Structural characterization of the human CC2D1A fragment associated with non-syndromic intellectual disability (NSID) [0.03%]
Yi-Hung Yeh,Min-Guan Lin,Xing-Han Sun et al.
Yi-Hung Yeh et al.
CC2D1A is a multidomain scaffold protein implicated in transcriptional regulation and autosomal recessive non-syndromic intellectual disability (NSID), yet its molecular mechanism is still poorly understood due to a lack of structural infor...
Conserved rod-to-spherical shape transitions in Escherichia coli through primordial experimental adaptations [0.03%]
Hui Lu,Yueyue Zhang,Boying Xu et al.
Hui Lu et al.
Cell shape plays a fundamental role in bacterial physiology, yet the evolutionary stability of morphological adaptations remains poorly understood. Our previous work suggested that Escherichia coli can evolve a spherical form under primordi...
Yonika A Larasati,Alexey Koval,Vladimir L Katanaev
Yonika A Larasati
GNAO1-related neurodevelopmental disorders are caused by mutations in the GNAO1 gene encoding the major neuronal G protein, Gαo. GNAO1 encephalopathies manifest in a range of symptoms, including epilepsy, movement disorder, hypotonia, and ...
Aerobic Exercise Is Associated with Divergent Regulation of Macrophage Migration Inhibitory Factor and Enhanced Remyelination in Experimental Autoimmune Neuritis [0.03%]
Yantong Liu,Xiaohan Shi,Ying Wang et al.
Yantong Liu et al.
This study investigated the association between aerobic exercise preconditioning and macrophage migration inhibitory factor (MIF) expression, as well as myelination in sciatic nerve in experimental autoimmune neuritis (EAN) rats. Female Lew...
Effects of Low-Dose Lithium Supplementation on Thermal Inactivation of SERCA in Cardiac Muscle of Male Mice [0.03%]
Sophie I Hamstra,Mia S Geromella,Panagiota Klentrou et al.
Sophie I Hamstra et al.
The sarco(endo)plasmic reticulum calcium (Ca2+)-ATPase 2 (SERCA2) is a crucial regulator of cardiac muscle function that is sensitive to changes in the cellular environment, such as increased oxidative stress. This can be observed in heat s...
Engineering extracellular vesicles for targeted therapeutic delivery in the heart [0.03%]
工程化细胞外囊泡实现心脏靶向治疗递送
Iqra Anwar,Xinghua Wang,Saverio Parlongo et al.
Iqra Anwar et al.
Heart failure is a leading cause of morbidity and mortality, highlighting the need for improved therapeutic strategies. Critical to the success of therapies is efficient and targeted delivery systems. Extracellular vesicle-based delivery sy...
A systematic review and meta-analysis of shRNA-IL-6-engineered CAR-T cells for B-cell Acute Lymphoblastic Leukemia: a stepping stone towards risk-free immunotherapy [0.03%]
用于治疗B细胞急性淋巴细胞白血病的shRNA-IL-6工程化CAR-T细胞的系统评价和荟萃分析：迈向风险免费免疫治疗的第一步
Mohamed S Attia,Brett Dyer,Nigel McMillan et al.
Mohamed S Attia et al.
Clinical application of chimeric antigen receptor (CAR)-T cells, especially those targeting CD19, stands as a breakthrough in treating relapsed or refractory B-cell acute lymphoblastic leukemia (r/r B-ALL). Yet, preventing immune-related ad...
Redox status of apolipoprotein E in cerebrospinal fluid: A mechanistically informative biomarker for central nervous system disorders [0.03%]
脑脊液中载脂蛋白E的氧化还原状态：中枢神经系统疾病的机制性生物标志物
Yui Uematsu,Wakana Iinuma,Riho Shimizu et al.
Yui Uematsu et al.
Apolipoprotein (apo) E is the major cholesterol carrier in the central nervous system (CNS); however, the clinical relevance of its cysteine-thiol redox status in cerebrospinal fluid (CSF) remains unclear. We investigated whether CSF apoE r...
Patients-derived AMOTL1 mutations lead to defective cell migration and tissue development [0.03%]
AMOTL1基因突变导致细胞迁移和组织发育缺陷
Jiaqian Luo,Ruxin Jin,Fang Geng et al.
Jiaqian Luo et al.
Angiomotin-like 1 (AMOTL1), by regulating cell-cell junctions, cell polarity, and cell migration, plays a critical role in organogenesis and development. Recently, multiple studies have identified two hotspot mutations in AMOTL1, Arg157 (R1...
Wanderley de Souza,Ana Paula Gadelha,Marlene Benchimol
Wanderley de Souza
The cytoskeleton is a key component of eukaryotic cells, including protists. It is composed of microtubules, microfilaments, and intermediate filaments. Here, we review the available information on the cytoskeleton of several relevant patho...