Distinct mechanisms of cell in breast cancer and their clinical implication [0.03%]
乳腺癌中的不同细胞间相互作用及其临床意义
Aodi Li,Sishi Liu,Ying Xuan et al.
Aodi Li et al.
Breast cancer is a heterogeneous disease affecting women globally. Despite significant advancements in therapeutic interventions in recent years, breast cancer remains a leading cause of cancer-related morbidity in women. Breast cancer's di...
Protein crotonylation in cancer: mechanisms, functions, and therapeutic potential [0.03%]
蛋白质克罗 tonylation在癌症中的机制、功能及治疗潜力
Feng Han,Wandi Shen,Xiaotong Zhang et al.
Feng Han et al.
Lysine crotonylation (Kcr) has recently emerged as a distinctive post-translational modification with unique structural features and regulatory functions. Since its discovery in 2011, more than 10,000 histone and non-histone crotonylation s...
The role of FIS1 and its post-translational modifications in diseases and health damage caused by environmental pollution [0.03%]
FIS1及其翻译后修饰在环境污染导致的疾病和健康损伤中的作用
Lingyu Qin,Pinya Liu,Shuhua Xi
Lingyu Qin
Mitochondrial fission protein 1 (FIS1) is present in the cytoplasm and can be transported to the outer mitochondrial membrane. It can interact with DRP1 (Dynamin-Related Protein 1) to mediate mitochondrial fission and fusion, and most of th...
UBC9 mediates mitophagy to attenuate oxidative stress by regulating SUMOylation of PINK1 in the Parkinson's disease progression [0.03%]
UBC9通过调节PINK1的SUMO化介导线粒体自噬来缓解帕金森病进程中的氧化应激
Jian Liu,Ge Jia,Yu Zhou et al.
Jian Liu et al.
Background: Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive loss of dopaminergic neurons. UBC9 is related to the formation of several cancers. Nevertheless, the function of UBC9 in PD ...
Multifunctional nanoplatforms for optic nerve regeneration integrating anti-inflammatory, epigenetic, and ionic mechanisms with emerging artificial intelligence technologies [0.03%]
集抗炎、表观遗传和离子机制于一体的新兴人工智能技术的多功能纳米平台在optic神经再生中的应用研究
Tian Wang,Shan Huang,Jiayi Wu et al.
Tian Wang et al.
Optic nerve injury represents a common pathological basis underlying various blinding diseases and remains without effective regenerative therapies. The review focuses on three key mechanisms: the inflammatory microenvironment, epigenetic d...
DAZAP1 promotes cancer progression and chemotherapy resistance by stabilizing PIN1 protein in gastric cancer [0.03%]
DAZAP1通过稳定PIN1蛋白促进胃癌进展和化疗耐药性
Peiling Zhang,Lujuan Ma,Yitian Wei et al.
Peiling Zhang et al.
Gastric cancer (GC) continues to be a fatal disease globally, largely due to the lack of dependable molecular indicators enabling early diagnosis and therapeutic intervention. Single-cell transcriptomic analysis revealed significant enrichm...
Exploring potential targets and molecular mechanisms of traumatic brain injury exacerbated by Benzo(a)pyrene via network toxicology and molecular dynamics simulation [0.03%]
基于网络毒理学和分子动力学模拟的苯并(a)芘加重创伤性脑损伤潜在靶点及分子机制研究
Hantian Hu,Yuetao Hu,Siqi Wan et al.
Hantian Hu et al.
Benzo(a)pyrene (BaP) is a common environmental pollutant from combustion sources that promotes oxidative stress, neuroinflammation and disruption of blood-brain barrier (BBB). However, its contribution to worsening traumatic brain injury (T...
Dual-functional Mo₂N nanomaterials for photothermal therapy: enhancing MRSA-infected wound healing and selective thyroid cancer ablation [0.03%]
用于光热治疗的双功能二钼化氮纳米材料：增强MRSA感染伤口愈合及选择性甲状腺癌消融
Wei Zhang,Shixi Wu,Chengze Chen
Wei Zhang
Thyroid cancer treatment and bacterial infection management have long been challenging due to the limited effectiveness and side effects of conventional therapies. Here, we introduce molybdenum nitride (Mo₂N) nanomaterials as an innovative...
Molecular mechanisms in diquat-induced organs injury：insights into cell signaling and potential therapeutic agents [0.03%]
灭多威诱导的器官损伤分子机制：细胞信号转导及潜在治疗药物研究新进展
Siying Han,Dan Dong,Zhenning Liu
Siying Han
Diquat (DQ) is a potent, non-selective herbicide which can result in severe poisoning and a high mortality if ingested accidentally or intentionally. Diquat poisoning can cause extensive damage to multiple organs, including the intestines, ...
Copper-cysteamine nanoparticles in cancer treatment: a systematic review [0.03%]
癌症治疗中的铜-半胱胺纳米颗粒：系统性综述
Mahsa Ejtema,Nahid Chegeni,Britta Langen et al.
Mahsa Ejtema et al.
Copper-cysteamine nanoparticles (Cu-Cy NPs) represent an innovative approach for cancer therapy due to their unique ability to be activated by multiple physical and chemical stimuli. This review systematically evaluates studies investigatin...