Laminin-511-functionalized fibrin gel enables in-gel proliferation of human induced pluripotent stem cells [0.03%]
功能性层粘连蛋白-511的纤维蛋白凝胶能够使人类诱导多能干细胞在凝胶内增殖
Yukimasa Taniguchi,Mamoru Takizawa,Ayaka Hada et al.
Yukimasa Taniguchi et al.
Fibrin is a biocompatible hydrogel that is widely used as a surgical sealant and as a scaffold for in vitro cell culture. Here, we engineered a heterotrimeric chimera between fibrinogen and laminin-511 by connecting the N-terminal self-poly...
Matrix bound nanovesicles: a great promise for TERM in less than a decade of research [0.03%]
矩阵限制型纳米囊泡：不到十年的研究带来的伤口治疗新希望
Dalila Di Francesco,Diego Mantovani,George Hussey et al.
Dalila Di Francesco et al.
Decellularized extracellular matrix materials have been widely studied for tissue engineering and regenerative medicine (TERM) applications, largely because of their intrinsic bioactivity and immunomodulatory potentials. These properties co...
TRANSMEMBRANE AND MULTIPLEXIN COLLAGENS IN DEVELOPMENT AND PATHOBIOLOGY [0.03%]
跨膜及多功能丝氨酸蛋白酶抑制剂型基质金属蛋白酶作用底物(collagens)家族成员在发育和病理生物学中的功能研究
Taina Pihlajaniemi
Taina Pihlajaniemi
At its best, it is exhilarating to make unexpected discoveries when addressing carefully formed scientific hypotheses. This review depicts my scientific journey in the field of extracellular matrix biology, and more specifically in collagen...
Extracellular matrix architecture promotes immunosuppressive microenvironments in pancreatic cancer [0.03%]
细胞外基质结构促进胰腺癌免疫抑制微环境
Mackenzie K Callaway,Brock J Noonan,Kaylee L Schwertfeger et al.
Mackenzie K Callaway et al.
Pancreatic ductal adenocarcinoma (PDA) is an aggressive cancer with poor clinical outcomes, due in part to altered fibrotic environments and striking immune dysfunction. Physical properties within tumors, such as aligned extracellular matri...
Biomechanical and compositional basement membrane defects due to a Col4a1 mutation affect cardiac morphology and function [0.03%]
COL4A1突变导致的基底膜生物力学和组成缺陷影响心脏形态和功能
Erin Boland,Anna Hoyle,Olivia Robertson-Gray et al.
Erin Boland et al.
Collagen IV is a major constituent of basement membranes and mutations in the genes COL4A1 and COL4A2 present clinically as a variable, multi-system disorder called COL4A1 (Gould) syndrome. Evidence from case reports supports a cardiac comp...
Evidence for the major role of PH4⍺EFB in the prolyl 4-hydroxylation of Drosophila collagen IV [0.03%]
PH4αEFB在果蝇IV型胶原脯氨酰4-羟化作用中起主要作用的证据
Yoshihiro Ishikawa,Melissa A Toups,Marwan Elkrewi et al.
Yoshihiro Ishikawa et al.
Collagens are fundamental components of extracellular matrices, requiring precise intracellular post-translational modifications for proper function. Among the modifications, prolyl 4-hydroxylation is critical to stabilise the collagen trip...
Exploring Basement Membrane Dynamics through Cross-Scale Imaging, Manipulation, and Molecular Mapping [0.03%]
通过跨尺度成像、操纵和分子映射探索基底膜动力学
Kohei Omachi,Hironobu Fujiwara
Kohei Omachi
The basement membrane (BM), a specialized extracellular matrix (ECM), provides structural support for epithelial, endothelial, and other parenchymal cells. Once considered a static scaffold, the BM is now recognized as a dynamic and complex...
Laminin γ1 chain is essential for the cardiorespiratory and muscular systems [0.03%]
层粘连蛋白γ1链对心肺和肌肉系统是必不可少的
Kinga I Gawlik,Deniz A Bölükbas,Fatima Daoud et al.
Kinga I Gawlik et al.
Laminins are basement membrane components that regulate a plethora of biological processes. Despite decades of research, the exact roles of laminins in different tissues and in organogenesis remain to be elucidated. Here, we investigated th...
Retraction Notice for "Novel regulatory roles of small leucine-rich proteoglycans in remodeling of the uterine cervix in pregnancy" [Matrix Biology, Volume 105, January 2022, Pages 53-71] [0.03%]
关于《妊娠期间子宫颈重塑中新型小型亮氨酸丰富蛋白聚糖的调控作用》的撤稿声明
Mariano Colon-Caraballo,Nicole Lee,Shanmugasundaram Nallasamy et al.
Mariano Colon-Caraballo et al.
Loss of col4a1 in zebrafish recapitulates the cerebrovascular phenotypes associated with monogenic cerebral small vessel disease [0.03%]
斑马鱼col4a1丢失再现单基因脑小血管病相关的脑血管表型
Daisy Flatman,Richard W Naylor,Siobhan Crilly et al.
Daisy Flatman et al.
Cerebral small vessel disease (cSVD) is a major cause of vascular dementia and stroke. Our understanding of cSVD pathophysiology is incomplete and our ability to treat patients is limited. Pathogenic variants in type IV collagen alpha 1 (CO...