Loss of Peroxisomal Membrane Proteins PEX13 and PEX14 Disrupts Fatty Acid Oxidation and Drives Lipid Imbalance [0.03%]
过氧化物酶体膜蛋白PEX13和PEX14丢失破坏脂肪酸氧化并导致脂质稳态失衡
Navia Vinoy,Gary Huang,Daniel Wallace et al.
Navia Vinoy et al.
Peroxisomal disorders arise from severe peroxisome dysfunction and are frequently linked to liver pathology. Metabolic dysfunction-associated steatotic liver disease, which affects up to 38% of adults worldwide, has driven extensive efforts...
Serum-Free Culture with PVP Enables Maintenance of Primary Culture of Parathyroid Cells In Vitro [0.03%]
聚乙烯吡咯烷酮无血清培养能使甲状旁腺原代培养体外长期存活
Natsumi Iwawaki,Toshiyuki Takehara PhD,Atsuhiro Tatemizo et al.
Natsumi Iwawaki et al.
The parathyroid gland is a critical endocrine organ responsible for maintaining serum calcium homeostasis through the secretion of parathyroid hormone (Pth). Parathyroid tissue can be irreversibly lost due to autoimmune diseases or surgical...
Using a bioluminescence resonance energy transfer (BRET2) caspase biosensor to study caspase-3 cleavage site specificity [0.03%]
利用生物发光共振能量转移(CRET)半胱天冬酶生物传感器研究caspase-3的切割位点特异性
Véronique Blais,Jean-Bernard Denault
Véronique Blais
In its simplest representation, apoptosis is a two-step peptidase cascade in which initiator caspases (caspases-8, -9, and -10) activate executioner caspases (caspases-3, -6, and -7). Although many intricacies exist-such as the proteolysis ...
Differential glucose uptake response to IGF-II and vesiculin in insulin resistant muscle and adipose cells [0.03%]
IGF-II和vesiculin在胰岛素抵抗的肌肉细胞和脂肪细胞中产生的不同的葡萄糖摄取反应
Thai Nguyen,Caren Leemberg,Kate L Lee
Thai Nguyen
Type 2 diabetes (T2D), a significant global health concern, is characterized by insulin resistance and progressive pancreatic β-cell degradation leading to failure of blood glucose regulation. Pancreatic islet hormones are essential for sy...
Isoprenaline Alleviates Diabetic Kidney Disease via Multi-Target Inhibition of the cGAS-STING Pathway [0.03%]
异丙肾上腺素通过多靶标抑制cGAS-STING通路缓解糖尿病肾脏疾病
Runtao Ma,Yue Song,Lijun Zhang et al.
Runtao Ma et al.
Diabetic kidney disease (DKD) is a common microvascular complication of diabetes and is closely linked to chronic inflammation. This study examined how the β-adrenergic receptor agonist isoprenaline (ISO) protected against DKD by regulatin...
Johnathan E LeSaint PhD,Daniel J Peter,Huimei Wei PhD et al.
Johnathan E LeSaint PhD et al.
Aldicarb is a carbamate pesticide used for pest control in agriculture. As a fast-acting acetylcholinesterase inhibitor, aldicarb interferes with the nervous system by preventing the breakdown of acetylcholine. Aldicarb could be used as a c...
Bekir C Celikkaya,Fraser J Scott
Bekir C Celikkaya
Restriction endonucleases (REs) are sequence-specific DNA-cleaving enzymes that are widely used as tools in molecular biology. Although REs is not typically considered therapeutic targets, their inhibition provides a useful framework for un...
The role of growth hormone in metastasis and angiogenesis of breast cancer [0.03%]
生长激素在乳腺癌转移和血管生成中的作用
Tamanna Alam,Mingyang Hu,Rivka L Isaacson
Tamanna Alam
Breast cancer is a complex disease which has many factors affecting its progression and metastasis. Although steroid hormones, especially oestrogen, are most commonly associated with breast cancer, growth hormone (GH) also plays a substanti...
Aminolevulinate Inhibition of Human Coproporphyrinogen Oxidase clarifies Coproporphyrin III Accumulation in Porphyrias [0.03%]
氨基酮戊酸抑制人类粪卟啉原氧化酶可解释卟啉病中粪卟啉III的累积现象
Andreas Schedlbauer,Sarah Kratzwald,Margarita Gómez-Galán et al.
Andreas Schedlbauer et al.
Porphyrias are inherited or acquired disorders of heme biosynthesis characterized by heme deficiency and accumulation of toxic intermediates. In δ-aminolevulinic acid dehydratase deficiency porphyria (ALADP), patients consistently present ...
Modulating Galectin-1 in human osteoblast-like cells alters mineralisation and influences the expression of genes associated with osteoblasts and osteocytes [0.03%]
人成骨样细胞中半乳糖凝集素-1的调节改变矿化并影响与成骨细胞和成骨细胞相关基因的表达
Amy Ross,Lauren Feddersen,Jayesh Dudhia et al.
Amy Ross et al.
Bone formation, mineralization and remodelling is dependent on the activity of osteoblasts and osteoclasts. While many genes support bone development, their specific functions in the different stages of cell differentiation and maturation a...