HMGB1 expression and muscle regeneration in idiopathic inflammatory myopathies and degenerative joint diseases [0.03%]
自身免疫性肌炎和退行性关节疾病患者肌肉组织中HMGB1的表达及意义研究
Karolina Cseri,János Vincze,Julianna Cseri et al.
Karolina Cseri et al.
The High-Mobility Group Box 1 protein (HMGB1) is a known nuclear protein which may be released from the nucleus into the cytoplasm and the extracellular space. It is believed that the mobilized HMGB1 plays role in the autoimmune processes a...
Distinct muscle apoptotic pathways are activated in muscles with different fiber types in a rat model of critical illness myopathy [0.03%]
重症肌病大鼠模型中不同纤维类型的肌肉激活不同的肌肉凋亡途径
Benjamin T Barnes,Amy L Confides,Mark M Rich et al.
Benjamin T Barnes et al.
Critical illness myopathy (CIM) is associated with severe muscle atrophy and fatigue in affected patients. Apoptotic signaling is involved in atrophy and is elevated in muscles from patients with CIM. In this study we investigated underlyin...
Contribution of impaired myofibril and ryanodine receptor function to prolonged low-frequency force depression after in situ stimulation in rat skeletal muscle [0.03%]
大鼠骨骼肌在体刺激后低频力下降持续时间延长对横桥和ryanodine受体功能损伤的贡献
Daiki Watanabe,Keita Kanzaki,Mai Kuratani et al.
Daiki Watanabe et al.
The aim of this study was to examine whether prolonged low-frequency force depression (PLFFD) that occurs in situ is the result of decreased myofibrillar Ca(2+) sensitivity and/or reduced sarcoplasmic reticulum (SR) Ca(2+) release. Intact r...
Slow motor units in female rat soleus are slower and weaker than their male counterparts [0.03%]
慢缩运动单元在雌性大鼠腓肠肌中比雄性更弱、收缩速度更慢
Hanna Drzymała-Celichowska,Piotr Krutki
Hanna Drzymała-Celichowska
The aim of the study was to investigate sex-related differences in contractile properties, parameters of action potentials, and mechanisms of force regulation of motor units in the rat soleus muscle, which is a frequent experimental model i...
Dyad content is reduced in cardiac myocytes of mice with impaired calmodulin regulation of RyR2 [0.03%]
卡钙调神经磷酸酶调节功能受损小鼠心肌细胞中的二聚体含量减少
Manuela Lavorato,Tai-Qin Huang,Venkat Ramesh Iyer et al.
Manuela Lavorato et al.
In cardiac muscle, calmodulin (CaM) regulates the activity of several membrane proteins involved in Ca(2+) homeostasis (CaV1.2; RyR2, SERCA2, PMCA). Three engineered amino acid substitutions in the CaM binding site of the cardiac ryanodine ...
What has the mdx mouse model of Duchenne muscular dystrophy contributed to our understanding of this disease? [0.03%]
Duchenne肌营养不良症的mdx小鼠模型对疾病研究有哪些贡献？
Jennifer Manning,Dervla O&#x;Malley
Jennifer Manning
Duchenne muscular dystrophy (DMD) is a fatal X-chromosome linked recessive disorder caused by the truncation or deletion of the dystrophin gene. The most widely used animal model of this disease is the dystrophin-deficient mdx mouse which w...
Dissecting human skeletal muscle troponin proteoforms by top-down mass spectrometry [0.03%]
利用顶部向下质谱法解析人类骨骼肌肌钙蛋白蛋白质形式
Yi-Chen Chen,Marius P Sumandea,Lars Larsson et al.
Yi-Chen Chen et al.
Skeletal muscles are the most abundant tissues in the human body. They are composed of a heterogeneous collection of muscle fibers that perform various functions. Skeletal muscle troponin (sTn) regulates skeletal muscle contraction and rela...
The neonatal sarcoplasmic reticulum Ca2+-ATPase gives a clue to development and pathology in human muscles [0.03%]
新生儿肌浆网Ca2+-ATP酶为人类肌肉的发育和病理研究提供线索
Magdolna Kósa,Kitti Brinyiczki,Philip van Damme et al.
Magdolna Kósa et al.
The sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) has two muscle specific splice isoforms; SERCA1a in fast-type adult and SERCA1b in neonatal and regenerating skeletal muscles. At the protein level the only difference between...
Inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA1) by rutin derivatives [0.03%]
芦丁衍生物对肌浆网Ca2+-ATP酶(SERCA1)的抑制作用
Jana Viskupicova,Magdalena Majekova,Lubica Horakova
Jana Viskupicova
The effect of lipophilic rutin derivatives (acylated with fatty acid chain length of 16-22) on sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA1 isoform) compared to the parent molecule rutin was evaluated. Rutin derivatives caused concentr...
Masataka Kawai,Graham Lamb,Stefan Galler
Masataka Kawai