Integrated Omics Analysis Reveals Melatonin-Mediated Chilling-Responsive Physiological, Antioxidant, and Metabolic Mechanisms Underlying Cold Resistance in Wampee [0.03%]
综合组学分析揭示了番石榴中褪黑素介导的冷响应生理、抗氧化和代谢机制背后的耐寒性机制
Shujun Peng,Yongyan Huang,Xiaoyue Zhu et al.
Shujun Peng et al.
Wampee (Clausena lansium) is a tropical and southern subtropical fruit tree whose productivity is limited by low-temperature stress (LTS). This study investigated the physiochemical and molecular mechanisms by which melatonin (MLT) enhanc...
Melatonin-Mediated Modulation of Polyamines Enhances Drought Tolerance in Foxtail Millet (Setaria italica L.) [0.03%]
褪黑素介导的多胺调节可增强青狗尾草的抗旱性
Qifeng Shi,Guo Wang,Tao Zhang et al.
Qifeng Shi et al.
Melatonin have been proposed as a potential alternative in enhancing drought tolerance. However, the mechanisms underlying remain poorly understood. This study tested the hypothesis that melatonin improves drought tolerance by regulating po...
Circadian-Related Serotonin/Melatonin Level Modulates Cisplatin Ototoxicity Susceptibility Depended on NOS3-NO Pathway [0.03%]
生物钟相关色氨酸/褪黑素水平通过一氧化氮合酶3-一氧化氮途径调节顺铂的耳毒性作用机制研究
Siyu Qiu,Shiyi Cai,Rong Xie et al.
Siyu Qiu et al.
Hearing impairment is attributed to factors such as age, genetic predisposition, and environmental influences, among which environmental factors are considered modifiable. Among various environmental factors, the role of poor lifestyle habi...
Preventive Antiarrhythmic Properties of Melatonin in Experimental Diabetic Cardiomyopathy in Rats [0.03%]
实验研究：抗氧化剂褪黑素预防糖尿病心肌病大鼠的室性心律失常作用
Alexey O Ovechkin,Mikhail A Gonotkov,Alena S Abramochkina et al.
Alexey O Ovechkin et al.
Diabetes mellitus (DM) promotes cardiac arrhythmias, whereas melatonin confers antiarrhythmic effects. Cellular targets modified by DM and melatonin largely overlap, which warrants testing melatonin as an antiarrhythmic agent in DM. Herein,...
Melatonin Alleviates Sleep Disturbance-Induced Ovarian Reserve Decline by Suppressing NLRP3-Mediated Pyroptosis in Granulosa Cells [0.03%]
褪黑素通过抑制颗粒细胞中NLRP3介导的细胞焦亡来缓解睡眠障碍诱导的卵巢储备下降
Qunying Fang,Zonghui Qiao,Fangfang Li et al.
Qunying Fang et al.
Sleep disturbance perturbs circadian and immune homeostasis and is increasingly associated with female reproductive dysfunction, yet the underlying cellular mechanisms remain unclear. Here, we identify granulosa cell pyroptosis as a central...
Altered Light-Dark Cycles Promote Osteoclast Activity and Decrease Bone Density in Mice: The Modulatory Role of Melatonin and Sirt3-SOD2 Signaling [0.03%]
光照周期改变促进小鼠破骨细胞活性并降低骨密度：褪黑素和Sirt3-SOD2信号的调节作用
Qian Wang,Mian Zhang,Jun Sun et al.
Qian Wang et al.
The circadian rhythm system plays an essential role in maintaining skeletal homeostasis, yet the precise impact of circadian rhythm abnormalities on bone mineral density (BMD) remains poorly understood. In this study, we systematically inve...
Melatonin-Mediated Alleviation of Plant Response to Heavy Metals: From Integrative Mechanisms to Potential Applications [0.03%]
褪黑素介导的植物重金属响应缓解作用：从整合机制到潜在应用
X Cheng,H Shi
X Cheng
Global heavy metal (HM) stresses pose serious threats to environmental plants and animals. Melatonin has shown potent effects on improving plant stress resistance and phytoremediation upon HM stress, however, the systematic discussion of th...
Combinatory Effects of Indoximod and Melatonin Alleviate Myeloid Derived Suppressor Cells Driven Triple Negative Breast Cancer Progression and Metastasis [0.03%]
吲哚昔尔联合褪黑素通过抑制髓系衍生抑制细胞减轻三阴性乳腺癌进展和转移的协同作用
Ece Oylumlu,Sendegul Yildirim,Aleyna Gezen et al.
Ece Oylumlu et al.
Triple-negative breast cancer (TNBC) is a distinct molecular subtype of breast cancer, characterized by high mortality and metastasis. Indoleamine 2,3-dioxygenase (IDO) is a highly expressed enzyme in cancer cells that contributes to immuno...
Melatonin Counteracts Mechanical Unloading-Induced Bone Loss Through YTHDF3-Mediated m6A Modification of Dapk2 mRNA [0.03%]
褪黑素通过YTHDF3介导的Dapk2 mRNA上的m6A修饰对抗机械卸载引起的骨丢失
Quan Sun,Liqun Xu,Zhikui Li et al.
Quan Sun et al.
Disuse osteoporosis, a consequence of prolonged mechanical unloading, is characterized by bone loss and elevated fracture susceptibility. Although melatonin exhibits bone‑anabolic properties, its mechanistic role in the context of mechanic...
Early Oral Melatonin Supplementation Supports White Matter Maturation in Preterm Infants: Neuroprotective Insights of an Antioxidant Molecule [0.03%]
早期口服褪黑素补充有助于早产儿髓鞘成熟：一种抗氧化分子的神经保护作用初探
Francesca Garofoli,Carlo Asteggiano,Maria Letizia Minniti et al.
Francesca Garofoli et al.
Preterm birth is associated with increased oxidative stress and brain dysmaturation, contributing to adverse neurodevelopmental outcomes. Preterm infants are physiologically unable to produce melatonin during early postnatal life, potential...
Randomized Controlled Trial
Journal of pineal research. 2026 May;78(3):e70147. DOI:10.1111/jpi.70147 2026