Lauren Kustigian,Xue Gong,Wei Gai et al.
Lauren Kustigian et al.
Membrane-enclosed transport carriers sort biological molecules between stations in the cell in a dynamic process that is fundamental to the physiology of eukaryotic organisms. While much is known about the formation and release of carriers ...
AP2S1 regulates APP degradation through late endosome-lysosome fusion in cells and APP/PS1 mice [0.03%]
AP2S1通过细胞和APP/PS1小鼠的晚期内体-溶酶体融合调节APP降解
Qi-Xin Wen,Biao Luo,Xiao-Yong Xie et al.
Qi-Xin Wen et al.
AP2S1 is the sigma 2 subunit of adaptor protein 2 (AP2) that is essential for endocytosis. In this study, we investigated the potential role of AP2S1 in intracellular processing of amyloid precursor protein (APP), which contributes to the p...
Cab45 deficiency leads to the mistargeting of progranulin and prosaposin and aberrant lysosomal positioning [0.03%]
Cab45的缺乏导致前胞质素和前脑形精子定位错误以及溶酶体位置异常
Mai Ly Tran,Johanna Tüshaus,Yeongho Kim et al.
Mai Ly Tran et al.
The trans-Golgi Network (TGN) sorts molecular "addresses" and sends newly synthesized proteins to their destination via vesicular transport carriers. Despite the functional significance of packaging processes at the TGN, the sorting of solu...
Developmental program-independent secretory granule degradation in larval salivary gland cells of Drosophila [0.03%]
果蝇幼虫唾腺细胞中发育程序非依赖性分泌颗粒降解
Tamás Csizmadia,Anna Dósa,Erika Farkas et al.
Tamás Csizmadia et al.
Both constitutive and regulated secretion require cell organelles that are able to store and release the secretory cargo. During development, the larval salivary gland of Drosophila initially produces high amount of glue-containing small im...
Multiplexed cellular profiling identifies an organoselenium compound as an inhibitor of CRM1-mediated nuclear export [0.03%]
多路复用的细胞分析确定了一种器官硒化合物是CRM1介导的核输出的抑制剂
Lucia Jimenez,Victor Mayoral-Varo,Carlos Amenábar et al.
Lucia Jimenez et al.
Chromosomal region maintenance 1 (CRM1 also known as Xpo1 and exportin-1) is the receptor for the nuclear export controlling the intracellular localization and function of many cellular and viral proteins that play a crucial role in viral i...
An AP-3-dependent pathway directs phagosome fusion with Rab8 and Rab11 vesicles involved in TLR2 signaling [0.03%]
AP-3依赖的途径可指导吞噬溶酶体与参与TLR2信号转导的Rab8和Rab11小泡融合
Tanja Petnicki-Ocwieja,Bijaya Sharma,Urmila Powale et al.
Tanja Petnicki-Ocwieja et al.
Intracellular compartmentalization of ligands, receptors and signaling molecules has been recognized as an important regulator of inflammation. The toll-like receptor (TLR) 2 pathway utilizes the trafficking molecule adaptor protein 3 (AP-3...
Hox-driven conditional immortalization of myeloid and lymphoid progenitors: Uses, advantages, and future potential [0.03%]
HOX基因驱动的髓系和淋巴系祖细胞条件性永生化：用途、优势及未来前景
Shranjit S Lail,Corey R Arnold,Luiz G N de Almeida et al.
Shranjit S Lail et al.
Those who study macrophage biology struggle with the decision whether to utilize primary macrophages derived directly from mice or opt for the convenience and genetic tractability of immortalized macrophage-like cell lines in in vitro studi...
Correction to: Evolution of factors shaping the endoplasmic reticulum [0.03%]
Correction to: 内质网形成因素的进化
Aspasia Kontou,Emily K Herman,Mark C Field et al.
Aspasia Kontou et al.
Published Erratum
Traffic (Copenhagen, Denmark). 2022 Oct;23(10):521. DOI:10.1111/tra.12867 2022
Roles of long noncoding RNAs and small extracellular vesicle-long noncoding RNAs in type 2 diabetes [0.03%]
长链非编码RNA及小细胞外囊泡-长链非编码RNA在2型糖尿病中的作用
Wenguang Chang,Man Wang,Yuan Zhang et al.
Wenguang Chang et al.
The prevalence of a high-energy diet and a sedentary lifestyle has increased the incidence of type 2 diabetes (T2D). T2D is a chronic disease characterized by high blood glucose levels and insulin resistance in peripheral tissues. The patho...
Cdc42 GTPase activating proteins Rga4 and Rga6 coordinate septum synthesis and membrane trafficking at the division plane during cytokinesis [0.03%]
cdc42 GTP酶活化蛋白Rga4和Rga6在胞质分裂期间协调细胞分裂间隙的隔膜合成及膜转运
Bethany F Campbell,Brian S Hercyk,Ashlei R Williams et al.
Bethany F Campbell et al.
Fission yeast cytokinesis is driven by simultaneous septum synthesis, membrane furrowing and actomyosin ring constriction. The septum consists of a primary septum flanked by secondary septa. First, delivery of the glucan synthase Bgs1 and m...