GM1 oligosaccharide-mediated rescue in GBA-linked Parkinson's disease via modulation of lysosomal and mitochondrial dysfunctions [0.03%]
通过调节溶酶体和线粒体功能异常介导的GBA基因相关帕金森病中GM1寡糖的救援作用
Giulia Lunghi,Carola Pedroli,Ilaria Tagliabue et al.
Giulia Lunghi et al.
Mutations in the glucocerebrosidase GBA gene, encoding the lysosomal enzyme β-glucocerebrosidase, represent the most frequent genetic risk factor for Parkinson's disease, leading to lysosomal dysfunction, α-synuclein aggregation, and mito...
Anti-GalNAcα (anti-Tn) antibody repertoire differs between individuals with blood groups A and B [0.03%]
A型和B型血人群中的抗GalNAcα（抗Tn）抗体谱不同
Polina Obukhova,Nadezhda Shilova,Galina Pazynina et al.
Polina Obukhova et al.
Recently, Breiman et al. (2021) reported that the level of anti-Tn in the blood of healthy donors and COVID-19 patients is significantly lower in individuals of blood group A than B. This prompted us to look for qualitative differences in t...
Exploring the impact of advanced glycation end products on diabetic salivary gland dysfunctions [0.03%]
探讨晚期糖基化终产物对糖尿病患者唾液腺功能障碍的影响
Heba A Hassan
Heba A Hassan
The role of Advanced Glycation End Products (AGEs) in the pathophysiology of salivary gland dysfunction in diabetes has not been fully addressed. In this work, we discuss the pathophysiological mechanisms of salivary gland dysfunctions in d...
Substrate flexibility of Mycoplasma fermentans mf1 phosphorylcholine transferase [0.03%]
发酵支原体mf1磷酸胆碱转移酶的底物柔性
Lena Nuschy,Biswajit Sarkar,Alla Zamyatina et al.
Lena Nuschy et al.
Zwitterionic modifications of glycans such as phosphorylcholine or phosphoethanolamine occur in a wide range of prokaryotic and eukaryotic organisms and are known for interaction with the mammalian immune system. Unlike the biosynthesis of ...
Cartilaginous fishes-derived chondroitin sulfates potentially suppress lipid droplet accumulation in the differentiated 3T3-L1 adipocytes [0.03%]
软骨鱼来源的硫酸软骨素有可能抑制分化后的3T3-L1脂肪细胞中的脂滴积聚
Danang Dwi Cahyadi,Katsuhiko Warita,Naoko Takeda-Okuda et al.
Danang Dwi Cahyadi et al.
In this study, we investigated for cell proliferative and adipogenic differentiation inhibitory activities of chondroitin sulfate (CS) from cartilaginous fish: mako shark (Isurus oxyrinchus, spine part, Ms-CS), blue shark (Prionace glauca, ...
Plant glycosides and glycosidases: classification, sources, and therapeutic insights in current medicine [0.03%]
植物糖苷和糖苷酶：分类、来源以及在现代医学中的治疗见解
Kumaresan Kowsalya,Nandakumar Vidya,Jayachandran Halka et al.
Kumaresan Kowsalya et al.
Plant glycosides have a broad spectrum of pharmaceutical activities primarily due to the glycosidic residues present in their structure. Especially, the therapeutic glycosides can be classified into many compounds based on the sugar moiety,...
Computational insights into DC-SIGN's enhanced recognition of mannotriose CPS units via Ca2+ ion cross-talk [0.03%]
通过Ca2+离子串扰增强DC-SIGN对万乃洛糖CPS单元识别的计算见解
Hemchandra Deka,Arabinda Ghosh,Debabrat Baishya
Hemchandra Deka
The Carbohydrate Recognition Domain (CRD) of immune system's c-type lectin receptors (CLRs) preferentially interacts with the Capsular Polysaccharides (CPS) units. Implicit Ca2+ ions are crucial to CRD function. Increment of the ionic conce...
Mechanistic studies of chondroitin sulfate/dermatan sulfate isolated from freshwater fish discards on osteogenesis in MC3T3-E1 cells [0.03%]
淡水鱼废弃物中硫酸软骨素/皮肤硫酸软骨素的成骨作用机制研究
Chandra Gavva,Kunal Sharan,Nandini Chilkunda
Chandra Gavva
Glycosaminoglycans (GAGs) are essential bone extracellular matrix molecules that regulate osteoblast differentiation. Numerous studies have explored endogenous and exogenous GAG osteoanabolic activities using appropriate in vitro and in viv...
Spatial single-cell maps reveal ST6GAL1 promoting ovarian cancer metastasis [0.03%]
空间单细胞图谱揭示ST6GAL1促进卵巢癌转移
Lan-Hui Qin,Zijian Jiang,Chongze Yang et al.
Lan-Hui Qin et al.
In this study, spatial and single-cell transcriptome techniques were used to investigate the role of beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) in promoting peritoneal metastasis in ovarian cancer epithelial cells. We collecte...
Inhibition of chondroitin sulphate-degrading enzyme Chondroitinase ABC by dextran sulphate [0.03%]
硫酸右旋糖抑制硫酸软骨素降解酶软骨素酶ABC的作用
Sagar Dalal,Rachana Pathak,Edward X S Moh et al.
Sagar Dalal et al.
Chondroitin sulphate (CS) is a sulphated glycosaminoglycan (GAG) polysaccharide found on proteoglycans (CSPGs) in extracellular and pericellular matrices. Chondroitinase ABC (CSase ABC) derived from Proteus vulgaris is an enzyme that has ga...