First evidence of Tityus confluens Borelli, 1899 (Buthidae) venom altering purine metabolism in rat blood cells [0.03%]
首次证据显示Tityus confluens Borelli, 1899（Buthidae）毒液改变大鼠血液细胞的嘌呤代谢
Romário da Silva Portilho,Igor Leal Brito,Andreza Negreli Santos et al.
Romário da Silva Portilho et al.
Purinergic signaling pathways play crucial roles in regulating hemostatic and inflammatory responses, both of which are impacted by scorpion envenomation. Scorpion venoms are complex mixtures of various toxins, such as peptides, enzymes, an...
SCH58261 effectively prevents the reduction in excitability of striatal MSNs in mice following 20 h of sleep deprivation [0.03%]
SCH58261有效防止小鼠在20小时睡眠剥夺后的纹状体MSN兴奋性降低
Jin Peng,Xinyu Huang,Peijie Liu et al.
Jin Peng et al.
Adenosine, a sleep-associated neuromodulator, is crucial in various physiological and pathological processes. Previous studies have demonstrated that sleep deprivation (SD) alters striatal neuronal activity. In this study, we used in vitro ...
A2B adenosine receptor-triggered intracellular calcium mobilization: Cell type-dependent involvement of Gi, Gq, Gs proteins and protein kinase C [0.03%]
A2B腺苷受体引发的胞内钙动员：Gi,GqGs蛋白和蛋白激酶C的细胞类型依赖性参与
Zhan-Guo Gao,Ray R Gao,Clayton K Meyer et al.
Zhan-Guo Gao et al.
Activation of PLCβ enzymes by Giβγ and Gαq/11 proteins is a common mechanism to trigger cytosolic Ca2+ increase. We and others reported that Gαq/11 inhibitor FR900359 (FR) can inhibit both Gαq- and, surprisingly, Giβγ-mediated intra...
Adventures in translation [0.03%]
翻译奇遇记
Bruce Cronstein,Sid Angle
Bruce Cronstein
Extracellular ATP regulates phagocytic activity, mitochondrial respiration, and cytokine secretion of human astrocytic cells [0.03%]
胞外ATP调节人源星形胶质细胞的吞噬活性、线粒体呼吸及细胞因子分泌
Sijie Shirley Yang,Noah A H Brooks,Dylan E Da Silva et al.
Sijie Shirley Yang et al.
The two main glial cell types of the central nervous system (CNS), astrocytes and microglia, are responsible for neuroimmune homeostasis. Recent evidence indicates astrocytes can participate in removal of pathological structures by becoming...
Purinergic signaling in health: special issue of purines 2022 in Brazil [0.03%]
嘌呤能信号在健康中的作用：2022年巴西纯呤会议特刊
Henning Ulrich,Carla I Tasca,Claudiana Lameu
Henning Ulrich
Purinergic P2Y1 and P2Y12 receptors control enteric nervous system activity through neuro-glia-macrophage crosstalk [0.03%]
嘌呤能P2Y1和P2Y12受体通过神经-胶质-巨噬细胞通讯控制肠神经系统活动
Blake J Hendler,Jonathon L McClain,Aurora Zilli et al.
Blake J Hendler et al.
Purines are important mediators of intercellular communication in the enteric nervous system (ENS) that participate in physiological gut functions and disease. Purinergic transmission is prominent in mechanisms of crosstalk between enteric ...
The role of the P2X7 receptor in inactivated SARS-CoV-2-induced lung injury [0.03%]
P2X7受体在灭活SARS-CoV-2诱导的肺损伤中的作用
N C Carvalho-Barbosa,Fabiana Cristina-Rodrigues,Jairo R Temerozo et al.
N C Carvalho-Barbosa et al.
Purinergic signaling plays a role in the pathophysiology of different viral infections. Recently, we showed that COVID-19 increases extracellular ATP levels, which may amplify the pro-inflammatory signals in the disease. The P2X7 receptor c...
Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells [0.03%]
P2X7受体拮抗剂可抑制肝癌细胞增殖
Xinxing Tantai,Xin Yang,Xinyuan Liu et al.
Xinxing Tantai et al.
The P2X7 receptor, an ATP-gated ion channel which belongs to the P2X receptor family, plays critical roles in recognizing extracellular adenosine 5'-triphosphate (ATP) and is widely expressed in most tumor cells as well as inflammatory cell...
CD39 activities in the treated acupoints contributed to the analgesic mechanism of acupuncture on arthritis rats [0.03%]
治疗穴位的CD39活性参与了针刺镇痛的作用机制——以类风湿关节炎大鼠模型为例研究
Yu-Jia Li,Jie Lin,Si-Qi Tang et al.
Yu-Jia Li et al.
Our previous work had identified that at the acupuncture point (acupoint), acupuncture-induced ATP release was a pivotal event in the initiation of analgesia. We aimed to further elucidate the degradation of ATP by CD39. Acupuncture was adm...