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Integrative Metabolome and Transcriptome Analyses Provide Insights into PHGDH in Colon Cancer Organoids

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As a rate-limiting enzyme in endogenous serine de novo synthesis pathway, PHGDH has been widely concerned about its role in a variety of tumors including colon cancer and the development of inhibitors. In our previous study, we studied PHGDH in colon cancer ce... ...