Age-dependent aggregation of α-synuclein in the nervous system of gut-brain axis is associated with caspase-1 activation
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α-Synuclein (α-Syn) plays a key role in the development of Parkinson' desease (PD). As aging is acknowledged to be the greatest risk factor for PD, here we investigated α-Syn expression in the ileum, thoracic spinal cord, and midbrain of young (1-month-old)... ...
