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Mapping increased flexibility and conformational divergence via N-terminal helix-to-coil transition in USP12 mutant Y49N: a comprehensive in-detail normal mode simulation study

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The family of deubiquitinating enzymes is primarily involved in the removal of ubiquitin chains from specific target proteins. Among these proteins, ubiquitin-specific protease 12 (USP12 protein) has been identified as a key molecule in regulating cellular hom... ...