Hypoxia and ascorbic acid: two interconnected microenvironmental factors driving collagen biosynthesis [0.03%]
缺氧和抗坏血酸：两种相互关联的微环境因素，可驱动胶原生物合成
Méline Ricol,Oskar Lipinski,Catherine Moali et al.
Méline Ricol et al.
Inadequate collagen deposition is at the core of various pathologies, including non-healing wounds, fibrotic diseases, and tumour progression. It is therefore paramount to fully understand how central effectors affect collagen synthesis and...
Arylsulfatase I is a novel lysosomal chondroitin endosulfatase regulating endochondral ossification [0.03%]
新型的溶酶体基质凝集素硫酸盐酯酶Arylsulfatase I参与软骨内成骨作用
Rafaela Grecco-Machado,Satomi Nadanaka,Yuko Naito-Matsui et al.
Rafaela Grecco-Machado et al.
During endochondral ossification, chondrocytes undergo maturation and biochemically modify the collagenous extracellular matrix of cartilage. Similar modifications to cartilage proteoglycans (PGs), which are predominantly chondroitin sulfat...
Shuqian Dou,Xin Wang,Yongjing He et al.
Shuqian Dou et al.
Background: While fetal skin achieves scarless healing, the molecular mechanisms underlying this regenerative capacity remain incompletely characterized. This study integrates single-cell RNA sequencing with spatial trans...
Glutamine-dependent changes in fibroblast-derived extracellular matrix dictate cancer cell behavior [0.03%]
谷氨酰胺决定成纤维细胞源性胞外基质的变化影响癌细胞行为
Julien Guillard,Jessica Stradley,Kristof Turan et al.
Julien Guillard et al.
The extracellular matrix (ECM) provides key biochemical and biomechanical cues that govern fundamental cellular processes, including growth and migration. ECM dysregulation and altered cell-matrix interactions are drivers of cancer progress...
Laminin-α2 is required for the maintenance of the myotendinous junction in vivo [0.03%]
层粘连蛋白-α2对体内肌腱连接的维持是必需的
Julia Schedel,Shuo Lin,Thomas Bock et al.
Julia Schedel et al.
The myotendinous junction (MTJ) is a critical interface between muscle fibers and tendons, essential for force transmission between muscle and bone. Laminin-α2, a key extracellular matrix (ECM) component, is strongly enriched at this inter...
Observations of dystrophic epidermolysis bullosa patients with collagen VII NC2 truncation provide new insights into anchoring fibril assembly [0.03%]
COL7S3突变纯合子营养不良型大疱性表皮松解症患者的临床和组织病理学特征为锚丝装配提供新视角
Neha S Momin,I Sinem Bagci,John A Dolorito et al.
Neha S Momin et al.
Type VII collagen (C7) assembles into anchoring fibrils (AF) which are basement membrane zone (BMZ) structures that reinforce dermal-epidermal cohesion. Mutations in COL7A1, which encodes C7, cause dystrophic epidermolysis bullosa (DEB), a ...
Corrigendum for "Oxygen and TGF-β1 jointly regulate fibronectin and trophoblast behavior highlighting a potential role for matrix signaling in severe preeclampsia" [Matrix Biology 144 (2026) 13-25] [0.03%]
“氧气和TGF-β1共同调节纤维连接蛋白和滋养细胞行为，突显严重子痫前期中基质信号传导的潜在作用”的勘误表（矩阵生物学第144期（2026）13-25页）
Felipe Gallardo,Delia I Chiarello,Ivo Carrasco-Wong et al.
Felipe Gallardo et al.
Abnormal extracellular matrix deposition by fascial fibroblasts underlies the connective tissue pathology in the disease Radial Dysplasia [0.03%]
筋膜成纤维细胞异常沉积细胞外基质是辐状发育不良结缔组织病理的基础
Eleanor M Feneck,Jack Morgan,Ferheen Baig et al.
Eleanor M Feneck et al.
Fibroblast cells are broadly distributed throughout the body and play instructive roles in tissue development and homeostasis. Defects in fibroblast function have been associated with developmental disorders, cancer and inflammatory disease...
A switch in collagen expression regulates cessation of distal tip cell migration in C. elegans [0.03%]
胶原蛋白表达的转换调节C. elegans远端上皮细胞迁移的停止
Victor Stolzenbach,Sophie S Griffin,Luke Goncalves et al.
Victor Stolzenbach et al.
Development of the C. elegans gonad requires precise regulation of cell migration. The distal tip cell (DTC) guides the elongation of the gonad into its final U-shaped structure before halting in adulthood. How cessation of elongation is re...
An integrin α3β1-CSTF3 signaling axis regulates alternative polyadenylation of Mmp9 mRNA [0.03%]
整合素α3β1-CSTF3信号轴调控Mmp9 mRNA可变多聚腺苷酸化事件
Giesse Albeche Duarte,Ramon Bossardi Ramos,Lei Wu et al.
Giesse Albeche Duarte et al.
The laminin-binding integrin α3β1 is highly expressed in epidermal keratinocytes, where it coordinates diverse cellular functions and gene expression during skin remodeling. Here, we show that α3β1-MEK/ERK signaling operates in vivo to ...