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AP2S1 regulates APP degradation through late endosome-lysosome fusion in cells and APP/PS1 mice

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AP2S1 is the sigma 2 subunit of adaptor protein 2 (AP2) that is essential for endocytosis. In this study, we investigated the potential role of AP2S1 in intracellular processing of amyloid precursor protein (APP), which contributes to the pathogenesis of Alzhe... ...