Using a bioluminescence resonance energy transfer (BRET2) caspase biosensor to study caspase-3 cleavage site specificity
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In its simplest representation, apoptosis is a two-step peptidase cascade in which initiator caspases (caspases-8, -9, and -10) activate executioner caspases (caspases-3, -6, and -7). Although many intricacies exist-such as the proteolysis of initiator caspase... ...
