Basic-patch mutations in bacteriophage T4 Rad50 uncouple ATPase activation from processive nuclease activity [0.03%]
T4 Rad50噬菌体中基本补丁突变将ATP酶激活与连续核酸酶活性解偶联
Tibebe A Teklemariam,Ryan M Finnerty,Jennifer B Coats et al.
Tibebe A Teklemariam et al.
The Mre11/Rad50 (MR) complex uses ATP binding and hydrolysis to coordinate the recognition and processing of DNA double-strand breaks. Although Mre11 and DNA stimulate the relatively slow ATPase activity of Rad50, the mechanism by which thi...
Bacterial heteroresistance mechanisms, dynamics, and emerging diagnostic approaches [0.03%]
细菌异耐药机制、动态及新兴诊断方法
Sophie Brameyer
Sophie Brameyer
Antibiotic heteroresistance is a form of within-isolate susceptibility heterogeneity in which an apparently susceptible bacterial population contains rare subpopulations capable of growth at substantially higher antibiotic concentrations. I...
Expression of Concern: Exosomes derived from circRNA Rtn4-modified BMSCs attenuate TNF-α-induced cytotoxicity and apoptosis in murine MC3T3-E1 cells by sponging miR-146a [0.03%]
表达关注：环状RNA Rtn4衍生的外泌体通过海绵作用miR-146a来减轻TNF-α诱导的MC3T3-E1细胞毒性和凋亡及相应的回复函及相关研究论文的发布版本1.0版本的通知
Guijun Cao,Xianqing Meng,Xiaodong Han et al.
Guijun Cao et al.
Evaluation of correlations between serum and urinary vitamin D metabolites using LC-MS/MS [0.03%]
液相色谱-串联质谱法评估血清和尿液中维生素D代谢物的相关性
Shixing Wu,Nau Ishimine,Riho Shimizu et al.
Shixing Wu et al.
Vitamin D (VD) is involved in bone health, immunity, cardiovascular function, and cancer prevention. Recent studies suggested the potential of 24,25-dihydroxyvitamin D3 [24,25(OH)2D3] and the VD metabolite ratio (VMR = [24,25(OH)2D3/25(OH)D...
The evolving therapeutic landscape of gut-pancreatic peptide signalling in metabolic disorders: from mono- to multi-agonist therapies [0.03%]
胃肠胰肽在代谢性疾病治疗中的信号通路演变：从单一激动剂到多激动剂疗法
Marco Falasca,Mohan Patil,Federico Piccinini et al.
Marco Falasca et al.
The pharmacotherapeutic landscape for the clinical management of type-2 diabetes (T2D), obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), and steatohepatitis (MASH) is evolving swiftly in response to the escalating ...
A peripheral blood-based approach involving vimentin along with AURKA enabled efficient tracking of elusive Oct4/Sox2-expressing disseminated breast cancer stem cells [0.03%]
基于外周血并通过Vimentin和AURKA检测伴随Oct4/Sox2表达的狡猾的乳腺癌干细胞的有效方法
Debomita Sengupta,Debanjan Thakur,Elizabeth Mahapatra et al.
Debomita Sengupta et al.
A major impediment in the therapeutic success of breast cancer (BC) arises from persistence of clinically undetectable stem cells (BCSCs) that needs addressal by targeting translationally relevant markers to restrain relapse. Aurora Kinase ...
MCM2-7 proteins promote NF-κB transcriptional activity through cooperative promoter recruitment [0.03%]
MCM2-7蛋白通过协同启动子募集促进NF-κB转录活性
Xian Hong,Ming Sui,Qiang Li et al.
Xian Hong et al.
The minichromosome maintenance 2-7 (MCM2-7) proteins form a hexameric protein complex that is the structural core of replicative helicase, which is essential for accurate DNA replication. While their role in replication is well-established,...
Isabella Folego-Temoteo,Yago C Lima,Eugenio H Grevet et al.
Isabella Folego-Temoteo et al.
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental condition marked by persistent and impairing patterns of inattention, hyperactivity, and impulsivity. Evidence from neurochemical, pharmacological, and genetic research...
Rewiring mTOR signaling in Alzheimer's disease: emerging mTOR modulators beyond oncology [0.03%]
阿兹海默症中mTOR信号通路的重建：来自肿瘤学之外的新的mTOR调节剂
Benedikt Jakob Lohnes,Aneta Myskova,Arti Tyagi et al.
Benedikt Jakob Lohnes et al.
While Alzheimer's disease (AD) is the most common cause of dementia, curative treatments remain unavailable. Despite distinct pathologies between AD and cancer, shared dysregulation of the PI3K-AKT-mTOR signaling pathway promotes both disea...
Diacylglycerol enantiomer selectivity of diacylglycerol acyltransferases highlights metabolic specialization in triacylglycerol synthesis across the tree of life [0.03%]
二酰基甘油对映体选择性二酰基甘油酰基转移酶反映了生命之树中三酰基甘油合成的代谢专一化
Prasad Parchuri,Jay Shockey,Timothy P Durrett et al.
Prasad Parchuri et al.
Triacylglycerols are the major energy storage lipids in plants, animals, and microorganisms, and are predominantly produced by acyl-CoA:diacylglycerol (DAG) acyltransferases (DGATs). Two enantiomers of the DAG substrate, sn-1,2 and sn-2,3, ...