Shohini Banerjee,Corey Herr,Wolfgang Losert et al.
Shohini Banerjee et al.
Estradiol (E2), a sex steroid hormone molecule, plays a key role in regulating the actin and shape dynamics of cells in a multitude of normal and pathophysiological conditions. While cytoskeletal rearrangements, membrane dynamics, and cellu...
Impact of the hen egg size on its fracture point measuring the eggshell deformation [0.03%]
母鸡 eggs大小对其蛋壳破裂点的影响及测量变形
Brenda Mireya Guzman Valdivia,Manuel Humberto De La Torre Ibarra
Brenda Mireya Guzman Valdivia
A digital holographic interferometer is used to measure surface deformation and fracture points in hen eggs under mechanical compression. All samples were subjected to a constant compression load until they fractured. Three different tests ...
Computational and umbrella sampling analysis of HER2 D769H and D769Y variants: mutation-specific structural alterations and drug interactions in breast cancer [0.03%]
HER2 D769H 和 D769Y 变体的计算和伞采样分析：乳腺癌中突变特异性结构改变及药物作用机制
Tamizhini Loganathan,George Priya C Doss
Tamizhini Loganathan
HER2 plays a crucial role in breast cancer (BC) progression, with the D769H and D769Y mutations significantly influencing its structural integrity, drug-binding dynamics, and therapeutic response. This study employs molecular docking and mo...
Elucidating motion patterns in sperm cell motion with dynamic mode decomposition [0.03%]
基于动态模式分解的精子运动模式研究
Petr Šimánek,Jakub Hořenín,Islam S M Khalil et al.
Petr Šimánek et al.
The study employs dynamic mode decomposition (DMD) to elucidate the underlying mechanisms contributing to the enhanced motility observed in sperm bundles, primarily focusing on the role of flagellar synchronization. The decomposition reveal...
In silico ADMET profiling and DNA interaction study of xanthoxylin: assessment of pBR322 DNA protection against oxidative damage [0.03%]
基于计算机的 ADMET 血浆蛋白结合力研究及羟胡桃青素与DNA相互作用的研究及对pBR322 DNA氧化损伤的保护评估
Mohd Abuzar Afaq,Mohammad Tabish
Mohd Abuzar Afaq
DNA is one of the primary intracellular targets for various anticancer drugs. Insight into the ligand-DNA interactions is critical for developing novel, promising bioactive molecules for therapeutic use. This is greatly aided by interpretin...
Quantum mechanical justification for induced fit model conformational changes in allosteric enzymes based on the quantum perturbation theory and Davydov's soliton theory [0.03%]
基于量子摄动理论和Davydov局域化激子理论的非底物诱导拟合模型构象变化的量子力学解释
Farzam Faeznia
Farzam Faeznia
We develop a refined quantum framework for the induced-fit model of allosteric enzymes incorporating vibrational exciton (Davydov's soliton) dynamics and open-system perturbation theory. Using realistic biochemical parameters, we numericall...
Stiff for the stride and soft for the glide: dual role of cytoskeleton in stiffness dynamics of breast cancer cell lines-a meta-analysis [0.03%]
乳腺癌细胞系刚度动力学的元分析：细胞骨架的双重作用
Anusri Ambali,Koolipoyil Abdulkareem Rishad,Thuluvath Linshina et al.
Anusri Ambali et al.
Estimation of cell stiffness has assumed significance as their difference in cancer and normal cells is being exploited for diagnostic and therapeutic purposes. However, the cell stiffness values reported (in terms of elastic modulus (E)) a...
Influence of osmosis, screening charges, and electrical neutrality of nanopores on object translocation [0.03%]
渗透压、纳米孔道表面电荷和电中性对分子传输的影响
Mladen I Glavinović
Mladen I Glavinović
It has been known for a long time that osmosis transfers water from low to high salt concentrations, but few simulation studies have been conducted in confined spaces. This study evaluated the osmotic axial pressure at charged disk surfaces...
2D modeling of micropost-induced flow fields and biofilm adhesion mechanisms: a CA-FEM approach for flow-biofilm interactions in microfluidic channels [0.03%]
基于CA-FEM方法的微流控通道中流动-生物膜相互作用的二维建模：微柱诱导流场及生物膜吸附机制
Zhiqian Ma,Zheng Zhang,Yangyang Tang et al.
Zhiqian Ma et al.
Biofilms are widely present in any environment with water and a substrate, posing microbial contamination risks to flow pipelines. This study established a bacterial biofilm flow growth model based on the experimental phenomena of Bacillus ...
Electric fields promote exosome secretion and facilitate wound healing in HaCaT cells [0.03%]
电场促进外泌体释放并有助于HaCaT细胞的伤口愈合
Jiacheng Jiang,Xiaoli Guo,Xue Chen et al.
Jiacheng Jiang et al.
Exosomes released by epithelial keratinocytes and dermal fibroblasts significantly accelerate wound healing. Moreover, endogenous electric fields (EFs) were demonstrated to promote wound healing by directing the migration of epidermal cells...