AZD2693, a PNPLA3 antisense oligonucleotide, for the treatment of MASH in 148M homozygous participants: two randomized phase I trials [0.03%]
阿泽丹二六九三（一种PNPLA3反义寡核苷酸）治疗148M纯合子受试者中的混合型非酒精性 steatohepatitis患者：两项一期随机试验
Javier Armisen,Mitra Rauschecker,Janeli Sarv et al.
Javier Armisen et al.
Background & aims: A common genetic variant (rs738409) encoding isoleucine to methionine at position 148 in the PNPLA3 protein is a determinant of hepatic steatosis, inflammation, fibrosis, cirrhosis, and liver-related mo...
Amber G Bozward,Scott P Davies,Sean M Morris et al.
Amber G Bozward et al.
The lymphocyte population must traverse a complex path throughout their journey to the liver. The signals which these cells must detect, including cytokines, chemokines and other soluble factors, steer their course towards further crosstalk...
Real-world effectiveness and safety of bulevirtide monotherapy for up to 96 weeks in patients with HDV-related cirrhosis [0.03%]
贝拉西韦单药治疗HDV相关肝硬化患者长达96周的疗效和安全性：现实世界证据
Elisabetta Degasperi,Maria Paola Anolli,Mathias Jachs et al.
Elisabetta Degasperi et al.
Background and aims: Bulevirtide (BLV) 2 mg/day is EMA approved for treatment of compensated chronic hepatitis due to Delta virus (HDV) infection, however real-life data in large cohorts of patients with cirrhosis are lac...
Spliced exon9 ADRM1 promotes liver oncogenicity via selective degradation of tumor suppressor FBXW7 [0.03%]
通过选择性降解肿瘤抑制因子FBXW7促进肝致癌性的拼接外显子9 ADRM1变异体
Yanmei Sun,Mingjing Xu,Ho Lee Wan et al.
Yanmei Sun et al.
Background & aims: The ubiquitin receptor ADRM1/Rpn13 governs the specificity of eukaryotic protein degradation. By SMRT sequencing, we first discovered a novel spliced variant of ADRM1 with a skipped exon 9, termed ADRM1...
TGM2-mediated histone serotonylation promotes HCC progression via MYC signalling pathway [0.03%]
TGM2介导的组蛋白血清素化通过MYC信号通路促进肝癌进展
Renshun Dong,Tianci Wang,Wei Dong et al.
Renshun Dong et al.
Background & aims: Hepatocellular carcinoma (HCC) is an aggressive malignancy with few effective treatment options. H3Q5ser, a serotonin-based histone modification mediated by transglutaminase 2 (TGM2), affects diverse bi...
Laia Aceituno,Annabel Katherine Gravely,Grainne Mary O&#x;Kane et al.
Laia Aceituno et al.
Host hepatocyte senescence determines the success of hepatocyte transplantation in a mouse model of liver injury [0.03%]
宿主肝细胞衰老决定肝损伤小鼠模型中肝细胞移植的成败
Victoria L Gadd,Sofia Ferreira-Gonzalez,Tak Yung Man et al.
Victoria L Gadd et al.
Background & aims: Hepatocyte transplantation has shown promise for genetic diseases of the hepatocytes but to date has shown limited efficacy for non-genetic forms of severe liver injury. Limited cell engraftment and poo...
Response to: Rethinking Methodology and Data Integrity in Mendelian Randomization: Insights from Air Pollution and MASLD Research [0.03%]
对孟德尔随机化方法和数据完整性的重新思考：来自空气污染和MASLD研究的见解
Shanshan Ran,Jingyi Zhang,Hualiang Lin
Shanshan Ran
Optimal Timing To Initiate Antiviral Prophylaxis of MTCT: More Required to Be Done [0.03%]
预防母婴传播抗病毒药物的起始时机：更需努力的工作
Ruixuan Hong,Xiaoyun Liu,Xueru Yin
Ruixuan Hong
Targeting Tumour Endothelial Cells in Liver Cancer: The end of beginning [0.03%]
肝癌肿瘤内皮细胞的靶向治疗：“黎明前黑暗的终结”
Xiaohang Long,Tsz Tung Kwong,Alfred Sze-Lok Cheng et al.
Xiaohang Long et al.