Integrative blood profiling uncovers inflammatory network signatures in high-altitude pulmonary edema [0.03%]
整合血液分析发现高原肺水肿的炎症网络标志物
Kanika Singh,Krishna Kumar G,Manzoor Ali et al.
Kanika Singh et al.
Despite the well-known role of hypoxia-driven inflammatory mediators in the pathogenesis of hypoxic pulmonary hypertension, their involvement in high-altitude (HA) illnesses, particularly high-altitude pulmonary edema (HAPE), remains unclea...
Bone morphogenetic protein (BMP)-9, a systemic homeostasis factor with diverse functions in the liver and beyond [0.03%]
骨形态发生蛋白(BMP)-9：一种全身稳态因子及其在肝脏等组织中的多种功能
Deeksha Rana-Seyfert,Anna Grab,Katja Breitkopf-Heinlein
Deeksha Rana-Seyfert
Bone Morphogenetic Protein-9 (BMP-9), a circulating cytokine belonging to the TGF-β superfamily, is increasingly recognized as a critical regulator of tissue homeostasis with diverse roles in both health and disease. This review recapitula...
Retraction: The protective role of MiR-206 in regulating cardiomyocytes apoptosis induced by ischemic injury by targeting PTP1B [0.03%]
撤稿：MiR-206通过靶向PTP1B调节缺血损伤诱导的心肌细胞凋亡的保护作用
Yejun Yan,Hongweing Dang,Xin Xhang et al.
Yejun Yan et al.
An overview of vital functions of human ecdysoneless (ECD), a highly conserved protein [0.03%]
人ecd蛋白的保肝和抗氧化功能及其与酒精性肝病的相关性研究
Kexin Liu,Xiankun Cao,Peixiang Ma et al.
Kexin Liu et al.
Human ecdysoneless (ECD), the human ortholog of Ecd protein of Drosophila melanogaster, is a highly conserved protein. This protein comprises a well-folded N-terminal domain and a disordered C-terminal domain; these domains interact with mu...
Retraction: STEAP1 facilitates metastasis and epithelial-mesenchymal transition of lung adenocarcinoma via the JAK2/STAT3 signaling pathway [0.03%]
撤回：STEAP1通过JAK2/STAT3信号通路促进肺腺癌转移和上皮间质转化
Shu-Fen Huo,Wen-Li Sheng,Min Yu et al.
Shu-Fen Huo et al.
Expression, purification, and in vitro characterization of the carboxylesterase CEST-9.2 from Caenorhabditis elegans [0.03%]
来源于秀丽隐杆线虫的羧酸酯酶CEST-9.2的表达、纯化及体外性质表征
Weijie Xu,Subhradeep Bhar,Rebecca Butcher
Weijie Xu
The nematode Caenorhabditis elegans biosynthesizes the ascarosides, a large, modular family of pheromones that are used in chemical communication. A number of carboxylesterase-like (CEST) enzymes are responsible for decorating the glycolipi...
Reduced structural rigidity of MDMX protein enhances binding to TP53 mRNA [0.03%]
MDMX蛋白刚度降低可增强与TP53 mRNA的结合力
Martina Kucerikova,Ondrej Bonczek,Vanesa Olivares-Illana et al.
Martina Kucerikova et al.
The two murine double minute (MDM) family members, MDM2 and MDMX are a well-established negative regulator of p53 activity. Under DNA damage conditions, MDM2 and MDMX are phosphorylated near their RING domains (serine 395 at MDM2 and serine...
The effect of the nonselective TNF inhibitor etanercept, and of the selective TNF inhibitor XPro1595 on lesioned supraspinatus muscle [0.03%]
非选择性肿瘤坏死因子抑制剂恩利和选择性TNF抑制剂XPro1595对肩袖损伤肌的影响
Christopher Aboo PhD,Kate Lykke Lambertsen PhD,Sohail Nasseri et al.
Christopher Aboo PhD et al.
The cytokine tumor necrosis factor (TNF), a major regulator of inflammatory responses, exists in both a membrane bound form and a soluble form. We used the nonselective TNF inhibitor etanercept, and the selective inhibitor XPro1595 and comp...
Transgenic mouse models of sodium and potassium channelopathies in epilepsy: insights into disease mechanisms and therapeutics [0.03%]
癫痫的钠和钾通道病转基因小鼠模型：对疾病机制和治疗的认识
Michael F Hammer
Michael F Hammer
Brain-expressed voltage-gated sodium (Nav) and potassium (Kv) channels are essential for maintaining the balance of neuronal excitability, each having opposing effects on membrane potential and neuronal firing. Genetic alterations in these ...
Expression of Concern: ANRIL promotes chemoresistance via disturbing expression of ABCC1 by regulating the expression of Let-7a in colorectal cancer [0.03%]
表达关注：ANRIL通过调节Let-7a的表达干扰ABCC1的表达从而促进结直肠癌化疗耐药性
Zhen Zhang,Lifeng Feng,Pengfei Liu et al.
Zhen Zhang et al.