Oleuropein regulates neuronal survival and Histone acetylation in Parkinson's disease: cellular and epigenetic insights [0.03%]
橄榄苦素调节帕金森病中的神经元存活和组蛋白乙酰化：细胞及表观遗传学见解
Richa Singh,Aaina Singh Rathore,Arunim Shah et al.
Richa Singh et al.
The complex physiology of Parkinson's disease (PD) and its limited response to conventional therapies make it a challenging condition to manage. Evidence suggests that both environmental and genetic variables play essential roles in the pro...
Polysaccharide-driven gut microbial metabolism in neurodegenerative brain diseases: from SCFAs and tryptophan catabolites to neuroinflammatory regulation [0.03%]
多糖驱动的肠道微生物代谢在神经退行性脑疾病中的作用：从短链脂肪酸和色氨酸分解产物到对神经炎症的调节
Chengqi Peng,Lingxiao Chen,Zongyao Wu et al.
Chengqi Peng et al.
The gastrointestinal tract constitutes the principal anatomical interface of the microbiota-gut-brain axis (MGBA), orchestrating neuroimmune and metabolic crosstalk. Dysregulation within this network drives neurodegenerative pathogenesis th...
Blockade of the SP/NK1 receptor axis: multimodal neuroprotection via inflammatory suppression, hypoxic modulation, and lympho-vascular remodeling in global cerebral ischemia [0.03%]
SP/NK1受体轴的阻断：通过抑制炎症、调节缺氧及淋巴和血管重塑对全脑缺血产生多模式神经保护作用
Mehmet Öz,Erdem Arslan
Mehmet Öz
Transient global cerebral ischemia (tGCI), often precipitated by cardiac arrest, triggers severe neuroinflammation, oxidative stress, and hypoxia, culminating in diffuse delayed neuronal death and debilitating cognitive-affective dysfunctio...
T3 and curcumin regulates collagen-IV and collagen-VI expression: role in suppression of amyloid-β via TGFβ1-Sp1 signaling in hypothyroid mice brain [0.03%]
T3和姜黄素调节IV型和VI型胶原蛋白表达：通过TGFβ1-Sp1信号通路抑制低甲状腺素小鼠脑部淀粉样蛋白-β的作用机制研究
Sulata Kumari Sahu,Madhusmita Nayak,Achyutananda Samal et al.
Sulata Kumari Sahu et al.
Hypothyroidism has been associated with cognitive disorders and high risk of neurodegenerative disorders like Alzheimer's disease (AD), which is caused by amyloid-β (Aβ) accumulation in brain. The aim of the study is to examine the therap...
From synaptic development to degeneration: a narrative review of small molecule strategies targeting alpha-synuclein in Parkinson's disease [0.03%]
从突触核蛋白发育到变性：针对帕金森病中小分子作用于α-突触核蛋白的综述研究
Leanne Khoo,Khuen Yen Ng,Cien Leong Chye et al.
Leanne Khoo et al.
Aggregation of α-synuclein (α-Syn) is a defining pathological feature of Parkinson's disease (PD), contributing to progressive neuronal dysfunction and death. Unlike prior reviews focused predominantly on aggregation as an isolated endpoi...
Pentoxifylline targets TLR4/MyD88/NF-κB signaling to ameliorate neuroinflammation and metabolic dysfunction in a rat model of chronic hypoperfusion-induced vascular cognitive impairment [0.03%]
培化磷通过靶向TLR4/MyD88/NF-κB信号通路改善慢性低灌注血管性认知障碍大鼠模型的神经炎症及代谢功能异常
Xiaohan Wang,Bingchuan Xie,Xiaoyang Yuan et al.
Xiaohan Wang et al.
Vascular cognitive impairment (VCI) driven by chronic cerebral hypoperfusion lacks disease-modifying therapy. We tested whether pentoxifylline (PTX), a methylxanthine phosphodiesterase inhibitor with dual hemorheological and anti-inflammato...
Metabolomic insights into migraine: mechanisms and biomarkers from in vivo and clinical studies [0.03%]
代谢组学视角下的偏头痛：来自体内和临床研究的机制和生物标志物
Wattakorn Laohapiboolrattana,Nipon Chattipakorn,Siriporn C Chattipakorn
Wattakorn Laohapiboolrattana
Migraine is a complex neurological disorder characterized by recurrent attacks of moderate to severe headaches with nausea, photophobia, and phonophobia. Although advances in neuroimaging have improved diagnostic capabilities and options of...
Seipin modulates Alzheimer's disease pathogenesis by regulating ferroptosis through a glycine-mediated metabolic pathway [0.03%]
丝蛋白通过甘氨酸介导的代谢途径调节铁死亡从而调控阿尔茨海默病病理过程
Xiaoqiong An,Daoju Wu,Yijia Wang et al.
Xiaoqiong An et al.
Alzheimer's disease (AD) remains an incurable neurodegenerative disorder with an elusive pathogenesis, where emerging evidence implicates metabolic dysregulation and ferroptosis in neuronal loss. Although the BSCL2 gene, which encodes Seipi...
Association between COVID-19 infection, elevated C-reactive protein, and neuropsychiatric symptoms in individuals with metabolic and cardiovascular comorbidities [0.03%]
新型冠状病毒感染、C-反应蛋白升高及代谢和心血管合并症患者的神经精神症状之间的关联研究
Gabriel S Mondo,Lucas C Pedro,Camila O Arent et al.
Gabriel S Mondo et al.
Elevated serum inflammatory markers are associated with neuropsychiatric symptoms. This process is potentially more intense in individuals with chronic comorbidities such as obesity, systemic arterial hypertension (SAH), and diabetes mellit...
Neural network-enhanced investigation of ferroptosis and druggability in early-onset alzheimer's disease [0.03%]
神经网络增强的早期发作性阿尔茨海默病铁死亡及药物靶点研究
Pratibha Singh,Soumya Lipsa Rath
Pratibha Singh
Alzheimer's disease (AD) is a complex neurodegenerative disorder which is multifactorial in nature. Some of its characteristics are slow cognitive decline, memory problems and behavioral changes. AD patient brains show a progressive synapti...