Luigia Ruo,Federica Fortuna,Marianna Grignolo et al.
Luigia Ruo et al.
Extracellular adenosine triphosphate (eATP) is a hallmark of inflammatory and tumor-associated microenvironments, where it functions as a key extracellular signalling molecule through activation of purinergic receptors. In the gastrointesti...
Mixed circuit training as a non-pharmacological strategy to improve platelet function and oxidative balance in type 2 diabetes: role of purinergic signaling [0.03%]
Lucas Macedo Chaves,Samantha Nuncio Prestes,André Campos De Lima et al.
Lucas Macedo Chaves et al.
This study investigates the impact of a 16-week mixed circuit training (MCT) program on purinergic signaling and oxidative stress markers in women with type 2 diabetes mellitus (T2DM), focusing on its potential to modulate platelet-related ...
Phenolic compounds and chemotherapeutic agents differentially regulate P2X receptor subtypes in malignant melanoma [0.03%]
酚类化合物和化学治疗剂可区别调节恶性黑色素瘤中的P2X受体亚型
Serkan Sen,Sefa Celik
Serkan Sen
Melanoma is an aggressive malignancy characterized by high metastatic potential and resistance to conventional therapies. Emerging evidence suggests that purinergic P2X receptors, particularly P2X7, play critical roles in regulating tumor c...
The P2X7 receptor/NLRP3 inflammasome signaling axis in sepsis: molecular mechanisms, organ-specific pathophysiology, and emerging therapeutic strategies [0.03%]
P2X7受体/NLRP3炎性小体信号通路在脓毒症中的作用：分子机制、器官特异性病理生理学和新兴治疗策略
Hilal Üstündağ
Hilal Üstündağ
Sepsis remains a leading cause of mortality in intensive care units worldwide, representing life-threatening organ dysfunction arising from dysregulated host responses to infection. The purinergic P2X7 receptor (P2X7R) and the NOD-like rece...
The potential role of adenosinergic pathway and methylxanthines in Parkinson's disease: Blowing in the wind or not [0.03%]
腺苷能通路和甲基黄嘌呤在帕金森病中的潜在作用：被风刮走了还是没走？
Alaa Ismail,Hayder M Al-Kuraishy,Ali I Al-Gareeb et al.
Alaa Ismail et al.
Parkinson's disease (PD) is a systemic neurodegenerative disease, and is mainly related to the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Despite extensive research regarding PD neuropatho...
The biphasic regulatory effect of adenosine A2B receptor in ischemic brain injury and its therapeutic potential [0.03%]
腺苷A2B受体在缺血性脑损伤中的双向调节作用及其潜在治疗价值
Xu Rui,Wang Xi,Li Mengzhu et al.
Xu Rui et al.
Ischemic brain injury is the leading cause of neurological disability and death worldwide. Adenosine A2B receptor (A2BR) is a member of the G protein-coupled receptor family, playing a crucial role in regulating excitotoxicity, inflammation...
Extracellular ATP induces the proinflammatory phenotype transition of MH7A cells by activating P2X7 receptor [0.03%]
胞外三磷酸腺苷通过活化P2X7受体诱导MH7A细胞向促炎表型转化
Chengxiang Wang,Jiayao Hao,Yan Liu et al.
Chengxiang Wang et al.
The transition of fibroblast-like synoviocytes (FLS) toward a proinflammatory phenotype is a hallmark of rheumatoid arthritis (RA), with proinflammatory RA-FLS exacerbating joint destruction via hyperproliferation, enhanced migration/invasi...
Modulation of immune responses by opioids through toll-like and P2X receptor signaling in COVID-19 [0.03%]
阿片类药物通过 Toll 样和 P2X 受体信号调节 COVID-19 免疫反应
Mohammad Abbas Sheikholeslami,Siavash Parvardeh,Shiva Ghafghazi et al.
Mohammad Abbas Sheikholeslami et al.
The pathogenesis of COVID-19 involves complex interactions between viral replication and host immune dysregulation, mediated by toll-like receptors (TLRs) and P2X receptors (P2XRs). These receptors detect pathogen- and damage-associated mol...
Purinergic P2X7 receptor signaling in anxiety: Roles of stress-related neuroinflammatory mechanisms and therapeutic horizons [0.03%]
焦虑症中嘌呤能P2X7受体信号通路的作用：应激相关神经炎症机制及治疗前景的观点综述
Simranpreet Kaur,Vikash Kumar Giri,Khadga Raj Aran
Simranpreet Kaur
Anxiety is a psychological state marked by constant uneasiness, fear, or stress in response to an actual or perceived danger, resulting in physical changes such as elevated cardiac activity, poor concentration, and restlessness. The excessi...
In tribute to Francesco Di Virgilio, a great scientist and a wonderful friend [0.03%]
缅怀伟大的科学家和杰出的朋友弗朗西斯科·迪维吉里奥教授
Simonetta Falzoni,Anna Lisa Giuliani,Elena Adinolfi et al.
Simonetta Falzoni et al.
Francesco Di Virgilio, one of the giants of purinergic signalling, died suddenly on September 22, 2024, which is an immense loss to so many friends and colleagues and especially to his beloved wife, Dorianna. Here, 1 year on, we pay tribute...