Tenascin‑C promotes epidural fibrosis via regulating caveolin-1-mediated TGFβRI internalization [0.03%]
Zeyuan Song,Yue Huang,Youpeng Zhao et al.
Zeyuan Song et al.
Excessive deposition of extracellular matrix (ECM) following laminectomy contributes to epidural scar formation, which is associated with postoperative lumbodorsal pain. This study aimed to investigate the role and mechanisms of the ECM gly...
Yan Wang,Johannes F van Agthoven,Eugene P Rhee et al.
Yan Wang et al.
Testican-2 (SPOCK2) is a secreted, extracellular matrix-associated proteoglycan that modulates cell-matrix interactions, extracellular proteolysis, and tissue-specific signaling across multiple organs. Beyond its initial characterization in...
Loss of Type III Collagen has Limited Effect on Tendon Healing in Young Adult Mice [0.03%]
III型胶原丢失不影响年轻小鼠肌腱愈合
Margaret K Tamburro,Jaclyn A Carlson,William K Yen et al.
Margaret K Tamburro et al.
Tendon injuries account for considerable and escalating clinical burden. After injury, tendons heal poorly with persistent fibrovascular scar. Unlike healthy tendon which is type I collagen (COL1)-rich and highly-aligned, fibrovascular scar...
C-terminally clustered UGDH hypomorphic variants reveal subtle mechanisms of cellular and developmental disruption [0.03%]
簇状的末端UGDH低渗变异体揭示了细胞和发育干扰的细微机制
Hali Harwood,Brenna M Zimmer,Asher R Utz et al.
Hali Harwood et al.
Jamuar syndrome (Developmental and Epileptic Encephalopathy 84, OMIM# 618792) is a rare autosomal recessive congenital disorder of glycosylation (CDG), caused by variations in the gene encoding UDP-glucose dehydrogenase (UGDH). Although a n...
Cytokine Conversations: Fibroblasts Shape Macrophage Identity to Enhance Collagen Clearance [0.03%]
细胞对话：成纤维细胞通过塑造巨噬细胞身份来增强胶原清除作用
Signe Spliid Heltberg,Sander van Putten,Oliver Krigslund et al.
Signe Spliid Heltberg et al.
Tissue remodeling critically depends on fibroblasts and macrophages, but the timely and coordinated induction of phenotypes that promote remodeling-associated extracellular matrix (ECM) and interstitial collagen degradation is poorly unders...
Heparan sulfate buffers the bone resorptive activity of cathepsin K in bone homeostasis [0.03%]
肝素硫酸盐通过缓冲骨代谢稳态中的基质金属蛋白酶K的溶骨活性来维持骨骼平衡
Yin Luo,Xiaoxiao Zhang,Huanmeng Hao et al.
Yin Luo et al.
To understand the physiological significance of the interaction between Cathepsin-K (CtsK) and heparan sulfate (HS) in bone resorption, we manipulated HS-CtsK interaction genetically by mutating three basic residues of CtsK responsible for ...
Basement membrane components define the microenvironment of aggregated fibroblasts in the skin and support their aggregation in vitro [0.03%]
基底膜成分定义了皮肤聚集成纤维细胞的微环境，并支持体外聚集
Hiroki Machida,Jun Yokota,Hironobu Fujiwara
Hiroki Machida
The dermal papilla (DP), a specialized fibroblast aggregate in mammalian skin, plays a pivotal role in hair follicle development and regeneration through epithelial‒mesenchymal interactions. While its aggregated configuration is critical f...
Hypoxia and ascorbic acid: two interconnected microenvironmental factors driving collagen biosynthesis [0.03%]
缺氧和抗坏血酸：两种相互关联的微环境因素，可驱动胶原生物合成
Méline Ricol,Oskar Lipinski,Catherine Moali et al.
Méline Ricol et al.
Inadequate collagen deposition is at the core of various pathologies, including non-healing wounds, fibrotic diseases, and tumour progression. It is therefore paramount to fully understand how central effectors affect collagen synthesis and...
Arylsulfatase I is a novel lysosomal chondroitin endosulfatase regulating endochondral ossification [0.03%]
新型的溶酶体基质凝集素硫酸盐酯酶Arylsulfatase I参与软骨内成骨作用
Rafaela Grecco-Machado,Satomi Nadanaka,Yuko Naito-Matsui et al.
Rafaela Grecco-Machado et al.
During endochondral ossification, chondrocytes undergo maturation and biochemically modify the collagenous extracellular matrix of cartilage. Similar modifications to cartilage proteoglycans (PGs), which are predominantly chondroitin sulfat...
Shuqian Dou,Xin Wang,Yongjing He et al.
Shuqian Dou et al.
Background: While fetal skin achieves scarless healing, the molecular mechanisms underlying this regenerative capacity remain incompletely characterized. This study integrates single-cell RNA sequencing with spatial trans...