Multivariate Data Analysis Methods and Their Application in Lipidomics: A Gentle Comment on Appropriateness and Reliability Criteria [0.03%]
多变量数据分析方法及其在脂质组学中的应用——适当性和可靠性的评价标准商榷
Anna Migni,Desirée Bartolini,Giada Marcantonini et al.
Anna Migni et al.
In response to Yoshiyasu Takefuji's critique regarding the use of Principal Component Analysis (PCA) and Partial Least Squares Discriminant Analysis (PLS-DA) in the study "Melatonin Repairs the Lipidome of Human Hepatocytes Exposed to Cd an...
Proteomic Signatures Underlying Sleep, Circadian Activity Patterns, and Major Chronic Diseases [0.03%]
睡眠、昼夜活动模式及主要慢性疾病的蛋白质组标志物
Jiahe Wei,Hanzhang Wu,Ying Zheng et al.
Jiahe Wei et al.
Rest-activity rhythm and sleep may serve as potential intervention targets for a variety of diseases. However, the underlying biological mechanisms of rest-activity rhythm, sleep, and their proteomic associations with multiple diseases rema...
Direct Peritoneal Resuscitation and Melatonin in the Treatment of Abdominal Sepsis-Induced Lung Injury via Macrophage Metabolic Reprogramming [0.03%]
直接腹腔复苏和褪黑素通过巨噬细胞代谢重组治疗腹部脓毒症引起的肺损伤
Zhirong Zhao,Jiamin Ji,Lan Ming et al.
Zhirong Zhao et al.
Abdominal sepsis and the resultant lung injury lead to high mortality rates, with macrophage metabolic dysfunction and subsequent immune dysregulation being key contributing factors. The clarification of the therapeutic value of direct peri...
Functional Characterization of GNA1 as a Serotonin N-Acetyltransferase Reveals a Key Role in the Serotonin to Melatonin Pathway in Saccharomyces cerevisiae [0.03%]
芽囊酵母GNA1的功能表征及其作为五羟色胺-N-乙酰转移酶在五羟色胺到褪黑素途径中发挥关键作用
Qingjian Zhang,Dongfeng Cheng,Xianghua Tang et al.
Qingjian Zhang et al.
Melatonin (N-acetyl-5-methoxytryptamine) is an evolutionarily conserved molecule with diverse physiological functions across prokaryotes, plants, and animals, including circadian rhythms regulation in animals and developmental modulation in...
Melatonin Prevents Tumor Growth: The Role of Genes Controlling the Circadian Clock, the Cell Cycle, and Angiogenesis [0.03%]
褪黑素抑制肿瘤生长：昼夜节律钟基因、细胞周期基因及生血管基因的作用
Skarleth Cardenas-Romero,Nadia Saderi,Oscar Daniel Ramirez-Plascencia et al.
Skarleth Cardenas-Romero et al.
Recent evidence highlights the protective role of melatonin in a variety of pathological conditions, including multiple types of cancer. Epidemiological studies increasingly suggest that exposure to light at night suppresses melatonin synth...
Melatonin Enhances Aquaporin 4 and Alpha-Syntrophin Interaction by Inhibiting Cyclin-Dependent Kinase 5 Activity to Preserve Glymphatic Function in Neonatal Hypoxic-Ischemic Encephalopathy [0.03%]
褪黑素通过抑制细胞周期蛋白依赖性激酶5活性增强水通道蛋白4和α- syntrophin相互作用以维持缺氧缺血性脑病新生儿甘淋巴系统功能
Yuan Li,Qingqing Ye,Weitian Lu et al.
Yuan Li et al.
The glymphatic system is a critical waste clearance system in the brain, playing an essential role in maintaining homeostasis within the central nervous system. Aquaporin 4 (AQP4), an indispensable component of the glymphatic system, is vit...
Standardized and Calibrated Light Stimuli via Head-Mounted Displays for Investigating the Nonvisual Effects of Light [0.03%]
用于研究光的非视觉效应的标准刺激及校准方法——基于头部佩戴显示设备的方式
Maydel Fernandez-Alonso,Manuel Spitschan
Maydel Fernandez-Alonso
Light influences human physiology profoundly, affecting the circadian clock and suppressing the endogenous hormone melatonin. Experimental studies often employ either homogenous full-field stimulation, or overhead illumination, which are ha...
A Newly Characterized Phytomelatonin Transporter Promotes Tolerance Against Multiple Inorganic Pollutants in Nicotiana benthamiana [0.03%]
一个新的植物褪黑素转运蛋白可提高烟草对多种无机污染物的耐受性
Aditya Banerjee,Aryadeep Roychoudhury
Aditya Banerjee
Melatonin is a known pleiotropic antioxidant and signaling molecule, found in both plants and animals. Although melatonin was found to translocate via the human glucose transporter 1 (GLUT1), any mechanism of transporter-mediated uptake of ...
Melatonin: A Potential Therapy for Osteoporosis With Insights Into Molecular Mechanisms [0.03%]
褪黑素：潜在的治疗骨质疏松方法及其分子机制研究
Ko-Hsiu Lu,Yi-Hsien Hsieh,Renn-Chia Lin et al.
Ko-Hsiu Lu et al.
Melatonin is a versatile neurohormone with diverse molecular functions, including sleep regulation, inflammation reduction, antioxidant activity, immune modulation, and anticancer properties. In bone metabolism, it promotes osteoblast forma...
Melatonin as a Ripening Inhibitor: Enhancing Shelf Life and Quality in Red Banana [0.03%]
褪黑素作为抑制香蕉后熟的外源物质延长红皮香蕉保鲜期并改善品质的研究
Anchana Kandasamy,Kavitha Chinnasamy,Suresh Kumar Paramasivam et al.
Anchana Kandasamy et al.
In climacteric fruits like banana (Musa spp.), ripening is driven by ethylene production and increased respiration, leading to rapid softening, quality loss, and disease susceptibility. This study was aimed to evaluate the effect of posthar...