Metabolic reprogramming of the retinal pigment epithelium by cytokines associated with age-related macular degeneration [0.03%]
年龄相关性黄斑变生成熟相关的细胞因子引起的视网膜色素上皮细胞的代谢重构
David S Hansman,Yuefang Ma,Daniel Thomas et al.
David S Hansman et al.
The complex metabolic relationship between the retinal pigment epithelium (RPE) and photoreceptors is essential for maintaining retinal health. Recent evidence indicates the RPE acts as an adjacent lactate sink, suppressing glycolysis in th...
Induced pluripotent stem cells in cartilage tissue engineering: a literature review [0.03%]
软骨组织工程中诱导多能干细胞的研究进展综述
Amani Y Owaidah
Amani Y Owaidah
Osteoarthritis (OA) is a long-term, persistent joint disorder characterized by bone and cartilage degradation, resulting in tightness, pain, and restricted movement. Current attempts in cartilage regeneration are cell-based therapies using ...
Synergistic action of synthetic peptides and amphotericin B causes disruption of the plasma membrane and cell wall in Candida albicans [0.03%]
合成肽与两性霉素B的协同作用可导致白色念珠菌细胞膜和细胞壁损伤
Thayna A M Souza,Erica O Mello,Gabriel B Taveira et al.
Thayna A M Souza et al.
The objective of this work was to evaluate the combination of synthetic peptides based on the γ-core motif of defensin PvD1 with amphotericin B (AmB) at different concentrations against Candida albicans. We applied the checkerboard assay u...
Flow cytometry protocol for GLUT4-myc detection on cell surfaces [0.03%]
用于检测细胞表面GLUT4-myc的流式细胞仪实验方案
Emilia Zanni-Ruiz,Luis Segundo Mayorga,Martin Alejandro Pavarotti
Emilia Zanni-Ruiz
Insulin and muscle contraction trigger GLUT4 translocation to the plasma membrane, which increases glucose uptake by muscle cells. Insulin resistance and Type 2 diabetes are the result of impaired GLUT4 translocation. Quantifying GLUT4 tran...
Enzymatic activity of cGAS in the presence of three types of DNAs: limited cGAS stimulation by single-stranded HIV-1 SL2 DNA [0.03%]
cGAS在三种DNA存在下的酶活性：单链HIV-1SL2 DNA对cGAS的刺激作用有限
Mineyuki Mizuguchi,Niko Kyan,Suzuka Nishimata et al.
Mineyuki Mizuguchi et al.
Cyclic GMP-AMP (cGAMP) synthase (cGAS) is activated by binding to DNA. Activated cGAS produces 2'3'-cGAMP, which subsequently binds to the adaptor protein STING (stimulator of interferon genes). This interaction triggers the cGAS/STING sign...
Retraction: RASA1 inhibits the progression of renal cell carcinoma by decreasing the expression of miR-223-3p and promoting the expression of FBXW7 [0.03%]
撤回：RASA1通过降低miR-223-3p的表达和促进FBXW7的表达来抑制肾细胞癌的发展
Retraction of Publication
Bioscience reports. 2024 Mar 29;44(3):BSR-2019-4143_RET. DOI:10.1042/BSR-2019-4143_RET 2024
Prognostic and clinical significance of tumor-associated macrophages in esophageal squamous cell carcinoma after surgery: do biomarkers and distributions matter? [0.03%]
肿瘤相关巨噬细胞的预后和临床意义：手术后的食管鳞状细胞癌中的生物标志物及分布真的重要吗？
Bin Yi,Jun Zeng,Linfeng Li et al.
Bin Yi et al.
Background: The role of tumor-associated macrophages (TAMs) in patients with esophageal squamous cell carcinoma (ESCC) following surgery remains controversial. Hence, we performed the present study to systematically analy...
The molecular sociology of NHERF1 PDZ proteins controlling renal hormone-regulated phosphate transport [0.03%]
调控肾激素依赖性磷酸盐转运的NHERF1 PDZ蛋白分子社会学研究
Peter A Friedman,Tatyana Mamonova
Peter A Friedman
Parathyroid hormone (PTH) and fibroblast growth factor-23 (FGF23) control extracellular phosphate levels by regulating renal NPT2A-mediated phosphate transport by a process requiring the PDZ scaffold protein NHERF1. NHERF1 possesses two PDZ...
Detection of hepatocellular carcinoma methylation markers in salivary DNA [0.03%]
唾液DNA中肝细胞癌甲基化标志物的检测
Catherine Mezzacappa,Zhanwei Wang,Lingeng Lu et al.
Catherine Mezzacappa et al.
Background: Alterations to DNA methylation have been identified in both hepatocellular carcinoma (HCC) tumor and circulating DNA from affected individuals. These markers have potential utility in HCC screening. Adherence ...