Mild stress of caffeine increased mtDNA content in skeletal muscle cells: the interplay between Ca2+ transients and nitric oxide [0.03%]
咖啡因引起的轻度压力通过钙瞬变和一氧化氮的相互作用增加骨骼肌细胞中的线粒体DNA含量
Shuzhe Ding,Joanna Riddoch-Contreras,Andrey Y Abramov et al.
Shuzhe Ding et al.
Caffeine increases mitochondrial biogenesis in myotubes by evoking Ca(2+) transients. Nitric oxide (NO) also induces mitochondrial biogenesis in skeletal muscle cells via upregulation of AMP-activated protein kinase (AMPK) activity and PGC-...
Mechanical and kinetic properties of β-cardiac/slow skeletal muscle myosin [0.03%]
β-型心肌/慢抗肌球蛋白的力学和动力学性质研究
Bernhard Brenner,Nils Hahn,Eva Hanke et al.
Bernhard Brenner et al.
We aimed to establish reference parameters to identify functional effects of familial hypertrophic cardiomyopathy-related point mutations in the β-cardiac/slow skeletal muscle myosin heavy chain (β-cardiac/MyHC-1). We determined mechanica...
C Karatzaferi,G K Sakkas
C Karatzaferi
Changes in kinematic variables at various muscle lengths of human elbow flexors following eccentric exercise [0.03%]
离心收缩运动后人类屈肘肌在不同长度时的动力学变量的变化
Anastassios Philippou,Michael Koutsilieris,Maria Maridaki
Anastassios Philippou
Exercise-induced muscle damage causes a disproportionally larger drop in maximal force when measured at short versus optimal or long muscle lengths, resulting in a shift of the length (angle)-force relationship towards longer lengths. Howev...
The extent of cardiac myosin binding protein-C phosphorylation modulates actomyosin function in a graded manner [0.03%]
心肌肌球蛋白结合蛋白-C的磷酸化程度以分级方式调节肌动-肌浆球蛋白功能
Abbey E Weith,Michael J Previs,Gregory J Hoeprich et al.
Abbey E Weith et al.
Cardiac myosin binding protein-C (cMyBP-C), a sarcomeric protein with 11 domains, C0-C10, binds to the myosin rod via its C-terminus, while its N-terminus binds regions of the myosin head and actin. These N-terminal interactions can be atte...
Piyali Guhathakurta,Ewa Prochniewicz,Joseph M Muretta et al.
Piyali Guhathakurta et al.
Myosin's affinities for nucleotides and actin are reciprocal. Actin-binding substantially reduces the affinity of ATP for myosin, but the effect of actin on myosin's ADP affinity is quite variable among myosin isoforms, serving as the princ...
Pieter P de Tombe,Henk E D J ter Keurs
Pieter P de Tombe
A classical paper published by Michael Barany almost 50 years ago demonstrated a tight correlation between the mechanical parameter of maximal velocity of shortening and the biochemical parameter of myosin ATPase activity in a wide spectrum...
Residual force enhancement in skeletal muscles: one sarcomere after the other [0.03%]
骨骼肌残余力量增强：一节sarcomere再下一节sarcomere
Dilson E Rassier
Dilson E Rassier
The force-length relation is one of the most prominent features of striated muscles, and predicts that the force produced by a fully activated muscle is proportional to the overlap between myosin and actin filaments within sarcomeres. Howev...
New insights into myosin phosphorylation during cyclic nucleotide-mediated smooth muscle relaxation [0.03%]
环核苷酸介导的平滑肌松弛过程中肌球蛋白磷酸化的最新研究进展
Sandra Puetz,Mechthild M Schroeter,Heike Piechura et al.
Sandra Puetz et al.
Nitrovasodilators and agonists, via an increase in intracellular cyclic nucleotide levels, can induce smooth muscle relaxation without a concomitant decrease in phosphorylation of the regulatory light chains (RLC) of myosin. However, since ...
Mechanism of force enhancement during and after lengthening of active muscle: a temperature dependence study [0.03%]
主动肌肉在被拉长期间和之后增强的力量的机制：一项有关温度依赖性的研究
H Roots,G J Pinniger,G W Offer et al.
H Roots et al.
The aim of the present study was to examine the temperature dependence of active force in lengthening and shortening muscle. Experiments were done, in vitro, on bundles of intact fibres (fibre length L(0) ~2 mm; sarcomere length ~2.5 μm) i...