Temperature dependence of activation of thick and thin filaments in skeletal and cardiac muscles [0.03%]
骨骼肌和心肌粗细肌丝活化的温度依赖性
Shuya Ishii,Kotaro Oyama,Fuyu Kobirumaki-Shimozawa et al.
Shuya Ishii et al.
Contraction of striated muscle is initiated by an increase in the cytosolic Ca2+ concentration, which is regulated by tropomyosin and troponin on thin filaments in sarcomeres; viz., the binding of Ca2+ to troponin C shifts the "on-off" equi...
Hypertrophic cardiomyopathy-linked Tnnc1 variants are associated with distinct myopathic changes in slow skeletal muscle of mice [0.03%]
与肥厚型心肌病相关的Tnnc1变异体与小鼠慢缩骨骼肌中的不同肌病变化有关
Sonu Patel,Gabriel Leite da Silva Santos,Jaelynn Florence et al.
Sonu Patel et al.
Inherited hypertrophic cardiomyopathy (HCM) is considered a disease of the cardiac sarcomere and caused by pathogenic variants present in genes that encode sarcomeric proteins. The human TNNC1 gene is a designated HCM-susceptibility gene en...
A novel pulley-vest model enables progressive resistance exercise in rats without tail loading [0.03%]
一种新型滑轮背心模型可使大鼠在不施加尾部重量的情况下进行渐进阻力运动
Ronaldo André Castelo Dos Santos de Almeida,Jéssica da Silva Santos,Gabriel Souza de Jesus et al.
Ronaldo André Castelo Dos Santos de Almeida et al.
Resistance training in rodent models is widely used to investigate muscular and cardiovascular adaptations. Traditional models often attach loads to the tail. The present study aimed to develop and validate a resistance training model for r...
Sex-dependent responses to moderate/low-intensity swimming and loaded ladder-climbing resistance exercise in mdx mice [0.03%]
性别依赖的中低强度游泳和负重爬梯阻力运动对mdx小鼠的影响
Luana Lima Rocha da Silva,Tabata Gabriely Pereira Barbosa de Souza,Joice Luiza Silva Cassini et al.
Luana Lima Rocha da Silva et al.
Duchenne muscular dystrophy (DMD) is a severe genetic disorder characterized by progressive muscle degeneration, and the mdx mouse has been widely used to investigate disease mechanisms and therapeutic strategies, including the impact of di...
The pseudokinase domain PK1 of UNC-89/obscurin is required for mitochondrial morphology and function in C. elegans [0.03%]
线虫UNC-89/obscurn的假激酶结构域PK1对线粒体形态和功能是必需的
Yohei Matsunaga,Nasab Ghazal,Andreas Heim et al.
Yohei Matsunaga et al.
UNC-89 is a giant modular protein located at the sarcomeric M-line of C. elegans striated muscle and is required for sarcomere organization and function. UNC-89 contains two protein kinase domains, PK1 and PK2, separated by 850 residues, th...
Stretch-shortening cycles mitigate single muscle fibre power deficits following a two-week immobilization of the rat hindlimb [0.03%]
大鼠后肢两周转动受限后的单根肌纤维功率下降可通过拉伸-收缩周期得到缓解
Alexander M Zero,Geoffrey A Power
Alexander M Zero
Muscles undergo stretch-shortening cycles (SSCs) and following active stretching, work, and power during shortening are amplified compared with pure shortening contractions (i.e., SSC effect). We investigated the effects of immobilization o...
The role of melatonin in attenuation of vascular endothelin-1 reactivity via calcium channels and endothelial derived relaxing factors in STZ-induced diabetic aortic rats [0.03%]
糖尿病模型大鼠血管内皮素-1反应性的褪黑素调节机制研究
Chrakhan J Khdhir,Ridha H Hussein,Ismail M Maulood
Chrakhan J Khdhir
Glenn Carrington,Malika Zahedi,Michelle Peckham
Glenn Carrington
Smooth muscle cells are widespread in the human body, found in a range of tissues from the vasculature to the gut, airways, bladder and so on. They can be found as isolated cells or organised into syncytia (groups of cells). The organisatio...
Effects of culture media glucose concentration on LHCN-M2 skeletal muscle cell viability, differentiation and metabolic phenotype: a proof-of-concept study [0.03%]
培养基葡萄糖浓度对LHCN-M2骨骼肌细胞活力、分化和代谢表型的影响：概念验证研究
Ryan Brett,Leanne Hodson,Derek Renshaw et al.
Ryan Brett et al.
In vitro skeletal muscle culture models provide important insight into the cellular mechanisms which underpin skeletal muscle physiology and metabolism in health and disease. The establishment of a model that can be cultured in physiologica...
Amiodarone disrupts thyroid hormone homeostasis and impairs myogenic progression and locomotor function in zebrafish embryos [0.03%]
胺碘酮扰乱甲状腺激素稳态并损害斑马鱼胚胎的肌源性发育和运动功能
Juhi Vaishnav,Abhinav Upadhyay,Arya Bhatt et al.
Juhi Vaishnav et al.