Reversed-Polarity Synthesis of Diaryl Ketones through Palladium-Catalyzed Direct Arylation of 2-Aryl-1,3-dithianes [0.03%]
钯催化2-芳基-1,3-二硫杂环𬭩盐的直接芳基化： diaryl酮的反极性合成
Baris Yucel,Patrick J Walsh
Baris Yucel
An umpolung approach to the synthesis of diaryl ketones has been developed based on in situ generation of acyl anion equivalents and their catalytic arylation. This method entails the base promoted palladium catalyzed direct C-H arylation o...
Intermolecular [3+2] Annulation of Cyclopropylanilines with Alkynes, Enynes, and Diynes via Visible Light Photocatalysis [0.03%]
可见光催化环丙烷胺与炔烃、烯炔和二炔的分子间[3+2]环化反应
Theresa H Nguyen,Scott A Morris,Nan Zheng
Theresa H Nguyen
One-step synthesis of carbocycles substituted with amines from simple starting materials remains rare. We recently developed intermolecular [3+2] annulation of cyclopropylanilines with alkenes and alkynes that enable this one-step synthesis...
Mild and General Access to Diverse 1 H-Benzotriazoles via Diboron-Mediated N-OH Deoxygenation and Palladium-Catalyzed C-C and C-N Bond Formation [0.03%]
通过二硼介导的N-O氢脱氧和钯催化C-C和C-N键形成合成多样化的1H-苯并三唑类化合物
Venkateshwarlu Gurram,Hari K Akula,Ramesh Garlapati et al.
Venkateshwarlu Gurram et al.
Benzotriazoles are a highly important class of compounds with broad-ranging applications in such diverse areas as medicinal chemistry, as auxiliaries in organic synthesis, in metallurgical applications, in aircraft deicing and brake fluids,...
Palladium-Catalyzed Direct α-Aryation of Benzyl Thioethers with Aryl Bromides [0.03%]
钯催化下苯硫醚的直接α-芳基化反应
Gustavo Frensch,Nusrah Hussain,Francisco A Marques et al.
Gustavo Frensch et al.
The arylation of sp3-hybridized C-H's bonds is a powerful strategy to build molecular complexity and diversity. A novel and efficient palladium-catalyzed direct sp3 C-H arylation of aryl and alkyl benzyl thioether derivatives with aryl brom...
Phosphine-Catalyzed [3+2] and [4+3]Annulation Reactions of C,N-Cyclic Azomethine Imines with Allenoates [0.03%]
磷催化的C,N-环状重氮甲基亚胺与丙二烯酸酯的[3+2]和[4+3]环化反应
Chengfeng Jing,Risong Na,Bo Wang et al.
Chengfeng Jing et al.
Phosphine-catalyzed [3+2] and [4+3]annulation reactions of C,N-cyclic azomethine imines with allenoates have been developed to give a variety of pharmaceutically attractive tetrahydroisoquinoline derivatives in moderate to excellent yields....
Metal-Free Preparation of Cycloalkyl Aryl Sulfides via Di-tert-butyl Peroxide-Promoted Oxidative C(sp3)[BOND]H Bond Thiolation of Cycloalkanes [0.03%]
通过二叔丁基过氧化物促进的氧化脱氢硫化茋𬭩盐制备环烷芳基硫醚
Jincan Zhao,Hong Fang,Jianlin Han et al.
Jincan Zhao et al.
A concise thiolation of C(sp3)-H bond of cycloalkanes with diaryl disulfides in the presence of oxidant of di-tert-butylperoxide (DTBP) has been developed. This reaction without using any of metal catalyst, tolerates varieties of disulfides...
6-Azabicyclo[3.2.1]octanes Via Copper-Catalyzed Enantioselective Alkene Carboamination [0.03%]
铜催化内消旋烯烃亚胺的环化反应生成6-氮杂双环[3.2.1]辛烷类化合物
Barbara J Casavant,Azade S Hosseini,Sherry R Chemler
Barbara J Casavant
Bridged bicyclic rings containing nitrogen heterocycles are important motifs in bioactive small organic molecules. An enantioselective copper-catalyzed alkene carboamination reaction that creates bridged heterocycles is reported herein. Two...
Catalytic Isonitrile Insertions and Condensations Initiated by RNC-X Complexation [0.03%]
由RNC-X配位引发的异氰化合物催化插入和缩合反应
Suravi Chakrabarty,Shruti Choudhary,Arpit Doshi et al.
Suravi Chakrabarty et al.
Isonitriles are delicately poised chemical entities capable of being coaxed to react as nucleophiles or electrophiles. Directing this tunable reactivity with metal and non-metal catalysts provides rapid access to a large array of complex ni...
Regioselective Benzylation of 2-Deoxy-2-Aminosugars Using Crown Ethers: Application to a Shortened Synthesis of Hyaluronic Acid Oligomers [0.03%]
冠醚用于2-脱氧-2-氨基糖区域选择性苄基化：透明质酸寡聚物简明合成中的应用
Chinmoy Mukherjee,Lin Liu,Nicola L B Pohl
Chinmoy Mukherjee
The combination of benzyl bromide, sodium hydroxide and 15-crown-5 in tetrahydrofuran is shown to be an efficient method for installing benzyl groups at both the 4- and 6-positions regioselectively directly from peracetylated N-trichloroace...
Transition-Metal-Free ipso-Functionalization of Arylboronic Acids and Derivatives [0.03%]
无过渡金属参与的芳基硼酸和衍生物的ipso官能化反应
Chen Zhu,John R Falck
Chen Zhu
Arylboronic acids and their derivatives have been widely exploited as important synthetic precursors in organic synthesis, materials science, and pharmaceutical development. In addition to numerous applications in transition-metal-mediated ...