Kenana Al Adem,Juliana C Ferreira,Adrian J Villanueva et al.
Kenana Al Adem et al.
Coronaviruses constitute a significant threat to the human population. Severe acute respiratory syndrome coronavirus-2, SARS-CoV-2, is a highly pathogenic human coronavirus that has caused the coronavirus disease 2019 (COVID-19) pandemic. I...
Tamoxifen metabolites treatment promotes ERα+ transition to triple negative phenotype in vitro, effects of LDL in chemoresistance [0.03%]
他莫昔芬代谢产物诱导ERα阳性乳腺癌上皮细胞向三阴性乳腺癌转化的作用及LDL对其化疗耐药性的影响
Andrea Muñoz-Ayala,Brenda Chimal-Vega,Nicolás Serafín-Higuera et al.
Andrea Muñoz-Ayala et al.
Objective: Estrogen receptor-positive (ER+) breast cancer represents about 80% of cases, tamoxifen is the election neoadjuvant chemotherapy. However, a large percentage of patients develop chemoresistance, compromising re...
Expression, purification and application of a recombinant, membrane permeating version of the light chain of botulinum toxin B [0.03%]
肉毒杆菌素B轻链跨膜型重组表达、纯化及应用
Micaela Vanina Buzzatto,Fabiana Cristina Benegas Guerrero,Pablo Ariel Álvarez et al.
Micaela Vanina Buzzatto et al.
Botulinum neurotoxins (BoNTs) are valuable tools to unveil molecular mechanisms of exocytosis in neuronal and non-neuronal cells due to their peptidase activity on exocytic isoforms of SNARE proteins. They are produced by Clostridia as sing...
Metabolic profiling and combined therapeutic strategies unveil the cytotoxic potential of selenium-chrysin (SeChry) in NSCLC cells [0.03%]
基于系统代谢组学的富硒小分子化合物抗肺癌细胞增殖的作用机制研究
Cindy Mendes,Isabel Lemos,Ana Hipólito et al.
Cindy Mendes et al.
Lung cancer ranks as the predominant cause of cancer-related mortalities on a global scale. Despite progress in therapeutic interventions, encompassing surgical procedures, radiation, chemotherapy, targeted therapies and immunotherapy, the ...
Angela J Glading
Angela J Glading
KRIT1 is a 75 kDa scaffolding protein which regulates endothelial cell phenotype by limiting the response to inflammatory stimuli and maintaining a quiescent and stable endothelial barrier. Loss-of-function mutations in KRIT1 lead to the de...
Low-dose alcohol exacerbates hyperdynamic circulation and shunting in non-alcoholic cirrhotic rats [0.03%]
低剂量酒精可加重非酒精性肝硬化大鼠的高动力循环和分流
Chon Kit Pun,Hui-Chun Huang,Ching-Chih Chang et al.
Chon Kit Pun et al.
Background: Portal hypertension affects hepatic, splanchnic and portosystemic collateral systems. Although alcohol is a well-known risk factor for liver cirrhosis, it also affects vascular contractility. However, the rele...
Functional analysis of a panel of molecular markers for diagnosis of systemic lupus erythematosus in rats [0.03%]
用于诊断大鼠系统性红斑狼疮的一系列分子标记物的功能分析
May A Azzam,Sally A Fahim,Asmaa A ElMonier et al.
May A Azzam et al.
Introduction: Systemic lupus erythematosus (SLE) is a diverse autoimmune disease that arises from a combination of complex genetic factors and environmental influences. While circRNAs and miRNAs have recently been identif...