al.
Margit Winkler et al.
Various widely applied compounds contain cyano-groups, and this functional group serves as a chemical handle for a whole range of different reactions. We report a cyanide free chemoenzymatic cascade for nitrile synthesis. The reaction pathw...
Synthesis of Saturated N-Heterocycles via a Catalytic Hydrogenation Cascade [0.03%]
催化氢化级联反应合成饱和氮杂环化合物
Tobias Wagener,Marco Pierau,Arne Heusler et al.
Tobias Wagener et al.
Saturated N-heterocycles are prominent motifs found in various natural products and pharmaceuticals. Despite the increasing interest in this class of compounds, the synthesis of saturated bicyclic azacycles requires tedious multi-step synth...
Combined Photoredox and Carbene Catalysis for the Synthesis of γ-Aryloxy Ketones [0.03%]
光氧化还原与卡宾协同催化γ-芳氧酮化合物的合成
Pengzhi Wang,Keegan P Fitzpatrick,Karl A Scheidt
Pengzhi Wang
N-heterocyclic carbenes (NHCs) have emerged as catalysts for the construction of C-C bonds in the synthesis of substituted ketones under single-electron processes. Despite these recent reports, there still remains a need to increase the uti...
A Mechanistic Probe into 1,2- cis Glycoside Formation Catalyzed by Phenanthroline and Further Expansion of Scope [0.03%]
浅探菲啶催化1,2-顺式糖苷形成的反应机理及底物拓展研究
Jiayi Li,Hien M Nguyen
Jiayi Li
Phenanthroline, a rigid and planar compound with two fused pyridine rings, has been used as a powerful ligand for metals and a binding agent for DNA/RNA. We discovered that phenanthroline could be used as a nucleophilic catalyst to efficien...
Catalyst-Free Decarbonylative Trifluoromethylthiolation Enabled by Electron Donor-Acceptor Complex Photoactivation [0.03%]
电子给体-受体复合物光活化促进的无催化剂脱碳酰基三氟甲硫基化反应
Alexander Lipp,Shorouk O Badir,Ryan Dykstra et al.
Alexander Lipp et al.
A catalyst- and additive-free decarbonylative trifluoromethylthiolation of aldehyde feedstocks has been developed. This operationally simple, scalable, and open-to-air transformation is driven by the selective photoexcitation of electron do...
Catalytic Formal Hydroamination of Allylic Alcohols Using Manganese PNP-Pincer Complexes [0.03%]
使用锰PNP-夹心配合物催化肉桂醇的 formal hydroamination反应
Leandro Duarte de Almeida,Florian Bourriquen,Kathrin Junge et al.
Leandro Duarte de Almeida et al.
Several manganese-PNP pincer catalysts for the formal hydroamination of allylic alcohols are presented. The resulting γ-amino alcohols are selectively obtained in high yields applying Mn-1 in a tandem process under mild conditions. ...
Enantioselective Organocatalytic Synthesis of Bicyclic Resorcinols via an Intramolecular Friedel-Crafts-Type 1,4-Addition: Access to Cannabidiol Analogues [0.03%]
通过分子内Friedel-Crafts类型1,4-加成反应不对称有机催化合成双环儿茶酚：通向大麻二酚类似物的方法
Laura A Bryant,Kenneth Shankland,Hannah E Straker et al.
Laura A Bryant et al.
The organocatalytic transformation of resorcinols is extremely rare. In this article, we report a highly enantioselective, organocatalytic intramolecular cyclization of these systems by a Friedel-Crafts-type 1,4-addition using a Jørgensen-...
Asymmetric Allylation Catalyzed by Chiral Phosphoric Acids: Stereoselective Synthesis of Tertiary Alcohols and a Reagent-Based Switch in Stereopreference [0.03%]
手性磷酸催化的不对称烯丙基化反应：仲醇的立体选择性合成及试剂控制的立体专一性的转换
Mattia Lazzarotto,Peter Hartmann,Jakob Pletz et al.
Mattia Lazzarotto et al.
The substrate scope of the asymmetric allylation with zinc organyls catalyzed by 3,3-bis(2,4,6-triisopropylphenyl)-1,1-binaphthyl-2,2-diyl hydrogenphosphate (TRIP) has been extended to non-cyclic ester organozinc reagents and ketones. Terti...
Discovery of New Carbonyl Reductases Using Functional Metagenomics and Applications in Biocatalysis [0.03%]
基于功能元基因组学的新羰基还原酶的发现及其在生物催化中的应用
Sophie A Newgas,Jack W E Jeffries,Thomas S Moody et al.
Sophie A Newgas et al.
Enzyme discovery for use in the manufacture of chemicals, requiring high stereoselectivities, continues to be an important avenue of research. Here, a sequence directed metagenomics approach is described to identify short chain carbonyl red...