Retraction Note: MiR-337-3p confers protective effect on facet joint osteoarthritis by targeting SKP2 to inhibit DUSP1 ubiquitination and inactivate MAPK pathway [0.03%]
撤回 notice:MiR-337-3p通过靶向SKP2抑制DUSP1泛素化和抑制MAPK途径对椎间盘关节骨关节炎产生保护作用
Shengsheng Jian,Dixin Luo,Yeyang Wang et al.
Shengsheng Jian et al.
Mechanisms of synergistic action between olaparib and KPT-330 in pancreatic cancer [0.03%]
奥拉帕利联合KPT-330在胰腺癌中协同作用机制研究
Yuntao Yang,Yuying Zhang,Yajing Zhang et al.
Yuntao Yang et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and prognostically poor cancer driven by multifaceted mechanisms, notably immune evasion and drug resistance. The majority of PDAC patients presen...
UBE2C at the crossroads of cell cycle regulation and DNA damage response in cancer [0.03%]
细胞周期调控和DNA损伤反应在癌症中的交汇点UBE2C
Sayandrila Paul,Amoolya Kandettu,Sanjiban Chakrabarty
Sayandrila Paul
The ubiquitin-proteasome system (UPS) is an important regulator of numerous cellular pathways, including DNA repair, protein degradation, the cell cycle, and signal transduction. UBE2C, a member of the ubiquitin-conjugating enzyme family, f...
The functions, mechanisms and clinical relevance of RNA and protein acetyltransferase NAT10: a comprehensive review [0.03%]
NAT10核苷酸转移酶的功能、机制及其临床意义：综述
Chengyu Zhang,Jinmeng Lu,Lu Tang et al.
Chengyu Zhang et al.
The rapid advances in epigenetic and epitranscriptomic regulatory mechanisms have opened new prospects for precision therapies in various diseases. N-acetyltransferase 10 (NAT10) is currently the only known eukaryotic RNA ac4C acetyltransfe...
PIK3CB depletion restores immunosurveillance and enhances radioactive iodine response in hepatocellular carcinoma [0.03%]
PIK3CB丢失恢复了肝细胞癌的免疫监视并增强放射性碘的反应
Yuanren Gao,A Rouhan,Wenbo Wang et al.
Yuanren Gao et al.
Hepatocellular carcinoma (HCC) has a high incidence and mortality rate despite the existence of various treatments, including iodine-125 (125I) seed implantation. Nevertheless, resistance to these treatments persists as a challenge. Here, w...
Lactylation-driven stabilization of the S100A11/ANXA2 complex promotes pancreatic cancer metastasis [0.03%]
乳酰化驱动的S100A11 / ANXA2复合物稳定促进胰腺癌转移
Bo Zheng,Lijun Cai,Ying Deng et al.
Bo Zheng et al.
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a pronounced Warburg effect and high lactate levels. While lysine lactylation (Kla) is an emerging post-translational modification, its role in regulating the S100A11/ANXA2 complex...
Co-exposure to polystyrene nanoparticles and tetrabromobisphenol A induces genotoxicity and interferes with intestinal barrier differentiation [0.03%]
聚苯乙烯纳米粒子和四溴双酚A的共暴露诱导遗传毒性并干扰肠屏障分化
Patricia Soto-Bielicka,Soledad Sanz-Alférez,M José Hazen et al.
Patricia Soto-Bielicka et al.
Tetrabromobisphenol A (TBBPA) and polystyrene nanoparticles (PSNPs) are contaminants of emerging concern frequently detected in environmental matrices, with dietary exposure representing a major route. Despite their co-occurrence, data on c...
MANF safeguards mitochondria-associated endoplasmic reticulum membrane integrity in nucleus pulposus-derived mesenchymal stem cells to maintain homeostasis of the intervertebral disc [0.03%]
线粒体相关内质网膜结构完整性的保护在维持椎间盘稳态中发挥重要作用
Chenhao Zhao,Liang Kang,Jiaqi Wang et al.
Chenhao Zhao et al.
Background: Intervertebral disc (IVD) degeneration (IDD) is a leading cause of low back pain, with limited treatment options. The degenerative disc's harsh microenvironment promotes nucleus pulposus-derived mesenchymal st...
MAP4K4 inhibition enhances the anti-ferroptosis effect of the FTO/YAP/ATF4 axis in doxorubicin-induced cardiotoxicity [0.03%]
MAP4K4抑制通过FTO/YAP/ATF4轴增强多柔比星诱导的心脏毒性抗铁死亡效应
Youyou Yan,Dandan Song,Longbo Li et al.
Youyou Yan et al.
Background: Doxorubicin (DOX) is a highly effective chemotherapeutic agent, but its clinical application was constrained by irreversible cardiotoxicity. Increasing evidence indicates that ferroptosis is a central mechanis...
The application progress of organoid technology in the toxicity assessment of environmental pollutants [0.03%]
类器官技术在环境毒理学评价中应用进展
Guojie Zhao,Yishuang Cui,Hongjiao Wu et al.
Guojie Zhao et al.
Human production activities and daily life are the main sources of environmental pollutants, and their potential health impacts have attracted growing attention. Currently, the assessment of environmental pollutant toxicity depends heavily ...