Structural dynamics and stability analysis of a novel ARSK variant confirms its role in MPS type X pathogenesis [0.03%]
一种新型ARSK变异体的结构动力学与稳定性分析证实其在MPS型X发病机制中的作用
Muhammad Bilal,Muhammad Fakhar,Thamir Eid et al.
Muhammad Bilal et al.
Mucopolysaccharidoses (MPS) are heterogeneous group of disorders caused by the deficiency of lysosomal enzymatic activities. Deficiencies in these enzymes are required for proper degradation of glycosaminoglycans (GAGs), thus referred as in...
Homo-oligomeric forms of lectins: their structural insights for glycan binding from the genus Canavalia [0.03%]
镜质体的同寡聚形式：来自Canavalia属的凝集素结合糖类的结构见解
Mahi Dev Ayikkara Peroor,Nivetha Ramanathan,Meenakumari Mani et al.
Mahi Dev Ayikkara Peroor et al.
Lectins are made with identical polypeptide subunits as homo-oligomers in various species of Canavalia. Their interaction with the structures of specific glycans is influenced greatly when many identical polypeptides are cooperatively invol...
Correction to: Alpha-Gal syndrome unveiled: decoding the glycan-driven red meat allergy [0.03%]
alpha-gal综合征的发现：解码驱动红肉过敏的糖链分子
Łukasz F Sobala,Katarzyna Szymczak-Kulus,Łukasz Kasper et al.
Łukasz F Sobala et al.
Published Erratum
Glycoconjugate journal. 2026 Jul 3;43(1):25. DOI:10.1007/s10719-026-10224-2 2026
Mechanistic and functional integration of sirtuin deacylases: from substrate specificity to biological outcomes [0.03%]
Sirtuin脱乙酰酶的机理及功能整合：从底物特异性到生物学效应
Jian-Long Zhang,Zi-Yu Dou,Yong-Yue Fan et al.
Jian-Long Zhang et al.
Sirtuins, as classic NAD⁺-dependent class III histone deacetylases (HDACs), have been the focus of extensive research since their discovery, primarily centered on the mechanisms by which their deacetylase activity mediates the pathogenesis...
Macrophage modulation accounts for the anti-inflammatory effect of Hypnea cervicornis agglutinin in rat arthritis induced by zymosan [0.03%]
霍索孢裸枝藻凝集素通过调节巨噬细胞产生抗炎作用并减轻芽生菌诱导的大鼠关节炎症状
Francisco Glerison da Silva Nascimento,Pedro Henrique de Souza Ferreira Bringel,Diego Freitas de Araujo et al.
Francisco Glerison da Silva Nascimento et al.
Previous study demonstrated that Hypnea cervicornis lectin (HCA) reduces inflammation and nociception via interaction with the lectin carbohydrate-binding site, modulating gene expression of the interleukins IL-1β, TNF-α and of iNOS. This...
Nucleolar-localized sialidase Neu4 suppresses cell proliferation through destabilizing c-Myc via interacting with ribosomal proteins L5 and L11 [0.03%]
定位于核仁的唾液酸酶Neu4通过与核糖体蛋白L5和L11相互作用降解c-Myc抑制细胞增殖
Toshiki Hyodo,Satsuki Yamate,Xiaoying Chen et al.
Toshiki Hyodo et al.
Sialidase Neu4 is a glycosidase that removes sialic acids from nonreducing ends of sugar chains. Recently, Mexican tetra Neu4 (AmNeu4) was identified as a nuclear-localized sialidase. However, the subnuclear localization and biological func...
3'-sialyllactose inhibits the migration and invasion of LPS-induced B16F10 mouse melanoma cells through inactivation of the NF-KB signaling pathway [0.03%]
3-唾液乳糖通过NF-κB信号通路失活抑制LPS诱导的B16F10小鼠黑色素瘤细胞迁移和侵袭
Hee-Do Kim,Hyunju-Choi,Yu-Chan Chang et al.
Hee-Do Kim et al.
Malignant melanoma has a high mortality rate and is aggressive. The development, metastasis, and angiogenesis of melanoma have all been connected to toll-like receptor 4 (TLR4). However, signal transduction mediated by TLR4 for accelerating...
Mechanism analysis of transgene expression induced by chitosan/hyaluronic acid nanoparticles in CD44v9/RHAMM co-expressed gastric cancer cells: contribution of hyaluronic acid to RHAMM-mediated intracellular transport [0.03%]
壳聚糖/透明质酸纳米粒诱导CD44v9/RHAMM共表达胃癌细胞转基因表达机制研究：透明质酸对RHAMM介导的胞内转运的作用
Yu Torizuka,Shogo Nakamura,Hitoshi Tsugawa et al.
Yu Torizuka et al.
Optimizing non-viral vectors for gene therapy requires elucidating the molecular mechanisms underlying vector uptake and intracellular delivery. In this study, cell transfection using pDNA/polysaccharide complexes was investigated to develo...
Alpha-Gal syndrome unveiled: decoding the glycan-driven red meat allergy [0.03%]
揭开α半乳糖综合征的面纱：解读糖链驱动的红肉过敏反应
Łukasz F Sobala,Katarzyna Szymczak-Kulus,Łukasz Kasper et al.
Łukasz F Sobala et al.
α-Gal syndrome (AGS) is a type of allergy to red meat and other mammalian products that develops after a tick bite. Symptoms may include urticaria, angioedema, gastrointestinal and respiratory symptoms, and, most dangerously, anaphylactic ...
Conceptual and Mechanistic Links between glycated hemoglobin and glycosylated RNA: An insight into glycosylation biology in metabolic disease pathophysiology [0.03%]
糖基化终产物导致RNA糖基化的概念和机制联系：代谢性疾病发病机理中糖基化生物学的见解
Peter Chinedu Agu,Patrick Maduabuchi Aja,Boniface Anthony Ale et al.
Peter Chinedu Agu et al.
Glycated hemoglobin (HbA1c) is a well-established biomarker reflecting chronic glycemic control in diabetes. It accumulates through non-enzymatic glycation of hemoglobin under sustained hyperglycemia and serves as a surrogate of metabolic m...