N-BAR and F-BAR proteins-endophilin-A3 and PSTPIP1-control clathrin-independent endocytosis of L1CAM [0.03%]
N-末端和F-末端蛋白（如endophilin-A3和PSTPIP1）控制L1CAM的钳形独立内吞作用
Camille Lemaigre,Apolline Ceuppens,Cesar Augusto Valades-Cruz et al.
Camille Lemaigre et al.
Recent advances in the field demonstrate the high diversity and complexity of endocytic pathways. In the current study, we focus on the endocytosis of L1CAM. This glycoprotein plays a major role in the development of the nervous system, and...
Cysteinyl leukotriene receptor 1 is a potent regulator of the endosomal-lysosomal system in the ARPE-19 retinal pigment epithelial cell line [0.03%]
半胱氨酰白三烯受体1通过调节内吞体溶酶体系统在ARPE-19色素上皮细胞系中发挥作用
Andreas Koller,Susanne Maria Brunner,Julia Preishuber-Pflügl et al.
Andreas Koller et al.
The endosomal-lysosomal system is central for cell homeostasis and comprises the functions and dynamics of particular organelles including endosomes, lysosomes and autophagosomes. In previous studies, we found that the cysteinyl leukotriene...
Golgi screen identifies the RhoGEF Solo as a novel regulator of RhoB and endocytic transport [0.03%]
高尔基体文库筛选发现RhoGEF Solo 是RhoB和内吞运输的新调节因子
Cristiana Lungu,Florian Meyer,Marcel Hörning et al.
Cristiana Lungu et al.
The control of intracellular membrane trafficking by Rho GTPases is central to cellular homeostasis. How specific guanine nucleotide exchange factors and GTPase-activating proteins locally balance GTPase activation in this process is nevert...
Metabolic depletion of sphingolipids inhibits agonist-induced endocytosis of the serotonin1A receptor [0.03%]
神经酰胺类脂质的代谢耗竭抑制了血清素1A受体的激动剂诱导的胞吞作用
Abhishek Kumar,Parijat Sarkar,Amitabha Chattopadhyay
Abhishek Kumar
G protein-coupled receptors (GPCRs) are vital cellular signaling machinery and currently represent ~40% drug targets. Endocytosis of GPCRs is an important process that allows stringent spatiotemporal control over receptor population on the ...
Inhibition of cholesterol transport impairs Cav-1 trafficking and small extracellular vesicles secretion, promoting amphisome formation in melanoma cells [0.03%]
胆固醇转运的抑制影响Cav-1的转运及小胞外囊泡的分泌，促进黑色素瘤细胞中的两面神体形成
Daniela Peruzzu,Zaira Boussadia,Federica Fratini et al.
Daniela Peruzzu et al.
Caveolin-1 (Cav-1) is a fundamental constituent of caveolae, whose functionality and structure are strictly dependent on cholesterol. In this work the U18666A inhibitor was used to study the role of cholesterol transport in the endosomal de...
Henipaviruses and lyssaviruses target nucleolar treacle protein and regulate ribosomal RNA synthesis [0.03%]
亨尼帕病毒和裂谷热病毒靶向核仁treacle蛋白并调节核糖体RNA合成
Stephen M Rawlinson,Tianyue Zhao,Katie Ardipradja et al.
Stephen M Rawlinson et al.
The nucleolus is a common target of viruses and viral proteins, but for many viruses the functional outcomes and significance of this targeting remains unresolved. Recently, the first intranucleolar function of a protein of a cytoplasmicall...
Acute COG complex inactivation unveiled its immediate impact on Golgi and illuminated the nature of intra-Golgi recycling vesicles [0.03%]
急性COG复合物失活揭示了其对高尔基体的即时影响并阐明了高尔基体内循环囊泡的本质
Farhana Taher Sumya,Irina D Pokrovskaya,Zinia D&#x;Souza et al.
Farhana Taher Sumya et al.
Conserved Oligomeric Golgi (COG) complex controls Golgi trafficking and glycosylation, but the precise COG mechanism is unknown. The auxin-inducible acute degradation system was employed to investigate initial defects resulting from COG dys...
Lauren Kustigian,Xue Gong,Wei Gai et al.
Lauren Kustigian et al.
Membrane-enclosed transport carriers sort biological molecules between stations in the cell in a dynamic process that is fundamental to the physiology of eukaryotic organisms. While much is known about the formation and release of carriers ...
AP2S1 regulates APP degradation through late endosome-lysosome fusion in cells and APP/PS1 mice [0.03%]
AP2S1通过细胞和APP/PS1小鼠的晚期内体-溶酶体融合调节APP降解
Qi-Xin Wen,Biao Luo,Xiao-Yong Xie et al.
Qi-Xin Wen et al.
AP2S1 is the sigma 2 subunit of adaptor protein 2 (AP2) that is essential for endocytosis. In this study, we investigated the potential role of AP2S1 in intracellular processing of amyloid precursor protein (APP), which contributes to the p...
Cab45 deficiency leads to the mistargeting of progranulin and prosaposin and aberrant lysosomal positioning [0.03%]
Cab45的缺乏导致前胞质素和前脑形精子定位错误以及溶酶体位置异常
Mai Ly Tran,Johanna Tüshaus,Yeongho Kim et al.
Mai Ly Tran et al.
The trans-Golgi Network (TGN) sorts molecular "addresses" and sends newly synthesized proteins to their destination via vesicular transport carriers. Despite the functional significance of packaging processes at the TGN, the sorting of solu...