Patients with periodontal disease demonstrates changes in purinergic and inflammatory markers in PBMCs, serum and saliva [0.03%]
牙周病患者外周血单个核细胞，血清和唾液中嘌呤能及炎性标记物的变化
Silviane Cunico Carneiro Füchter,Bárbara Stolarski,Daiane Manica et al.
Silviane Cunico Carneiro Füchter et al.
Periodontal disease (PD) is characterized by the presence of a chronic inflammatory process, due to the accumulation of bacterial biofilm and the host's response to these pathogens, resulting in the destruction of the supporting tissues of ...
Effects of nanoflubendazole and purinergic signaling modulation in overcoming neuroblastoma chemoresistance [0.03%]
纳米氟苯达唑和嘌呤能信号调节在克服神经母细胞瘤化学耐药性中的作用
Renata Siqueira de Mello,Carolina Adriane Bento,Rafael de Oliveira Faria et al.
Renata Siqueira de Mello et al.
Neuroblastoma is a pediatric tumor accounting for approximately 8% of childhood cancers and is associated with high mortality rates among children aged 1 to 5 years. Standard treatments often fall short, leading to recurrence and metastasis...
Macrophage P2Y6 receptor signalling as a key mediator and therapeutic target in atherosclerosis [0.03%]
巨噬细胞P2Y6受体信号传导作为动脉粥样硬化中的关键介质和治疗靶点
Aida Collado,Zhichao Zhou
Aida Collado
Atherosclerosis, a chronic inflammatory disease driven by lipid deposition and immune cell activation, remains a leading cause of cardiovascular morbidity and mortality. Emerging evidence highlights the role of purinergic signalling in athe...
A step-by-step protocol based on data mining to explore purinergic signaling in glioblastoma [0.03%]
基于数据挖掘探索胶质母细胞瘤中嘌呤能信号的逐步协议
Martina Bedeschi,Ankita Agrawal,Elena Adinolfi et al.
Martina Bedeschi et al.
Over the past few years, transcriptomics has emerged as a pillar for modern scientific research, enabling the comprehensive profiling of gene expression. The availability of large-scale public datasets, such as NCBI Gene Expression Omnibus,...
T cell-derived adenosine regulates fibroblast IL-6 formation via A2B receptors in the infarcted heart [0.03%]
心肌梗死中心肌成纤维细胞通过A2B受体调节由T淋巴细胞源腺苷调控的IL-6形成
Tong Jiao,Zhichao Zhou
Tong Jiao
Elevated interleukin-6 (IL-6) levels are linked to an increased risk of cardiovascular mortality in myocardial infarction (MI). Targeting IL-6 and its downstream signalling pathways represents a therapeutic strategy; however, its cellular s...
Establishment and behavioural characterization of a novel constitutive P2X7 receptor knockout mouse line [0.03%]
新型构成性P2X7受体基因敲除小鼠品系的建立及其行为特征分析
Iven-Alex von Mücke-Heim,Judit Oldekamp,Michael W Metzger et al.
Iven-Alex von Mücke-Heim et al.
The P2X7 receptor is an adenosine triphosphate (ATP)-gated ion channel expressed in different cell types of the brain. Polymorphisms in the P2RX7 gene have repeatedly been associated with psychiatric disorders including major depression. De...
Combined oral contraceptives alter ectonucleotidase and adenosine deaminase activities in peripheral blood cells [0.03%]
复方口服避孕药会改变外周血细胞的核苷酸酶和腺苷脱氨酶活性
Bruna Pache Moreschi,Romário da Silva Portilho,Andreza Negreli Santos et al.
Bruna Pache Moreschi et al.
Hormonal contraceptives, one of the most widely used contraceptive methods, are associated with the development of thromboembolism. Purinergic mediators such as soluble agonists, ectonucleotidases, and receptors play a prominent role in reg...
Reprogramming the tumor microenvironment by targeting cytidine deaminase in pancreatic ductal adenocarcinoma tumors: implications for the role of P2Y6 receptors [0.03%]
通过靶向胰腺导管腺癌肿瘤中的胞嘧啶脱氨酶来重新编程肿瘤微环境：P2Y6受体的作用意义
Abdel-Aziz S Shatat
Abdel-Aziz S Shatat
Immunotherapies, such as immune checkpoint inhibitors (ICI), anti-cancer vaccines and adoptive T cell transfer, are promising treatments for cancer patients. However, ICI have not shown therapeutic benefit for most mismatch repair-proficien...
Charles Kennedy
Charles Kennedy
Chloe Keduan Li,Karen Joan Gregory,Manuela Jörg
Chloe Keduan Li