Nitrile as Activating Group in the Asymmetric Bioreduction of β-Cyanoacrylic Acids Catalyzed by Ene-Reductases [0.03%]
天冬氨酸衍生物催化下β-氰基丙酸的不对称生物还原反应中硝基的活化作用研究
Christoph K Winkler,Dorina Clay,Nikolaus G Turrini et al.
Christoph K Winkler et al.
Asymmetric bioreduction of an (E)-β-cyano-2,4-dienoic acid derivative by ene-reductases allowed a shortened access to a precursor of pregabalin [(S)-3-(aminomethyl)-5-methylhexanoic acid] possessing the desired configuration in up to 94% c...
Asymmetric Synthesis of Substituted Thiolanes through Domino Thia-Michael-Henry Dynamic Covalent Systemic Resolution using Lipase Catalysis [0.03%]
酶催化连续的动态共价系统拆分合成不对称硫代环烷烃
Yan Zhang,Pornrapee Vongvilai,Morakot Sakulsombat et al.
Yan Zhang et al.
Dynamic systems based on consecutive thia-Michael and Henry reactions were generated and transformed using lipase-catalyzed asymmetric transformation. Substituted thiolane structures with three contiguous stereocenters were resolved in the ...
A Convenient Synthetic Protocol to 1,2-Bis(dialkylphosphino)ethanes [0.03%]
用于合成1,2-双(烷基磷烷亚甲基)化合物的简便方法
Laurence R Doyle,Alex Heath,Choon Heng Low et al.
Laurence R Doyle et al.
1,2-Bis(dialkylphosphino)ethanes are readily prepared from the parent phosphine oxides, via a novel sodium aluminium hydride/sodium hydride reduction protocol of intermediate chlorophosphonium chlorides. This approach is amenable to multi-g...
Enzymatic Redox Cascade for One-Pot Synthesis of Uridine 5'-Diphosphate Xylose from Uridine 5'-Diphosphate Glucose [0.03%]
基于尿苷二磷酸葡萄糖的一锅法合成尿苷二磷酸木糖的酶促氧化还原级联反应
Thomas Eixelsberger,Bernd Nidetzky
Thomas Eixelsberger
Synthetic ways towards uridine 5'-diphosphate (UDP)-xylose are scarce and not well established, although this compound plays an important role in the glycobiology of various organisms and cell types. We show here how UDP-glucose 6-dehydroge...
Dissecting Anion Effects in Gold(I)-Catalyzed Intermolecular Cycloadditions [0.03%]
金(I)催化介观环加成中阴离子效应的剖析
Anna Homs,Carla Obradors,David Lebœuf et al.
Anna Homs et al.
From a series of gold complexes of the type [t-BuXPhosAu(MeCN)]X (X=anion), the best results in intermolecular gold(I)-catalyzed reactions are obtained with the complex with the bulky and soft anion BAr4F- [BAr4F-=3,5-bis(trifluoromethyl)ph...
Reversed-Polarity Synthesis of Diaryl Ketones through Palladium-Catalyzed Direct Arylation of 2-Aryl-1,3-dithianes [0.03%]
钯催化2-芳基-1,3-二硫杂环
Baris Yucel,Patrick J Walsh
Baris Yucel
An umpolung approach to the synthesis of diaryl ketones has been developed based on in situ generation of acyl anion equivalents and their catalytic arylation. This method entails the base promoted palladium catalyzed direct C-H arylation o...
Intermolecular [3+2] Annulation of Cyclopropylanilines with Alkynes, Enynes, and Diynes via Visible Light Photocatalysis [0.03%]
可见光催化环丙烷胺与炔烃、烯炔和二炔的分子间[3+2]环化反应
Theresa H Nguyen,Scott A Morris,Nan Zheng
Theresa H Nguyen
One-step synthesis of carbocycles substituted with amines from simple starting materials remains rare. We recently developed intermolecular [3+2] annulation of cyclopropylanilines with alkenes and alkynes that enable this one-step synthesis...
Mild and General Access to Diverse 1 H-Benzotriazoles via Diboron-Mediated N-OH Deoxygenation and Palladium-Catalyzed C-C and C-N Bond Formation [0.03%]
通过二硼介导的N-O氢脱氧和钯催化C-C和C-N键形成合成多样化的1H-苯并三唑类化合物
Venkateshwarlu Gurram,Hari K Akula,Ramesh Garlapati et al.
Venkateshwarlu Gurram et al.
Benzotriazoles are a highly important class of compounds with broad-ranging applications in such diverse areas as medicinal chemistry, as auxiliaries in organic synthesis, in metallurgical applications, in aircraft deicing and brake fluids,...
Palladium-Catalyzed Direct α-Aryation of Benzyl Thioethers with Aryl Bromides [0.03%]
钯催化下苯硫醚的直接α-芳基化反应
Gustavo Frensch,Nusrah Hussain,Francisco A Marques et al.
Gustavo Frensch et al.
The arylation of sp3-hybridized C-H's bonds is a powerful strategy to build molecular complexity and diversity. A novel and efficient palladium-catalyzed direct sp3 C-H arylation of aryl and alkyl benzyl thioether derivatives with aryl brom...
Phosphine-Catalyzed [3+2] and [4+3]Annulation Reactions of C,N-Cyclic Azomethine Imines with Allenoates [0.03%]
磷催化的C,N-环状重氮甲基亚胺与丙二烯酸酯的[3+2]和[4+3]环化反应
Chengfeng Jing,Risong Na,Bo Wang et al.
Chengfeng Jing et al.
Phosphine-catalyzed [3+2] and [4+3]annulation reactions of C,N-cyclic azomethine imines with allenoates have been developed to give a variety of pharmaceutically attractive tetrahydroisoquinoline derivatives in moderate to excellent yields....