Integrative Metabolome and Transcriptome Analyses Provide Insights into PHGDH in Colon Cancer Organoids [0.03%]
整合代谢组和转录组分析为结直肠癌类器官中PHGDH提供新见解
Lin Chen,Zhihui Dai,Yanfei Zhang et al.
Lin Chen et al.
As a rate-limiting enzyme in endogenous serine de novo synthesis pathway, PHGDH has been widely concerned about its role in a variety of tumors including colon cancer and the development of inhibitors. In our previous study, we studied PHGD...
Recycle, Repair, Recover: The Role of Autophagy in Modulating Skeletal Muscle Repair and Post-Exercise Recovery [0.03%]
回收、修复、恢复：自噬在调节骨骼肌修复和运动后恢复中的作用
Jordan Acheson,Sophie Joanisse,Craig Sale et al.
Jordan Acheson et al.
Skeletal muscle is a highly plastic tissue which can adapt relatively rapidly to a range of stimuli. In response to novel mechanical loading, e.g. unaccustomed resistance exercise, myofibers are disrupted and undergo a period of ultrastruct...
Does COVID-19 impact the QT interval prolongation? Answers from genetic causal inference [0.03%]
新冠会影响QT间期延长吗？来自遗传因果推断的答案
Yongfei Song,Zequn Zheng
Yongfei Song
During the COVID-19 pandemic, there has been heightened interest in the QT interval, a crucial indicator of ventricular electrical activity. Mendelian randomization (MR) is used here to investigate the genetic causation between QT interval ...
Insights into heme degradation and hydrogen peroxide induced dimerization of human neuroglobin [0.03%]
人神经球蛋白的血红素降解和双氧水诱导二聚化的研究心得
Alice Cassiani,Paul G Furtmuller,Marco Borsari et al.
Alice Cassiani et al.
In this work, we investigated the H2O2-induced oligomerization of wild-type human neuroglobin (hNgb) and of some selected variants (C46AC55A, Y44A, Y44F, Y44AC46AC55A, Y44AC46AC55A) to clarify how the process is affected by the Cys46/Cys55 ...
The physiological anti-hypertensive peptide catestatin and its common human variant Gly364Ser: differential cardiovascular effects in a rat model of hypertension [0.03%]
生理抗高血压肽catestatin及其常见的人体变异多肽Gly364Ser：在高血压大鼠模型中的不同心血管效应
Jitesh Singh Rathee,Dhanya R Iyer,Malapaka Kiranmayi et al.
Jitesh Singh Rathee et al.
Catestatin (CST), a 21-amino acids physiological peptide, has emerged as a key modulator of cardiovascular functions due to its anti-hypertensive and cardioprotective properties. However, the ramifications of the most common human variant o...
Transcriptional profiling reveals the role of Candida albicans Rap1 in oxidative stress response [0.03%]
转录组分析揭示白念珠菌Rap1在氧化应激反应中的作用
Wen-Han Wang,Hsuan-Yu Chen,Sheng-Yuan Chen et al.
Wen-Han Wang et al.
Candida albicans is a member of the human commensal microbiota but can also cause opportunistic infections, including life-threatening invasive candidiasis, particularly in immunocompromised patients. One of the important features of C. alb...
Retraction: Effects of microRNA-211 on proliferation and apoptosis of lens epithelial cells by targeting SIRT1 gene in diabetic cataract mice [0.03%]
撤回：miR-211通过靶向SIRT1基因抑制糖尿病性白内障小鼠晶状体上皮细胞增殖和诱导凋亡的作用机制研究
Retraction of Publication
Bioscience reports. 2024 Nov 27;44(11):BSR-2017-0695_RET. DOI:10.1042/BSR-2017-0695_RET 2024
Retraction: Progesterone receptor antagonist provides palliative effects for uterine leiomyoma through a Bcl-2/Beclin1-dependent mechanism [0.03%]
撤稿：孕激素受体拮抗剂通过Bcl-2/Beclin1依赖机制对子宫肌瘤产生姑息作用
Retraction of Publication
Bioscience reports. 2024 Nov 27;44(11):BSR-2019-0094_RET. DOI:10.1042/BSR-2019-0094_RET 2024