Aerobic Oxidative Coupling of o-Xylene: Discovery of 2-Fluoropyridine as a Ligand to Support Selective Pd-Catalyzed C-H Functionalization [0.03%]
邻甲基苯乙烯的有氧偶联：发现氟代吡啶是支持钯催化C-H功能化的配体
Yusuke Izawa,Shannon S Stahl
Yusuke Izawa
An improved method for direct oxidative coupling of o-xylene could provide streamlined access to an important monomer used in polyimide resins. The use of 2-fluoropyridine as a ligand has been found to enable unprecedented levels of chemo- ...
Pd/P(t-Bu)(3)-Catalyzed Suzuki Cross-Couplings in the Presence of Water [0.03%]
水存在下的Suzuki交叉偶联反应催化剂Pd/P(t-Bu)_3
Sha Lou,Gregory C Fu
Sha Lou
Pd(2)(dba)(3)/[HP(t-Bu)(3)]BF(4)/KF•2H(2)O serves as a mild, robust, and user-friendly method for the efficient Suzuki cross-coupling of a diverse array of aryl and heteroaryl halides with aryl- and heteroarylboronic acids.
Iridium Catalyzed Hydro-hydroxyalkylation of Butadiene: Carbonyl Crotylation [0.03%]
用于丁二烯的铱催化氢-羟基烷基化反应：羰基crotylation反应
Jason R Zbieg,Takeo Fukuzumi,Michael J Krische
Jason R Zbieg
Exposure of alcohols 1a-1i to butadiene in the presence of a cyclometallated iridium catalyzed derived from allyl acetate, 4-methoxy-3-nitrobenzoic acid and BIPHEP (2,2'-bis(diphenylphosphino)biphenyl) results in hydrogen transfer to genera...
Salicylaldimine Ruthenium Alkylidene Complexes: Metathesis Catalysts Tuned for Protic Solvents [0.03%]
水性溶剂中Metathesis催化剂的调控：邻苯二甲酰亚胺钌炔基配合物的例子
Joseph B Binder,Ilia A Guzei,Ronald T Raines
Joseph B Binder
Tuning the electronic and steric environment of olefin metathesis catalysts with specialized ligands can adapt them to broader applications, including metathesis in aqueous solvents. Bidentate salicylaldimine ligands are known to stabilize ...
Direct Copper-Free Domino Conjugate Addition-Cycloallylation using Organozinc Reagents [0.03%]
无需铜的有机锌试剂连续加成-环丙基化反应
Venukrishnan Komanduri,Fernando Pedraza,Michael J Krische
Venukrishnan Komanduri
The Direct Approach: Enones possessing appendant allylic carbonates react directly with diorganozinc reagents in the presence of zinc diiodide [ZnI(2)] to provide 5- and 6-membered ring products of tandem or domino conjugate addition-cycloa...
Asymmetric Reduction of Activated Alkenes by Pentaerythritol Tetranitrate Reductase: Specificity and Control of Stereochemical Outcome by Reaction Optimisation [0.03%]
用硝酸异山梨酯还原酶不对称催化活化烯烃的还原：反应优化调控立体选择性
Anna Fryszkowska,Helen Toogood,Michiyo Sakuma et al.
Anna Fryszkowska et al.
We show that pentaerythritol tetranitrate reductase (PETNR), a member of the 'ene' reductase old yellow enzyme family, catalyses the asymmetric reduction of a variety of industrially relevant activated alpha,beta-unsaturated alkenes includi...
Structure-Based Insight into the Asymmetric Bioreduction of the C=C Double Bond of alpha,beta-Unsaturated Nitroalkenes by Pentaerythritol Tetranitrate Reductase [0.03%]
基于结构的戊四醇四硝酸酯还原酶不对称生物还原α,β-不饱和硝基烯烃碳碳双键的见解
Helen S Toogood,Anna Fryszkowska,Victoria Hare et al.
Helen S Toogood et al.
Biocatalytic reduction of alpha- or beta-alkyl-beta-arylnitroalkenes provides a convenient and efficient method to prepare chiral substituted nitroalkanes. Pentaerythritol tetranitrate reductase (PETN reductase) from Enterobacter cloacae st...
An Enantioselective Synthesis of the ABD Tricycle for (-)-Phomactin A Featuring Rawal's Asymmetric Diels-Alder Cycloaddition [0.03%]
以Rawal不对称Diels-Alderase环加成为核心的(-)-PhomactinA的ABD三环的绝对立体选择性合成
Ling-Feng You,Richard P Hsung,Aaron A Bedermann et al.
Ling-Feng You et al.
An enantioselective synthesis of the ABD-ring of (-)-phomactin A is described here. The sequence features Rawal's asymmetric Diels-Alder cycloaddition. The overall length is significantly reduced from our previous attempt.
Chemoenzymatic Syntheses of Tumor-Associated Carbohydrate Antigen Globo-H and Stage-Specific Embryonic Antigen 4 [0.03%]
肿瘤相关碳水化合物抗原Globo-H和胚胎特异性阶段抗原4的化学生物合成
Zhen Wang,Michel Gilbert,Hironobu Eguchi et al.
Zhen Wang et al.
Gangliosides have attracted much attention due to their important biological properties. Herein, we report the first chemoenzymatic syntheses of two globo series of ganglioside oligosaccharides, Globo-H 1 and stage-specific embryonic antige...
Synthesis of N-Aryl-2-allyl Pyrrolidines via Palladium-catalyzed Carboamination Reactions of γ-(N-Arylamino)alkenes with Vinyl Bromides [0.03%]
γ-（N-芳基氨基）烯烃与乙烯基溴化物的钯催化碳氨化反应合成N-芳基-2-烯丙基吡咯烷类化合物
Joshua E Ney,Michael B Hay,Qifei Yang et al.
Joshua E Ney et al.
A palladium-catalyzed carboamination reaction of γ-N-arylamino alkenes with vinyl bromides that affords N-aryl-2-allyl pyrrolidines is described. These reactions proceed with high diastereoselectivity for the formation of trans-2,3- and ci...