Studies Toward the Synthesis of (-)-Zampanolide: Preparation of the Macrocyclic Core [0.03%]
(-)-Zampanolide合成研究：宏环核心结构的构建
Dawn M Troast,Jiayi Yuan,John A Porco Jr
Dawn M Troast
Studies towards the synthesis of the macrocyclic core of (-)-zampanolide are reported. The synthetic approach features a one-pot reduction/vinylogous aldol reaction for construction of the C15-C20 fragment, an intramolecular silyl-modified ...
An Improved Synthesis of BrettPhos and RockPhos-Type Biarylphosphine Ligands [0.03%]
改进的BrettPhos和RockPhos型联芳基膦配体合成方法
Naoyuki Hoshiya,Stephen L Buchwald
Naoyuki Hoshiya
Improved processes for the preparation of biphenyl-based phosphine ligands t-BuBrettPhos, RockPhos, and BrettPhos are presented. The new methods, featuring the use of Grignard reagents and catalytic amounts of copper, are superior to the pr...
Exploiting Acyl and Enol Azolium Intermediates via NHeterocyclic Carbene Catalyzed Reactions of Alpha-Reducible Aldehydes [0.03%]
通过氮杂环卡宾催化可还原醛的反应利用酰基和烯醇重氮𬭩中间体
Harit U Vora,Philip Wheeler,Tomislav Rovis
Harit U Vora
N-heterocyclic carbenes are well known for their role in catalyzing benzoin and Stetter reactions: the generation of acyl anion equivalents from simple aldehydes to react with a variety of electrophiles. However, when an aldehyde bearing a ...
Selective Autooxidation of Ethanol over Titania-Supported Molybdenum Oxide Catalysts: Structure and Reactivity [0.03%]
负载钼氧化物的选择性乙醇氧化及其结构和反应性能关系研究
Carlos Caro,K Thirunavukkarasu,M Anilkumar et al.
Carlos Caro et al.
We study the selective catalytic oxidation of ethanol with air as a sustainable alternative route to acetaldehyde. The reaction is catalysed by molybdenum oxide supported on titania, in a flow reactor under ambient pressure. High selectivit...
Tina Gerhards,Ursula Mackfeld,Marco Bocola et al.
Tina Gerhards et al.
The asymmetric mixed carboligation of aldehydes with thiamine diphosphate (ThDP)-dependent enzymes is an excellent example where activity as well as changes in chemo- and stereoselectivity can be followed sensitively. To elucidate the influ...
Zea Strassberger,Maurice Mooijman,Eelco Ruijter et al.
Zea Strassberger et al.
We combine multicomponent reactions, catalytic performance studies and predictive modelling to find transfer hydrogenation catalysts. An initial set of 18 ruthenium-carbene complexes were synthesized and screened in the transfer hydrogenati...
Synthesis of α-Arylphosphonates Using Copper-Catalyzed α-Arylation and Deacylative α-Arylation of β-Ketophosphonates [0.03%]
铜催化β-酮亚磷酸酯的α-芳基化及脱酰基α-芳基化合成α-芳基亚磷酸酯
Laxmidhar Rout,Sridhar Regati,Cong-Gui Zhao
Laxmidhar Rout
Efficient methods for the direct arylation and deacylative arylation of β-ketophosphonates with iodoarenes in presence of a copper(I) or a copper(II) salt as the catalysts were developed. The corresponding α-arylphosphonates were obtained...
Iridium-Catalyzed Allylic Amination Route to α-Aminoboronates: Illustration of the Decisive Role of Boron Substituents [0.03%]
铱催化α-氨基硼酸酯的烯丙基胺化反应：硼取代基决定性的角色分析
Sabrina Touchet,François Carreaux,Gary A Molander et al.
Sabrina Touchet et al.
The development of a new route to α-aminoboronates using an iridium-catalyzed allylic amination on boronated substrates is described. Unlike the boronate group, the trifluoroborato substituent was found to govern the regioselectivity exclu...
The Efficient and Enantiospecific Total Synthesis of Cyclopenta[b]phenanthrenes Structurally-related to Neurosteroids [0.03%]
与神经甾体结构相关的环戊并[б]菲烷的高效对映选择性全合成
Mingxing Qian,Douglas F Covey
Mingxing Qian
We report an efficient synthesis of cyclopenta[b]phenanthrenes functionalized at C-3 and C-8 from an optically pure Hajos-Parrish ketone. The key step is a neutral alumina catalyzed Michael addition of a Hajos-Parrish ketone derivative (4) ...
Organocatalytic High Enantioselective Synthesis of β-Formyl-α-hydroxyphosphonates [0.03%]
高对映选择性有机催化合成β-甲醛-α-羟基磷onic酸酯类化合物
Sandun Perera,Vijaya Kumar Naganaboina,Long Wang et al.
Sandun Perera et al.
The cross aldol reaction between enolizable aldehydes and α-ketophosphonates was achieved for the first time by using 9-amino-9-deoxy-epi-quinine as the catalyst. β-Formyl-α-hydroxyphosphonates were obtained in high to excellent enantios...