The biphasic regulatory effect of adenosine A2B receptor in ischemic brain injury and its therapeutic potential [0.03%]
腺苷A2B受体在缺血性脑损伤中的双向调节作用及其潜在治疗价值
Xu Rui,Wang Xi,Li Mengzhu et al.
Xu Rui et al.
Ischemic brain injury is the leading cause of neurological disability and death worldwide. Adenosine A2B receptor (A2BR) is a member of the G protein-coupled receptor family, playing a crucial role in regulating excitotoxicity, inflammation...
Extracellular ATP induces the proinflammatory phenotype transition of MH7A cells by activating P2X7 receptor [0.03%]
胞外三磷酸腺苷通过活化P2X7受体诱导MH7A细胞向促炎表型转化
Chengxiang Wang,Jiayao Hao,Yan Liu et al.
Chengxiang Wang et al.
The transition of fibroblast-like synoviocytes (FLS) toward a proinflammatory phenotype is a hallmark of rheumatoid arthritis (RA), with proinflammatory RA-FLS exacerbating joint destruction via hyperproliferation, enhanced migration/invasi...
Modulation of immune responses by opioids through toll-like and P2X receptor signaling in COVID-19 [0.03%]
阿片类药物通过 Toll 样和 P2X 受体信号调节 COVID-19 免疫反应
Mohammad Abbas Sheikholeslami,Siavash Parvardeh,Shiva Ghafghazi et al.
Mohammad Abbas Sheikholeslami et al.
The pathogenesis of COVID-19 involves complex interactions between viral replication and host immune dysregulation, mediated by toll-like receptors (TLRs) and P2X receptors (P2XRs). These receptors detect pathogen- and damage-associated mol...
Purinergic P2X7 receptor signaling in anxiety: Roles of stress-related neuroinflammatory mechanisms and therapeutic horizons [0.03%]
焦虑症中嘌呤能P2X7受体信号通路的作用：应激相关神经炎症机制及治疗前景的观点综述
Simranpreet Kaur,Vikash Kumar Giri,Khadga Raj Aran
Simranpreet Kaur
Anxiety is a psychological state marked by constant uneasiness, fear, or stress in response to an actual or perceived danger, resulting in physical changes such as elevated cardiac activity, poor concentration, and restlessness. The excessi...
In tribute to Francesco Di Virgilio, a great scientist and a wonderful friend [0.03%]
缅怀伟大的科学家和杰出的朋友弗朗西斯科·迪维吉里奥教授
Simonetta Falzoni,Anna Lisa Giuliani,Elena Adinolfi et al.
Simonetta Falzoni et al.
Francesco Di Virgilio, one of the giants of purinergic signalling, died suddenly on September 22, 2024, which is an immense loss to so many friends and colleagues and especially to his beloved wife, Dorianna. Here, 1 year on, we pay tribute...
Tumor-driven purinergic signalling promotes RBFOX1 loss and chemotherapy-induced cardiotoxicity [0.03%]
肿瘤驱动的嘌呤能信号促进RBFOX1丢失和化学疗法诱导的心脏毒性
Abdel-Aziz S Shatat
Abdel-Aziz S Shatat
A2AR antagonist IDPU facilitates the restoration of mitochondrial dynamics in 6-OHDA-induced primary mid-brain neuronal cells, via regulating p38MAPK/Parkin/DJ-1/DRP1 axis [0.03%]
A2AR拮抗剂IDPU通过调节p38MAPK/Parkin/DJ-1/DRP1轴促进6-OHDA诱导的中脑原代神经元细胞线粒体动力学恢复
Vaishali Walecha,Jyoti Mishra,Tuithung Sophronea et al.
Vaishali Walecha et al.
Parkinson's disease (PD) is marked by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Adenosine receptors (A2ARs) modulate the striatopallidal non-dopaminergic pathway to alleviate PD symptoms. In the present ...
Jia-Jia Li,Yong Tang,Peter Illes
Jia-Jia Li
P2X4 receptors on myeloid cells mediate tissue injury in a model of trauma and hemorrhagic shock in male mice [0.03%]
雄性小鼠创伤和失血性休克模型中髓系细胞上的P2X4受体介导组织损伤
Taha Kelestemur,Zoltán H Németh,Pal Pacher et al.
Taha Kelestemur et al.
Trauma and hemorrhagic shock (T/HS) trigger systemic inflammation and multiorgan injury, yet the molecular mediators of this response remain incompletely defined. Purinergic receptors, including P2X4 and P2X7, are key regulators of innate i...
Brilliant blue G enhances cardiac function and suppresses ventricular arrhythmias by attenuating inflammation and fibrosis after post-myocardial infarction in rats [0.03%]
brilliant blue G可通过减轻炎症和纤维化增强心功能并抑制心肌梗死后大鼠室性心律失常
Zefei Jiang,Xuan Li,Masaomi Miura et al.
Zefei Jiang et al.
Myocardial infarction (MI) is a leading cause of heart failure and ventricular arrhythmias, driven by excessive inflammation and adverse cardiac remodeling. The purinergic P2X7 receptor (P2X7R) plays a critical role in acute MI, however, th...