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Studies Toward the Synthesis of (-)-Zampanolide: Preparation of the Macrocyclic Core

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Studies towards the synthesis of the macrocyclic core of (-)-zampanolide are reported. The synthetic approach features a one-pot reduction/vinylogous aldol reaction for construction of the C15-C20 fragment, an intramolecular silyl-modified Sakurai (ISMS) react... ...