Iron (III) emissions from seawater desalination plants: a new, hitherto overlooked contribution to the iron cycle in coastal seas? [0.03%]
海水淡化厂的铁(III)排放：对沿海海洋铁循环的新贡献？
Frithjof C Küpper,Mohammed Khalid Massoud,Eleni Avramidi et al.
Frithjof C Küpper et al.
Due to the poor solubility of iron (III) and strong regional differences in terrestrial, riverine or airborne input, iron is a limiting micronutrient in much of the world ocean. Because of increasing living standards and climate change, rai...
Concomitant induction of apoptosis and suppression of epithelial-mesenchymal transition (EMT) by a Cu(II)-flavonoid complex in colorectal cancer [0.03%]
铜(ii)-黄酮复合物诱导结直肠癌细胞凋亡并抑制上皮间质转化(EMT)
Sibel Cinar-Asa,Hasene Mutlu-Genckal,Ferda Ari
Sibel Cinar-Asa
Notwithstanding progress in chemotherapy, cancer recurrence resulting from metastasis continues to be a significant challenge. Consequently, targeting the epithelial-mesenchymal transition (EMT) has emerged as a viable approach to impede me...
Zinc sulfate modulates the C3H10T1/2 mesenchymal stem cell line secretome and NFκB signaling during inflammation to influence selected immune cell responses [0.03%]
硫酸锌通过调节C3H10T1 / 2间充质干细胞系的分泌组和炎症期间的NFκB信号传导来影响选定的免疫细胞反应
Edson Naoto Makiyama,Iolanda Silva Rafael Pizzolato-Cezar,Sumara de Freitas et al.
Edson Naoto Makiyama et al.
Zinc (Zn) is essential for immune cell function, while mesenchymal stem cells (MSCs) exert immunomodulatory effects primarily through the secretion of soluble factors. Considering the ability of MSCs and Zn to modulate the immune and inflam...
Molecular and cellular mechanisms of lead-induced neurotoxicity: comparative insights from rodent and zebrafish models [0.03%]
分子和细胞层面的铅致神经毒性作用机制：来自啮齿类动物和斑马鱼模型的研究比较见解
Sayed Mohammed Firdous,Durga Maity,Souvik Marick
Sayed Mohammed Firdous
Lead is a persistent environmental heavy metal and a potent neurotoxin that continues to threaten global public health despite regulatory restrictions. Chronic and developmental exposure, particularly during early life, leads to persistent ...
Exogenous hesperidin orchestrates antioxidant defense, osmolyte metabolism, and nutrient homeostasis to mitigate heavy metal toxicity in canola [0.03%]
外源柚皮素通过调控抗氧化防御、渗透调节物质代谢及营养元素稳态缓解重金属毒性：以油菜为例
Sherjeel Hashmat,Humaira Yasmeen,Bakhrom Jobborov et al.
Sherjeel Hashmat et al.
Heavy metal contamination of agricultural soils severely impairs plant physiological function by disrupting nutrient uptake, photosynthesis, and redox homeostasis. Previous studies have established that heavy metals such as cadmium (Cd), ch...
Effects of copper overload on mitochondrial parameters in GBM-1, U-87 MG, and C6 glioma cell lines [0.03%]
铜过载对GBM-1、U-87 MG和C6胶质瘤细胞系线粒体参数的影响
Giovanna Tassinari,Lorena Aparecida de Souza,Nikole Aguiar de Souza et al.
Giovanna Tassinari et al.
Over the years, there has been growing interest in developing new therapies for glioblastoma, and copper compounds have emerged as promising therapeutic targets due to their antitumoral properties. In this context, this study aimed to inves...
The toxic footprint of lead exposure: oxido-inflammatory biomarkers in urban populations of Niger Delta, Nigeria [0.03%]
尼日尔河三角洲地区尼日利亚城市人群铅暴露的毒害足迹：氧化炎性生物标志物
Eudora Obioma Nwanaforo,Cecilia N Obasi,Prosper Manu Abdulai et al.
Eudora Obioma Nwanaforo et al.
Lead (Pb) exposure is still a major public health concern in southern Nigeria's urban and industrial areas. This study examined the relationship between blood lead levels (BLLs) and biomarkers related to oxido-inflammatory, antioxidant, ren...
Nano-enabled strategies for iron deficiency and iron deficiency anemia: iron-based nanoparticles for supplementation, bioavailability, and food fortification-a narrative review [0.03%]
基于纳米技术的防治缺铁性贫血策略：用于补铁、生物利用度和食品强化的铁基纳米颗粒-叙述性综述
Eslem Çınar,Su Beyde,Kaan Zıkşahna et al.
Eslem Çınar et al.
Iron deficiency and iron deficiency anemia (IDA) remain highly prevalent worldwide and are associated with substantial morbidity, especially among infants, children, women of reproductive age, and individuals with chronic diseases. Conventi...
Multimodal microscopic and spectroscopic characterisation of heterogeneous iron oxyhydroxides in the human globus pallidus [0.03%]
人脑壳顶核中铁氧化氢合物的多模态微观及光谱表征
Martin Kopáni,Daniel Kosnáč,Pavol Gemeiner et al.
Martin Kopáni et al.
Iron is essential for neuronal metabolism, neurotransmitter synthesis, and enzymatic function; however, dysregulated accumulation contributes to oxidative stress and neurodegeneration. The basal ganglia, particularly the globus pallidus, re...
Functional characterization of a novel ZIP8 variant causing impaired manganese homeostasis and congenital disorders of glycosylation [0.03%]
一种新型ZIP8变异体的功能表征，该变异体导致锰稳态受损和先天性糖基化障碍疾病
Hitomi Fujishiro,Naoya Morisada,Nao Mitani et al.
Hitomi Fujishiro et al.
ZIP8, encoded by SLC39A8, mediates cellular uptake of divalent metal ions, including manganese (Mn). Mutations in SLC39A8 cause a congenital disorder of glycosylation (CDG) associated with Mn deficiency (SLC39A8-CDG). Here, we report a nove...