Melatonin Alleviates Sleep Disturbance-Induced Ovarian Reserve Decline by Suppressing NLRP3-Mediated Pyroptosis in Granulosa Cells [0.03%]
褪黑素通过抑制颗粒细胞中NLRP3介导的细胞焦亡来缓解睡眠障碍诱导的卵巢储备下降
Qunying Fang,Zonghui Qiao,Fangfang Li et al.
Qunying Fang et al.
Sleep disturbance perturbs circadian and immune homeostasis and is increasingly associated with female reproductive dysfunction, yet the underlying cellular mechanisms remain unclear. Here, we identify granulosa cell pyroptosis as a central...
Altered Light-Dark Cycles Promote Osteoclast Activity and Decrease Bone Density in Mice: The Modulatory Role of Melatonin and Sirt3-SOD2 Signaling [0.03%]
光照周期改变促进小鼠破骨细胞活性并降低骨密度：褪黑素和Sirt3-SOD2信号的调节作用
Qian Wang,Mian Zhang,Jun Sun et al.
Qian Wang et al.
The circadian rhythm system plays an essential role in maintaining skeletal homeostasis, yet the precise impact of circadian rhythm abnormalities on bone mineral density (BMD) remains poorly understood. In this study, we systematically inve...
Melatonin-Mediated Alleviation of Plant Response to Heavy Metals: From Integrative Mechanisms to Potential Applications [0.03%]
褪黑素介导的植物重金属响应缓解作用：从整合机制到潜在应用
X Cheng,H Shi
X Cheng
Global heavy metal (HM) stresses pose serious threats to environmental plants and animals. Melatonin has shown potent effects on improving plant stress resistance and phytoremediation upon HM stress, however, the systematic discussion of th...
Combinatory Effects of Indoximod and Melatonin Alleviate Myeloid Derived Suppressor Cells Driven Triple Negative Breast Cancer Progression and Metastasis [0.03%]
吲哚昔尔联合褪黑素通过抑制髓系衍生抑制细胞减轻三阴性乳腺癌进展和转移的协同作用
Ece Oylumlu,Sendegul Yildirim,Aleyna Gezen et al.
Ece Oylumlu et al.
Triple-negative breast cancer (TNBC) is a distinct molecular subtype of breast cancer, characterized by high mortality and metastasis. Indoleamine 2,3-dioxygenase (IDO) is a highly expressed enzyme in cancer cells that contributes to immuno...
Melatonin Counteracts Mechanical Unloading-Induced Bone Loss Through YTHDF3-Mediated m6A Modification of Dapk2 mRNA [0.03%]
褪黑素通过YTHDF3介导的Dapk2 mRNA上的m6A修饰对抗机械卸载引起的骨丢失
Quan Sun,Liqun Xu,Zhikui Li et al.
Quan Sun et al.
Disuse osteoporosis, a consequence of prolonged mechanical unloading, is characterized by bone loss and elevated fracture susceptibility. Although melatonin exhibits bone‑anabolic properties, its mechanistic role in the context of mechanic...
Early Oral Melatonin Supplementation Supports White Matter Maturation in Preterm Infants: Neuroprotective Insights of an Antioxidant Molecule [0.03%]
早期口服褪黑素补充有助于早产儿髓鞘成熟：一种抗氧化分子的神经保护作用初探
Francesca Garofoli,Carlo Asteggiano,Maria Letizia Minniti et al.
Francesca Garofoli et al.
Preterm birth is associated with increased oxidative stress and brain dysmaturation, contributing to adverse neurodevelopmental outcomes. Preterm infants are physiologically unable to produce melatonin during early postnatal life, potential...
Randomized Controlled Trial
Journal of pineal research. 2026 May;78(3):e70147. DOI:10.1111/jpi.70147 2026
Sleep Regularity as a Potentially Modifiable Factor for Osteoporosis Prevention: Interaction With Genetic Susceptibility [0.03%]
睡眠规律作为潜在可改变的预防骨质疏松因素：与遗传易感性的相互作用
Hanhan Zhao,Qiu Xiao,Hao Wang et al.
Hanhan Zhao et al.
Sleep regularity may represent a modifiable risk factor affecting osteoporosis susceptibility, but epidemiological evidence remains scarce. This research sought to analyze the link between sleep regularity parameters and incident osteoporos...
The SlWRKY75-SlASDAC Module Regulates Melatonin Levels to Modulate Leaf Physiological Traits and Seedling Salt Tolerance in Tomato [0.03%]
SlWRKY75-SlASDAC模块通过调节番茄叶绿素含量和耐盐性相关生物合成基因来调控松果体激素褪黑素的水平以调节番茄叶片生理特征及苗期耐盐性
Sen Zhang,Wei Zhang,Yidan Zhou et al.
Sen Zhang et al.
Melatonin is a pleiotropic molecule that plays an important role in regulating plant growth, development and abiotic stress responses. Although melatonin biosynthesis has been extensively characterised, the catabolic pathways that regulate ...
Physiological, Biochemical, and Omics Mechanisms Underlying Melatonin-Mediated Salinity Tolerance and Yield Stability in Adzuki Bean [0.03%]
盐胁迫下赤豆生理生化及组学层面对抗机制研究——褪黑素介导的耐盐性和稳产性响应
Liang Cao,Xinyu Guan,Hui Wen et al.
Liang Cao et al.
Salinity stress is a critical abiotic factor limiting the growth and yield of legume crops by inhibiting photosynthesis, exacerbating oxidative damage, and disrupting the balance of carbon (C) and nitrogen (N) metabolism. This study aimed t...
Melatonin Facts: Musing With the Concept "Melatonin Travels Freely Through Biological Membranes" [0.03%]
褪黑素事实：思考“褪黑素自由通过生物膜”这一概念
Jean A Boutin,Jérôme Leprince,Ralf Jockers
Jean A Boutin
Melatonin has been shown to travel freely through biological membranes. The consequences of this demonstration have been largely underestimated these past years. In particular, the behavior of melatonin during the preparation of samples fro...