Asymmetric Reduction of Activated Alkenes by Pentaerythritol Tetranitrate Reductase: Specificity and Control of Stereochemical Outcome by Reaction Optimisation [0.03%]
用硝酸异山梨酯还原酶不对称催化活化烯烃的还原：反应优化调控立体选择性
Anna Fryszkowska,Helen Toogood,Michiyo Sakuma et al.
Anna Fryszkowska et al.
We show that pentaerythritol tetranitrate reductase (PETNR), a member of the 'ene' reductase old yellow enzyme family, catalyses the asymmetric reduction of a variety of industrially relevant activated alpha,beta-unsaturated alkenes includi...
Structure-Based Insight into the Asymmetric Bioreduction of the C=C Double Bond of alpha,beta-Unsaturated Nitroalkenes by Pentaerythritol Tetranitrate Reductase [0.03%]
基于结构的戊四醇四硝酸酯还原酶不对称生物还原α,β-不饱和硝基烯烃碳碳双键的见解
Helen S Toogood,Anna Fryszkowska,Victoria Hare et al.
Helen S Toogood et al.
Biocatalytic reduction of alpha- or beta-alkyl-beta-arylnitroalkenes provides a convenient and efficient method to prepare chiral substituted nitroalkanes. Pentaerythritol tetranitrate reductase (PETN reductase) from Enterobacter cloacae st...
An Enantioselective Synthesis of the ABD Tricycle for (-)-Phomactin A Featuring Rawal's Asymmetric Diels-Alder Cycloaddition [0.03%]
以Rawal不对称Diels-Alderase环加成为核心的(-)-PhomactinA的ABD三环的绝对立体选择性合成
Ling-Feng You,Richard P Hsung,Aaron A Bedermann et al.
Ling-Feng You et al.
An enantioselective synthesis of the ABD-ring of (-)-phomactin A is described here. The sequence features Rawal's asymmetric Diels-Alder cycloaddition. The overall length is significantly reduced from our previous attempt.
Chemoenzymatic Syntheses of Tumor-Associated Carbohydrate Antigen Globo-H and Stage-Specific Embryonic Antigen 4 [0.03%]
肿瘤相关碳水化合物抗原Globo-H和胚胎特异性阶段抗原4的化学生物合成
Zhen Wang,Michel Gilbert,Hironobu Eguchi et al.
Zhen Wang et al.
Gangliosides have attracted much attention due to their important biological properties. Herein, we report the first chemoenzymatic syntheses of two globo series of ganglioside oligosaccharides, Globo-H 1 and stage-specific embryonic antige...
Synthesis of N-Aryl-2-allyl Pyrrolidines via Palladium-catalyzed Carboamination Reactions of γ-(N-Arylamino)alkenes with Vinyl Bromides [0.03%]
γ-（N-芳基氨基）烯烃与乙烯基溴化物的钯催化碳氨化反应合成N-芳基-2-烯丙基吡咯烷类化合物
Joshua E Ney,Michael B Hay,Qifei Yang et al.
Joshua E Ney et al.
A palladium-catalyzed carboamination reaction of γ-N-arylamino alkenes with vinyl bromides that affords N-aryl-2-allyl pyrrolidines is described. These reactions proceed with high diastereoselectivity for the formation of trans-2,3- and ci...
Air/Water-Stable Tridentate NHC-Pd Complex; Catalytic C-H Activation of Hydrocarbons via H/D Exchange Process in D(2)O [0.03%]
稳定的三齿NHC-Pd配合物; 可在D₂O中通过H/D交换过程活化烷烃C-H键催化剂作用下实现
Joo Ho Lee,Kyung Soo Yoo,Chan Pil Park et al.
Joo Ho Lee et al.
While developing novel catalysts for carbon-carbon or carbon-heteroatom coupling (N, O, or F), we were able to introduce tridentate NHC-amidate-alkoxide palladium(II) complexes. In aqueous solution, these NHC-Pd(II) complexes showed high ab...
Homobenzotetramisole-Catalyzed Kinetic Resolution of alpha-Aryl-, alpha-Aryloxy-, and alpha-Arylthioalkanoic Acids [0.03%]
联苯四氨叶立德催化的α-芳基、α-芳氧和α-芳硫代烷酸的动力学拆分
Xing Yang,Vladimir B Birman
Xing Yang
Effective kinetic resolution of alpha-aryl-, alpha-aryloxy-, and alpha-arylthioalkanoic acids has been achieved via in situ generation of their symmetrical anhydrides and enantioselective alcoholysis in the presence of homobenzotetramisole ...
Synthesis of Fluorenes via the Palladium-Catalyzed 5-Exo-dig Annulation of o-Alkynyl Biaryls [0.03%]
钯催化o-烷基联芳基的5-exo环化反应合成荧蒽类化合物
Natalia Chernyak,Vladimir Gevorgyan
Natalia Chernyak
The direct Pd-catalyzed intramolecular rapidly with electron-deficient benzene ring, which, in hydroarylation of o-alkynyl biaryls proceeded in highly combination with a substantial isotope effect observed, stereoselective manner producing ...
Comparison of the Relative Reactivities of the Triisopropylsilyl Group With Two Fluorous Analogs [0.03%]
三异丙基硅基与两种含氟类似物相对反应性的比较研究
Amador Garcia Sancho,Xiao Wang,Bin Sui et al.
Amador Garcia Sancho et al.
The relative stabilities of two fluorous analogs, diisopropyl(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)silyl and diisopropyl-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadeca-fluoroundecyl)silyl [C(8)F(17)(CH(2))(n)Si(i-Pr)...
Copper(II)-Catalyzed Aminooxygenation and Carboamination of N-Aryl-2-allylanilines [0.03%]
催化N-芳基-2-烯丙基苯胺的氨氧化和碳氢氨化反应
Eric S Sherman,Sherry R Chemler
Eric S Sherman
The scope of the intramolecular copper(II)-catalyzed carboamination and aminooxygenation reactions of olefins has been extended to include N-aryl-2-allylanilines. These substrates exhibit divergent reactivity under catalytic vs. stoichiomet...