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Arylsulfatase I is a novel lysosomal chondroitin endosulfatase regulating endochondral ossification

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During endochondral ossification, chondrocytes undergo maturation and biochemically modify the collagenous extracellular matrix of cartilage. Similar modifications to cartilage proteoglycans (PGs), which are predominantly chondroitin sulfate PGs, have not been... ...