Autophagy in Rheumatoid Arthritis: Molecular Mechanisms, Diagnostic Biomarkers, and Emerging Therapeutic Strategies [0.03%]
自身噬作用在类风湿关节炎中的分子机制、诊断生物标志物和新兴治疗策略
Amir Nasrollahizadeh,Soheil Rahmati,Mohammad Sadra Gholami Chahkand et al.
Amir Nasrollahizadeh et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disorder marked by persistent synovial inflammation, joint destruction, and systemic complications. Recent research has revealed the complex involvement of autophagy, a cellular degradation ...
Free Fatty Acids and LPS Synergistically Promote Macrophage M1 Polarization and Insulin Resistance Via FTO-Mediated CSF1 Degradation [0.03%]
游离脂肪酸和LPS通过FTO介导的CSF1降解协同促进M1型巨噬细胞极化及胰岛素抵抗
Xiaohui Xiao,Junhao Zhao,Guiwen Ye et al.
Xiaohui Xiao et al.
Free fatty acids (FFA) and lipopolysaccharide (LPS) synergistically exacerbate metabolic inflammation, but the underlying mechanisms remain unclear. This study investigates how FFA and LPS cooperatively promote macrophage M1 polarization an...
Indole-3-aldehyde Preserves Gingival Epithelial Barrier Structure and Function Via AhR/Nrf2 Signaling Pathway [0.03%]
吲哚-3-甲醛通过AhR/Nrf2信号通路保存牙龈上皮屏障的结构和功能
Lingzhi Wu,Shiwen Wu,Yuquan Deng et al.
Lingzhi Wu et al.
Indole-3-aldehyde (IAld), an indole derivative of tryptophan metabolized by microorganisms, has been observed to improve epithelial barriers in multiple chronic inflammatory diseases through the aryl hydrocarbon receptor (AhR). This study a...
Machine Learning Identifies Key Cells and Therapeutic Targets in Intervertebral Disc Degeneration: SASP-Driven Matrix Catabolism, Inflammation Amplification, and Metabolic Collapse [0.03%]
机器学习鉴定椎间盘退变中的关键细胞和治疗靶点：SASP驱动的基质降解、炎症放大和代谢崩溃
Yi Kang,Manglai Li,Baoyang Hu et al.
Yi Kang et al.
Intervertebral disc degeneration (IVDD) is a major contributor to low back pain, yet its cellular and molecular mechanisms remain incompletely understood. In this study, we integrated single-cell and bulk transcriptomic data to uncover the ...
Astrocytic SIRT3 Alleviates Neuroinflammatory Responses After Cerebral Ischemia/reperfusion by Inhibiting the cGAS-STING Pathway [0.03%]
星形胶质细胞SIRT3通过抑制cGAS-STING通路缓解脑缺血再灌注后神经炎症反应
Wen Lei,Yang Dong,Hao Zhuang et al.
Wen Lei et al.
Ischemic stroke triggers detrimental neuroinflammatory responses where astrocytes play a pivotal role. This study investigates whether Sirtuin 3 (SIRT3), a key cellular regulator, mitigates astrocyte-mediated neuroinflammation by modulating...
Bone Morphogenetic Protein 6 Attenuates Psoriasis Pathogenesis by Suppressing Th17 Cell Differentiation [0.03%]
骨形态发生蛋白6通过抑制Th17细胞分化来减弱银屑病的发病机制
Jingfei Fu,Yingyi Chen,Rui Zhao et al.
Jingfei Fu et al.
Bone morphogenetic protein (BMP) signaling has multiple functions in immune cells, especially in the differentiation of T cells. Previously, we found that BMP6 can dramatically promote the IFN-γ production in Th1. However, the interactions...
cGAMP Enhances Microglial/Macrophage Phagocytosis in Ischemic Stroke Via Activation of the TREM2-DAP10-PI3K Pathway [0.03%]
cGAMP通过激活TREM2-DAP10-PI3K通路增强缺血性卒中后的微胶质细胞/巨噬细胞吞噬作用
Xinyu Li,Huamin Ding,Shuyu Qian et al.
Xinyu Li et al.
Ischemic stroke (IS), a multifaceted neurodegenerative disorder characterized by neuroinflammation and neuronal damage, is critically linked to the cGAS-STING pathway, a key mediator of neuroinflammatory responses during cerebral ischemia. ...
GPR40 Attenuates Age-Related Macular Degeneration by Suppressing Retinal Microglial NLRP3 Inflammasome Activation Via ERK Signaling [0.03%]
GPR40通过ERK信号传导抑制视网膜小胶质细胞NLRP3炎性体活化从而缓解年龄相关性黄斑变性疾病
Xin Tan,Jianshu Kang,Hongkun Zhao et al.
Xin Tan et al.
Retinal neuroinflammation is a key pathological feature of age-related macular degeneration (AMD), primarily driven by aberrant microglial cell activation. The expression and role of G-protein-coupled receptor 40 (GPR40), in AMD remain uncl...
Inhibition of SPI1 by ADAP Regulates S100A8/A9 Signaling in Macrophages to Control the Development of Colitis [0.03%]
ADAP通过抑制SPI1调控巨噬细胞中S100A8/A9信号通路以控制结肠炎的发展
Yanqi Wang,Xiao Li,Xinyue Lv et al.
Yanqi Wang et al.
Although the immune adaptor protein ADAP (adhesion and degranulation adaptor protein) plays a critical role in regulating macrophage inflammatory responses, its impact on intestinal inflammation remains elusive. This study reveals that ADAP...
Metrnl/Meteorin-like/IL-41 Alleviates Rheumatoid Arthritis Via PPARγ-Mediated Suppression of Inflammation, Angiogenesis, and Bone Destruction [0.03%]
母核蛋白/气象体素样/白细胞介素41通过PPARγ介导的抑制作用缓解类风湿性关节炎：抗炎、抗血管生成和抗骨破坏作用
Tao Sun,Liping Xia,Yuxuan Li et al.
Tao Sun et al.
Rheumatoid arthritis (RA), an autoimmune disease, is characterized by synovial hyperplasia, vascular occlusion, and bone erosion. Metrnl, a novel secreted protein linked to inflammatory immune regulation, has been implicated in RA pathogene...