The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites [0.03%]
疟疾箱中的恶性疟原虫血期寄生虫蛋白分泌抑制剂
Oliver Looker,Madeline G Dans,Hayley E Bullen et al.
Oliver Looker et al.
Plasmodium falciparum parasites which cause malaria, traffic hundreds of proteins into the red blood cells (RBCs) they infect. These exported proteins remodel their RBCs enabling host immune evasion through processes such as cytoadherence t...
Defective axonal transport of endo-lysosomes and dense core vesicles in a Drosophila model of C9-ALS/FTD [0.03%]
轴突转运异常的内溶酶体和致密核心囊泡的果蝇C9-ALS / FTD模型中的研究
Hyun Sung,Thomas E Lloyd
Hyun Sung
A GGGGCC (G4 C2 ) repeat expansion in the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although disruptions in axonal transport are implicated in the pathogenesis of...
Megaviruses contain various genes encoding for eukaryotic vesicle trafficking factors [0.03%]
巨病毒含有多种编码真核细胞囊泡运输因子的基因
Dany Khalifeh,Emilie Neveu,Dirk Fasshauer
Dany Khalifeh
Many intracellular pathogens, such as bacteria and large viruses, enter eukaryotic cells via phagocytosis, then replicate and proliferate inside the host. To avoid degradation in the phagosomes, they have developed strategies to modify vesi...
α-Synuclein fibrils explore actin-mediated macropinocytosis for cellular entry into model neuroblastoma neurons [0.03%]
α-突触核蛋白原纤维探索活性脱氧核糖核酸介导的巨胞饮作用以进入模型神经母细胞瘤神经元内
Pravin Hivare,Joshna Gadhavi,Dhiraj Bhatia et al.
Pravin Hivare et al.
Alpha-synuclein (α-Syn), an intrinsically disordered protein (IDP), is associated with neurodegenerative disorders, including Parkinson's disease (PD or other α-synucleinopathies. Recent investigations propose the transmission of α-Syn p...
Molecular mechanisms of PI4K regulation and their involvement in viral replication [0.03%]
PI4K的调节机制及其在病毒复制中的作用
Jacob A McPhail,John E Burke
Jacob A McPhail
Lipid phosphoinositides are master signaling molecules in eukaryotic cells and key markers of organelle identity. Because of these important roles, the kinases and phosphatases that generate phosphoinositides must be tightly regulated. Viru...
Dajana Tanasic,Nicola Berns,Veit Riechmann
Dajana Tanasic
E-cadherin has a fundamental role in epithelial tissues by providing cell-cell adhesion. Polarised E-cadherin exocytosis to the lateral plasma membrane is central for cell polarity and epithelial homeostasis. Loss of E-cadherin secretion co...
Differential requirements for the Eps15 homology domain proteins EHD4 and EHD2 in the regulation of mammalian ciliogenesis [0.03%]
EHD4和EHD2在哺乳动物纤毛发生调节中的不同要求
Tyler Jones,Naava Naslavsky,Steve Caplan
Tyler Jones
The endocytic protein EHD1 controls primary ciliogenesis by facilitating fusion of the ciliary vesicle and by removal of CP110 from the mother centriole. EHD3, the closest EHD1 paralog, has a similar regulatory role, but initial evidence su...
Extracellular 20S proteasome secreted via microvesicles can degrade poorly folded proteins and inhibit Galectin-3 agglutination activity [0.03%]
胞外20S蛋白酶体通过微泡分泌并降解错误折叠的蛋白质及抑制半乳糖凝集素-3聚集活性
Anne Bonhoure,Laurent Henry,Claudia Bich et al.
Anne Bonhoure et al.
Proteasomes are major non-lysosomal proteolytic complexes localized in the cytoplasm and in the nucleus of eukaryotic cells. Strikingly, high levels of extracellular proteasome have also been evidenced in the plasma (p-proteasome) of patien...
Arabidopsis synaptotagmin 1 mediates lipid transport in a lipid composition-dependent manner [0.03%]
拟南芥Synaptotagmin 1以磷脂组成依赖的方式介导脂质运输
Tiantian Qian,Chenlu Li,Furong Liu et al.
Tiantian Qian et al.
The endoplasmic reticulum (ER)-plasma membrane (PM) contact sites (EPCSs) are structurally conserved in eukaryotes. The Arabidopsis ER-anchored synaptotagmin 1 (SYT1), enriched in EPCSs, plays a critical role in plant abiotic stress toleran...
Melanocore uptake by keratinocytes occurs through phagocytosis and involves protease-activated receptor-2 internalization [0.03%]
黑素通过角质形成细胞的发生性吞噬作用发生并涉及蛋白酶激活受体-2的内吞作用
Hugo Moreiras,Liliana Bento-Lopes,Matilde V Neto et al.
Hugo Moreiras et al.
In the skin epidermis, melanin is produced and stored within melanosomes in melanocytes, and then transferred to keratinocytes. Different models have been proposed to explain the melanin transfer mechanism, which differ essentially in how m...