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Lactylation-driven stabilization of the S100A11/ANXA2 complex promotes pancreatic cancer metastasis

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Pancreatic ductal adenocarcinoma (PDAC) is characterized by a pronounced Warburg effect and high lactate levels. While lysine lactylation (Kla) is an emerging post-translational modification, its role in regulating the S100A11/ANXA2 complex-a critical driver o... ...