Beneficial effects of levetiracetam in streptozotocin-induced rat model of Alzheimer's disease [0.03%]
左旋雷特匹坦对链佐星诱导的阿尔茨海默病大鼠模型的有益作用
Mohaddeseh Sadat Alavi,Sahar Fanoudi,Mahmoud Hosseini et al.
Mohaddeseh Sadat Alavi et al.
Alzheimer's disease (AD) is the most common neurodegenerative disorder among the elderly. In the light of increasing AD prevalence and lack of effective treatment, new strategies to prevent or reverse this condition are needed. Levetiraceta...
Age-dependent aggregation of α-synuclein in the nervous system of gut-brain axis is associated with caspase-1 activation [0.03%]
轴突脑肠轴神经系统的α-突触核蛋白的年龄依赖性聚集与caspase-1活化有关
Qi Hu,Mei Hong,Mengyang Huang et al.
Qi Hu et al.
α-Synuclein (α-Syn) plays a key role in the development of Parkinson' desease (PD). As aging is acknowledged to be the greatest risk factor for PD, here we investigated α-Syn expression in the ileum, thoracic spinal cord, and midbrain of...
Protective effect of calpain inhibitors against manganese-induced toxicity in rats [0.03%]
钙蛋白酶抑制剂对锰致大鼠毒性的保护作用
I S Ivleva,A P Ivlev,N S Pestereva et al.
I S Ivleva et al.
Development of manganism is a major complication of manganese exposure in which neurological dysfunction is linked to accumulation of metal in the brain. Current therapies do not prevent progression of the disease. Therefore, development of...
Drug delivery for neuronopathic lysosomal storage diseases: evolving roles of the blood brain barrier and cerebrospinal fluid [0.03%]
药物输送用于治疗神经内溶酶体贮积病：血脑屏障和脑脊液的演变作用
Yuji Sato,Kohtaro Minami,Toru Hirato et al.
Yuji Sato et al.
Whereas significant strides have been made in the treatment of lysosomal storage diseases (LSDs), the neuronopathy associated with these diseases remains impervious mainly because of the blood-brain barrier (BBB), which prevents delivery of...
LncRNA CEBPA-AS1 knockdown prevents neuronal apoptosis against oxygen glucose deprivation/reoxygenation by regulating the miR-455/GPER1 axis [0.03%]
CEPBA-AS1敲低通过调节miR-455/GPER1轴预防缺氧葡萄糖剥夺/复氧诱导的神经元凋亡
Jun Peng,Zheng-Tao Yu,Rong-Jun Xiao et al.
Jun Peng et al.
Ischemic stroke (IS) is a common nervous system disease, which is a major cause of disability and death in the world. In present study, we demonstrated a regulatory mechanism of CCAAT/enhancer binding protein-alpha antisense 1 (CEBPA-AS1) i...
Sodium tanshinone IIA sulfonate improves cognitive impairment via regulating Aβ transportation in AD transgenic mouse model [0.03%]
水溶性丹参酮ⅡA磺酸钠通过调节AD小鼠模型中Aβ的运输改善认知障碍
Hui-Han Ma,Can Wan,Lu-Di Zhang et al.
Hui-Han Ma et al.
Alzheimer's disease (AD) is a most common neurodegenerative disease. Sodium Tanshinone IIA Sulfonate (STS) has been reported to ameliorate AD pathology. However, the underlying mechanism is still unclear. In this study, AD transgenic mouse ...
Circ_0003611 acts as a miR-885-5p sponge to aggravate the amyloid-β-induced neuronal injury in Alzheimer's disease [0.03%]
circ_0003611通过海绵作用于mi r-885-5p加重阿尔茨海默病中淀粉样蛋白诱发的神经元损伤
Weihua Pan,Yirui Hu,Lihong Wang et al.
Weihua Pan et al.
Alzheimer's disease (AD) is a chronic degenerative disease in the central nervous system and circular RNAs (circRNAs) are identified as essential regulators in AD. The current research was designed for exploration of circ_0003611 in AD. Cir...
Effects of Rosemary Oil (Rosmarinus officinalis) supplementation on the fate of the transplanted human olfactory bulb neural stem cells against ibotenic acid-induced neurotoxicity (Alzheimer model) in rat [0.03%]
补充鼠尾草油对移植的人嗅球神经干细胞命运和伊博酸诱导的神经毒性（阿尔茨海默病模型）大鼠的影响
Shaymaa Rezk,Samah Lashen,Mohamed El-Adl et al.
Shaymaa Rezk et al.
Rosemary oil (ROO) is known to have multiple pharmacological effects: it is an antioxidant, anti-inflammatory, and cytoprotective. In the present study, we examined the effects of ROO on Human olfactory bulb neuronal stem cells (hOBNSCs) af...
Downregulation of miR-185 is a common pathogenic event in 22q11.2 deletion syndrome-related and idiopathic schizophrenia [0.03%]
22q11.2微缺失综合征相关性和特发性精神分裂症中共同存在miR-185下调事件
Hani Sabaie,Jalal Gharesouran,Mohammad Reza Asadi et al.
Hani Sabaie et al.
Schizophrenia (SCZ) is known as a complicated mental disease with an unknown etiology. The microdeletion of 22q11.2 is the most potent genetic risk factor. Researchers are still trying to find which genes in the deletion region are linked t...
Regulation of microRNAs in Alzheimer´s disease, type 2 diabetes, and aerobic exercise training [0.03%]
阿尔茨海默病、2型糖尿病和有氧运动训练中的微小核糖核酸的调节
Ricardo Augusto Leoni De Sousa,Alex Cleber Improta-Caria
Ricardo Augusto Leoni De Sousa
Alzheimer's disease (AD) is the most common type of dementia. The evolution and aggregation of amyloid beta (β) oligomers is linked to insulin resistance in AD, which is also the major characteristic of type 2 diabetes (T2D). Being physica...