Plasminogen Activation System and Fibroblasts: Impact on Tissue Remodeling, Disease, and Organ Homeostasis [0.03%]
纤溶活化系统与成纤维细胞：对组织重塑、疾病和器官稳态的影响
Fathimath Muneesa Moideen,Yashodhar Prabhakar Bhandary
Fathimath Muneesa Moideen
The interplay between fibroblasts and the plasminogen activation system is increasingly recognized as a central driver of fibrosis, thrombosis, and cancer progression. Fibroblasts, as key producers of extracellular matrix (ECM), regulate ti...
Systemic Inflammation Triggers Motor Axon Degeneration Via Macrophage IL-1β-Mediated P53/SIRT1/Autophagy Pathway [0.03%]
炎性细胞因子白介素-1β通过P53/SIRT1/自噬信号通路诱发运动轴索变性
Bowen Sun,Jie Li,Xuexin Li et al.
Bowen Sun et al.
Background: Axonal degeneration of motor neurons is a hallmark pathological feature of neurodegenerative diseases, culminating in motor dysfunction in advanced stages. Systemic inflammation exacerbates motor dysfunction, ...
The CEBPB-AP-1 (JunB/Fos) Axis Drives Neuroinflammation and Microglial Dysfunction Via TNF Signaling in Ischemic Stroke [0.03%]
CEBPB-AP-1（JunB/Fos）轴通过TNF信号通路驱动缺血性脑卒中的神经炎症和小胶质细胞功能障碍
Kun Liang,Shuangshuang Lu,Weihao Shi et al.
Kun Liang et al.
Ischemic stroke triggers a strong neuroinflammatory response, with microglia playing dual roles in both exacerbating tissue damage and promoting repair. The molecular mechanisms regulating microglial activation and polarization remain inade...
GBP5 Aggravates Acute Lung Injury Via NLRP3 Inflammasome Activation While Inducing a HIF-1α-CD73-adenosine Feedback Loop [0.03%]
铜通过NLRP3炎症小体激活加重急性肺损伤，同时诱导HIF-1α-CD73-腺苷反馈回路
Jia Zhang,Linshu Xie,Xinyu Yang et al.
Jia Zhang et al.
Guanylate-binding protein 5 (GBP5) is an interferon-inducible GTPase that promotes NLRP3 inflammasome activation. However, its role in acute lung injury (ALI) and its relationship with compensatory anti-inflammatory pathways remain poorly d...
ID2 Regulates Macrophage Polarization and Mediates Methotrexate Responsiveness in Rheumatoid Arthritis [0.03%]
IDO2调节巨噬细胞极化并介导抗风湿病药物甲氨蝶呤的疗效
Lu Ye,Xiaomei Wang,Huaxiang Wu et al.
Lu Ye et al.
Methotrexate (MTX) is the first-line treatment for rheumatoid arthritis (RA), but patient responses are highly variable. Macrophages are central drivers of RA inflammation, yet how monocyte/macrophage heterogeneity and transcriptional progr...
Hepatocyte-Derived S100A4/A6/A10/A11 Proteins Promote Liver Fibrosis by Direct and Indirect Activation of HSCs [0.03%]
肝细胞来源的S100A4/A6/A10/A11蛋白通过直接和间接激活HSCs促进肝纤维化
He Tong,Yingxue Zhang,Haiting Pan et al.
He Tong et al.
Liver fibrosis is a chronic disease caused by various etiologies, including dysregulated interactions among hepatocytes, KCs, and HSCs. Studies have shown that the S100 protein family plays an important role in liver fibrosis, especially th...
CXCL10-LACTC1/C2 Expressing Mesenchymal Stem Cell Conditioned Medium Attenuates TNF-α-Induced Gene Expressions and Cell Viability in HUVECs [0.03%]
CXCL10-LACTC1/C2 表达间充质干细胞诱导的培养基减轻TNF-α 诱导的HUVEC基因表达和细胞活力损伤
Kaya Molo,Ruken Ege,Kübra Ati̇k et al.
Kaya Molo et al.
Infectious diseases exacerbate atherosclerosis-associated morbidity and mortality by inducing sustained inflammatory responses characterized by elevated IL-6, TNF-α, IFN-γ, and CXCL10. Persistent CXCL10-driven recruitment of CXCR3⁺ immun...
Inhibition of MyD88 in Tubular Epithelial Cells Alleviates the Cellular Senescence in Sepsis-Associated Acute Kidney Injury [0.03%]
抑制MyD88可缓解脓毒症急性肾损伤的细胞衰老
Yan Zhang,Yali Wang,Yingxin Zhao et al.
Yan Zhang et al.
Cellular senescence has emerged as an important contributor to acute kidney injury (AKI); however, its role in sepsis-associated acute kidney injury (SA-AKI) remains insufficiently characterized. This study aimed to investigate the involvem...
Pharmacological Characterization of GLPG3667, a Tyrosine Kinase 2-Selective Inhibitor, for the Treatment of Inflammatory and Autoimmune Diseases [0.03%]
GLPG3667的药理学表征，一种选择性酪氨酸激酶2抑制剂，用于治疗炎症和自身免疫性疾病
Céline Cottereaux,May-Linda Lepage,Isabelle Parent et al.
Céline Cottereaux et al.
Janus kinase inhibitors have demonstrated efficacy in treating inflammatory and autoimmune diseases; however, several concerns restrict their use in medical practice. One member of this kinase family, tyrosine kinase 2 (TYK2), recently attr...
USP43 Inhibits Intestinal Inflammation via TRAF4-mediated NF-κB Signaling [0.03%]
USP43通过TRAF4介导的NF-κB信号抑制肠道炎症
Li Zhou,Dongliang Li,Yan Lv et al.
Li Zhou et al.
Ulcerative colitis (UC) is a chronic inflammatory intestinal disorder; however, its exact pathophysiological mechanisms remain elusive. Through integrated RNA-seq and proteome analyses, we revealed that ubiquitin-specific protease 43 (USP43...